DAD1

Name	defender against cell death 1
Structure
Interactors	3 interactors: ETS2 GLP1R MCL1
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex Membrane Oligosaccharyltransferase Complex A Oligosaccharyltransferase Complex B
	Molecular Function	Enzyme Activator Activity
	Biological Process	Blastocyst Development Protein Glycosylation Protein N-linked Glycosylation Apoptotic Process Protein N-linked Glycosylation Via Asparagine Regulation Of Protein Stability Negative Regulation Of Apoptotic Process
Pathways	Asparagine N-linked glycosylation Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane PD-L1(CD274) glycosylation and translocation to plasma membrane
GWAS	Microalbuminuria ( 26631737 ) Relative hand skill in reading disability ( 24068947 )
Entrez ID	1603
HPRD ID	02589
Ensembl ID	ENSG00000129562
Uniprot IDs	P61803 Q53G02
PDB IDs	6S7O 6S7T 8B6L 8PN9
GO Terms Enriched among Interactors ?	Protein Transmembrane Transport Glucagon-like Peptide 1 Receptor Activity Ectodermal Cell Fate Commitment Glucagon Receptor Activity BH Domain Binding Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Response To Psychosocial Stress BH3 Domain Binding Post-translational Protein Targeting To Membrane, Translocation Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Bcl-2 Family Protein Complex Primitive Streak Formation Cellular Response To Glucagon Stimulus Cell Fate Commitment Involved In Formation Of Primary Germ Layer Activation Of Adenylate Cyclase Activity Nuclear Glucocorticoid Receptor Binding Positive Regulation Of Lyase Activity Positive Regulation Of Adenylate Cyclase Activity Response To Glucagon Mitochondrial Fusion Negative Regulation Of Anoikis Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cyclase Activity Release Of Cytochrome C From Mitochondria Protein Transmembrane Transporter Activity Regulation Of Anoikis Intracellular Protein Transmembrane Transport Positive Regulation Of Blood Pressure Peptide Hormone Binding G Protein-coupled Peptide Receptor Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell Fate Determination Channel Activity Negative Regulation Of Blood Pressure Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway