DSG3

Name	desmoglein 3
Structure
Interactors	4 interactors: CASP3 FURIN JUP PKP3
GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction Desmosome Extracellular Exosome Tight Junction Anchoring Junction
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding Protein Dimerization Activity
	Biological Process	Desmosome Assembly Actin Filament Organization Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Migration Regulation Of Protein Stability Adherens Junction Assembly Cell-cell Adhesion Tight Junction Assembly Positive Regulation Of Bicellular Tight Junction Assembly Negative Regulation Of P38MAPK Cascade Positive Regulation Of Protein Localization To Adherens Junction Positive Regulation Of Protein Localization To Membrane
Pathways	Apoptotic cleavage of cell adhesion proteins Keratinization Formation of the cornified envelope
GWAS	Parkinson's disease (age of onset) ( 19772629 ) Survival in colon cancer ( 25866641 )
Entrez ID	1830
HPRD ID	01355
Ensembl ID	ENSG00000134757
Uniprot IDs	P32926
PDB IDs	5EQX
GO Terms Enriched among Interactors ?	Desmosome Assembly Alpha-catenin Binding Desmosome Organization Epithelial Cell-cell Adhesion Desmosome Cornified Envelope Endopeptidase Activity Protease Binding Gamma-catenin-TCF7L2 Complex Cell Adhesion Molecule Binding Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Regulation Of Cytokine Production Regulation Of Cell Adhesion Phospholipase A2 Activator Activity Cell-cell Junction Assembly Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Regulation Of Multicellular Organismal Process Anterior Neural Tube Closure Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Cellular Response To Staurosporine Protein Processing Protein Localization To Plasma Membrane Cell-cell Junction Organization Adherens Junction Catenin-TCF7L2 Complex Cell-cell Junction Cytoskeletal Protein-membrane Anchor Activity Endothelial Cell-cell Adhesion Viral Translation Viral Life Cycle Negative Regulation Of Receptor Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Luteolysis Glial Cell Apoptotic Process Cellular Response To Indole-3-methanol Protein Localization To Cell Periphery Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Cytokine Precursor Processing Nerve Growth Factor Binding Response To Anesthetic Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cell Junction Assembly Response To Indole-3-methanol Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process