HSCB

Name	HscB mitochondrial iron-sulfur cluster cochaperone
Structure
Novel Interactors	1 novel interactors: FBN1
Interactors	4 interactors: AGTRAP BBS1 BBS2 BBS4
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	ATPase Activator Activity Molecular_function Protein Binding Identical Protein Binding Metal Ion Binding Protein-folding Chaperone Binding
	Biological Process	Iron-sulfur Cluster Assembly [2Fe-2S] Cluster Assembly Protein Complex Oligomerization Primitive Hemopoiesis Primitive Erythrocyte Differentiation
Pathways	Mitochondrial protein import Mitochondrial protein import Mitochondrial iron-sulfur cluster biogenesis Complex I biogenesis Complex III assembly
GWAS	Breast size ( 27182965 ) Diastolic blood pressure ( 27841878 ) Esophageal cancer and gastric cancer ( 20729852 ) Mean platelet volume ( 32888494 ) Myeloproliferative neoplasms ( 33057200 ) Pancreatic cancer ( 25086665 ) Red cell distribution width ( 27863252 ) Systolic blood pressure ( 27841878 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Entrez ID	150274
HPRD ID	16289
Ensembl ID	ENSG00000100209
Uniprot IDs	B0QYH2 Q8IWL3
PDB IDs	3BVO
GO Terms Enriched among Interactors ?	BBSome Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Regulation Of Cilium Beat Frequency Striatum Development Regulation Of Response To Food Brain Morphogenesis Regulation Of Appetite Regulation Of Response To Nutrient Levels Regulation Of Cilium Movement Photoreceptor Cell Maintenance Non-motile Cilium Assembly Regulation Of Microtubule-based Movement Ciliary Membrane Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Hippocampus Development Cerebral Cortex Development Leptin-mediated Signaling Pathway Fat Cell Differentiation Centriolar Satellite Animal Organ Morphogenesis Negative Regulation Of Appetite Adult Behavior Retina Homeostasis Response To Leptin Visual Perception Sensory Perception Of Light Stimulus Ventricular System Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding Melanosome Transport Establishment Of Melanosome Localization Pigment Granule Transport Motile Cilium Melanosome Localization Pigment Granule Localization Regulation Of Microtubule-based Process Cilium Assembly Positive Regulation Of Multicellular Organism Growth Golgi To Plasma Membrane Protein Transport Gene Expression Cilium Organization Dendrite Development Regulation Of Biological Quality Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Establishment Of Protein Localization To Plasma Membrane Protein Localization To Cilium Golgi To Plasma Membrane Transport Maintenance Of Protein Location Regulation Of Multicellular Organism Growth Microtubule Cytoskeleton Organization