CYP11A1

Name	cytochrome P450 family 11 subfamily A member 1
Structure
Novel Interactors	1 novel interactors: ETFA
Interactors	5 interactors: CYP11B2 FDX1 SMAD2 SMAD3 SMAD9
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Cholesterol Monooxygenase (side-chain-cleaving) Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Iron-sulfur Protein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Metal Ion Binding
	Biological Process	Alcohol Metabolic Process Lipid Metabolic Process Steroid Biosynthetic Process C21-steroid Hormone Biosynthetic Process Glucocorticoid Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process C21-steroid Hormone Metabolic Process Sterol Metabolic Process Cortisol Metabolic Process Vitamin D Metabolic Process Cellular Response To Peptide Hormone Stimulus Steroid Hormone Biosynthetic Process
Pathways	Pregnenolone biosynthesis Endogenous sterols Defective CYP11A1 causes AICSR
Drugs	Aminoglutethimide Levoketoconazole
Diseases	Congenital adrenal hyperplasia (CAH) 46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
GWAS	Coffee consumption (cups per day) ( 31837886 ) Craniofacial microsomia ( 26853712 ) Diisocyanate-induced asthma ( 25918132 )
Entrez ID	1583
HPRD ID	00326
Ensembl ID	ENSG00000140459
Uniprot IDs	A0A0S2Z3R3 P05108
PDB IDs	3N9Y 3N9Z 3NA0 3NA1
GO Terms Enriched among Interactors ?	Heteromeric SMAD Protein Complex SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction Paraxial Mesoderm Morphogenesis Mesoderm Morphogenesis Pericardium Development Trophoblast Cell Migration Transforming Growth Factor Beta Receptor Signaling Pathway Embryonic Foregut Morphogenesis Nodal Signaling Pathway Co-SMAD Binding Primary MiRNA Processing Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway R-SMAD Binding Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Transcription Regulator Complex Endoderm Development MiRNA Processing Hormone Biosynthetic Process Ureteric Bud Development Negative Regulation Of Ossification Gastrulation Mesonephric Epithelium Development Mesonephric Tubule Development Mesoderm Formation Response To Growth Factor Phosphatase Binding Electron Transfer Activity Formation Of Primary Germ Layer Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Kidney Epithelium Development Response To Transforming Growth Factor Beta Embryonic Skeletal System Morphogenesis Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Steroid Biosynthetic Process Cholesterol Metabolic Process Regulation Of Hormone Levels Steroid 11-beta-monooxygenase Activity Regulation Of Blood Volume By Renal Aldosterone Iron Ion Binding Corticosterone 18-monooxygenase Activity Electron Transport Chain Electron Transfer Flavoprotein Complex