JAZF1

Name	JAZF zinc finger 1
Structure	No pdb structure
Interactors	4 interactors: FAM9B NR2C2 PPARG RXRA
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytosol Transcription Repressor Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process
Diseases	Type II diabetes mellitus
GWAS	A body shape index ( 34021172 ) Alanine aminotransferase levels ( 33339817 33547301 ) Alanine transaminase levels ( 29403010 ) Alcoholic chronic pancreatitis ( 28754779 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Allergic rhinitis ( 30013184 ) Appendicular lean mass ( 33097823 ) Asthma ( 31959851 31619474 30929738 32296059 34103634 31361310 ) Asthma (adult onset) ( 30929738 ) Asthma (childhood onset) ( 30929738 31036433 ) Asthma onset (childhood vs adult) ( 30929738 ) Blond vs. brown/black hair color ( 30531825 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Body mass index and type 2 diabetes (pairwise) ( 33619380 ) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 23128233 ) Eosinophilic esophagitis ( 29904099 ) Fasting glucose ( 34059833 ) FEV1 ( 30804560 ) Free thyroxine concentration ( 24722205 ) Gout ( 22179738 ) Heel bone mineral density ( 28869591 30598549 ) Height ( 28552196 18952825 19343178 20881960 23563607 25282103 ) Hip circumference adjusted for BMI ( 34021172 25673412 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) Lung function (FVC) ( 30804560 ) Lymphocyte count ( 32888494 27863252 ) Lymphocyte percentage of white cells ( 32888494 27863252 ) Medication use (drugs used in diabetes) ( 31015401 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) Moyamoya disease ( 29273593 ) Multiple sclerosis ( 31604244 24076602 ) Neutrophil percentage of white cells ( 32888494 ) Peak expiratory flow ( 30804560 ) Prostate cancer ( 34012061 31562322 18264096 ) Prostate-specific antigen levels ( 28139693 ) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417 ) Rheumatoid arthritis ( 30423114 24390342 ) Systemic lupus erythematosus ( 26606652 28714469 19838195 26502338 ) Systemic lupus erythematosus and Systemic sclerosis ( 23740937 ) Systolic blood pressure ( 30224653 30578418 ) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010 ) Total body bone mineral density ( 29304378 ) Triglyceride levels ( 32203549 ) Type 1 diabetes ( 34127860 ) Type 2 diabetes ( 32499647 30054458 18372903 30297969 29358691 28869590 20581827 22885922 24509480 26961502 31118516 27189021 ) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 25673412 34021172 28448500 28552196 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Youthful appearance (self-reported) ( 32339537 )
Entrez ID	221895
HPRD ID	09373
Ensembl ID	ENSG00000153814
Uniprot IDs	Q86VZ6
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Nuclear Receptor Activity DNA Binding Domain Binding Positive Regulation Of Lipoprotein Transport LBD Domain Binding Peroxisome Proliferator Activated Receptor Signaling Pathway Monocyte Differentiation Intracellular Receptor Signaling Pathway Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Cholesterol Efflux Cellular Response To Low-density Lipoprotein Particle Stimulus Peptide Binding Positive Regulation Of Cholesterol Transport Cellular Response To Lipoprotein Particle Stimulus Transcription Coregulator Binding Regulation Of Cholesterol Efflux MRNA Transcription By RNA Polymerase II Sequence-specific DNA Binding MRNA Transcription Regulation Of Cholesterol Transport Positive Regulation Of Lipid Transport Nuclear Receptor-mediated Signaling Pathway DNA-binding Transcription Factor Activity Double-stranded DNA Binding RNA Polymerase II Transcription Regulator Complex Regulation Of Lipid Transport Positive Regulation Of Lipid Metabolic Process Negative Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Myeloid Leukocyte Differentiation Cell Maturation Hormone-mediated Signaling Pathway Positive Regulation Of Adiponectin Secretion Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Vitamin D Response Element Binding Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Receptor Complex Cellular Developmental Process Developmental Maturation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Prostaglandin Receptor Activity Negative Regulation Of Mitochondrial Fission Positive Regulation Of Protein Transport Myeloid Cell Differentiation Arachidonate Binding Transcription Cis-regulatory Region Binding Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Vitamin D Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process