ASB11

Name	ankyrin repeat and SOCS box containing 11
Structure
Interactors	7 interactors: BIK CUL5 ELOB ELOC PAICS RNF7 UBC
GO Annotations	Cellular Component	Endoplasmic Reticulum Cytosol Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Protein Ubiquitination Endoplasmic Reticulum Unfolded Protein Response Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Protein K11-linked Ubiquitination
Pathways	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
GWAS	vascular endothelial growth factor D levels ( 25147954 )
Entrez ID	140456
HPRD ID	06450
Ensembl ID	ENSG00000165192
Uniprot IDs	Q8WXH4
PDB IDs	4UUC
GO Terms Enriched among Interactors ?	Cul5-RING Ubiquitin Ligase Complex Target-directed MiRNA Degradation Elongin Complex Negative Regulation Of Focal Adhesion Disassembly Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Erythropoietin-mediated Signaling Pathway Negative Regulation Of Growth Hormone Receptor Signaling Pathway MiRNA Catabolic Process Regulation Of Growth Hormone Receptor Signaling Pathway Reelin-mediated Signaling Pathway Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Macromolecule Catabolic Process Negative Regulation Of MiRNA-mediated Gene Silencing Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cul2-RING Ubiquitin Ligase Complex Layer Formation In Cerebral Cortex Negative Regulation Of Focal Adhesion Assembly Modification-dependent Protein Catabolic Process MiRNA Metabolic Process Growth Hormone Receptor Signaling Pathway Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing CGAS/STING Signaling Pathway Positive Regulation Of Focal Adhesion Assembly Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Cell-matrix Adhesion Protein K11-linked Ubiquitination Protein Modification Process Transcription Initiation At RNA Polymerase II Promoter Regulation Of Neuron Migration Transcription Corepressor Binding Ubiquitin Protein Ligase Binding SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell-substrate Adhesion Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Regulation Of Focal Adhesion Assembly DNA-templated Transcription Initiation Regulation Of Cell-substrate Junction Organization Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity Phosphoribosylaminoimidazole Carboxylase Activity Epithelial To Mesenchymal Transition Proteolysis Mesenchymal Cell Differentiation Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Cell Junction Assembly Symbiont-mediated Suppression Of Host Innate Immune Response