AP1S1

Name	adaptor related protein complex 1 subunit sigma 1
Structure
Novel Interactors	1 novel interactors: TNFRSF9
Interactors	6 interactors: AP1G1 AP1G2 AP1M2 AP2A2 PICK1 RHOU
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Early Endosome Golgi Apparatus Cytosol Clathrin-coated Pit Membrane Membrane Coat AP-1 Adaptor Complex Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Terminal Bouton Intracellular Membrane-bounded Organelle Presynapse
	Molecular Function	Protein Binding Clathrin Adaptor Activity
	Biological Process	Intracellular Protein Transport Receptor-mediated Endocytosis Response To Virus Protein Transport Vesicle-mediated Transport Retrograde Transport, Endosome To Golgi Platelet Dense Granule Organization Basolateral Protein Secretion Melanosome Assembly
Pathways	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
GWAS	Adult body size ( 32376654 ) Serum metabolite concentrations in chronic kidney disease ( 33838163 )
Entrez ID	1174
HPRD ID	04635
Ensembl ID	ENSG00000106367
Uniprot IDs	P61966
PDB IDs	4P6Z
GO Terms Enriched among Interactors ?	Clathrin Adaptor Activity AP-1 Adaptor Complex Membrane Coat Intracellular Protein Transport Basolateral Protein Secretion Clathrin Adaptor Complex Trans-Golgi Network Membrane Protein Transport Vesicle-mediated Transport Intracellular Transport Intracellular Vesicle Golgi To Vacuole Transport Cytoplasmic Vesicle Membrane Establishment Of Protein Localization Golgi Apparatus Golgi Membrane Clathrin-coated Vesicle Membrane Synaptic Vesicle Endocytosis Cellular Localization Establishment Of Localization In Cell Presynaptic Endocytosis Cytoplasmic Vesicle Intracellular Protein Localization Clathrin-coated Pit Endocytic Vesicle Membrane Clathrin-coated Vesicle Endocytosis Vesicle-mediated Transport In Synapse Post-Golgi Vesicle-mediated Transport Synaptic Vesicle Budding From Endosome Protein Localization To Extracellular Region Establishment Of Protein Localization To Extracellular Region Protein Secretion Import Into Cell Membrane Membrane Curvature Sensor Activity Vacuolar Transport Positive Regulation Of Natural Killer Cell Degranulation Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Actin Nucleation Positive Regulation Of Focal Adhesion Disassembly Protein Domain Specific Binding Presynapse Endosome To Melanosome Transport AP-2 Adaptor Complex Golgi To Lysosome Transport Neuronal Ion Channel Clustering Dendritic Spine Maintenance Synapse