CLIC2

Name	chloride intracellular channel 2
Structure
Novel Interactors	1 novel interactors: EP300
Interactors	4 interactors: NEDD4 NEDD4L TPRN TRAPPC2
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Monoatomic Ion Channel Complex Chloride Channel Complex
	Molecular Function	Glutathione Transferase Activity Glutathione Peroxidase Activity Chloride Channel Activity Protein Binding Oxidoreductase Activity
	Biological Process	Monoatomic Ion Transport Chloride Transport Signal Transduction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Monoatomic Ion Transmembrane Transport Cellular Oxidant Detoxification Chloride Transmembrane Transport
Pathways	Stimuli-sensing channels Ion homeostasis
GWAS	No GWAS studies recorded
Entrez ID	1193
HPRD ID	02139
Ensembl ID	ENSG00000155962
Uniprot IDs	O15247
PDB IDs	2PER 2R4V 2R5G
GO Terms Enriched among Interactors ?	Sodium Channel Inhibitor Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Transmembrane Transporter Binding Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Channel Inhibitor Activity Negative Regulation Of Sodium Ion Transport Receptor Catabolic Process Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transport Neuromuscular Junction Development Receptor Metabolic Process Protein Monoubiquitination Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Neuron Projection Development Receptor Internalization Regulation Of Dendrite Morphogenesis Negative Regulation Of Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transport Cellular Response To UV Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Neuron Projection Development Regulation Of Potassium Ion Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Formation Of Structure Involved In A Symbiotic Process Regulation Of Dendrite Development Negative Regulation Of Monoatomic Ion Transport Cellular Response To Light Stimulus Negative Regulation Of Transmembrane Transport Regulation Of Plasma Membrane Bounded Cell Projection Organization Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Regulation Of Cell Projection Organization Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Regulation Of Nucleocytoplasmic Transport Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Channel Inhibitor Activity Nucleoplasm Positive Regulation Of Intracellular Transport N-terminal Peptidyl-lysine Acetylation