GDF11

Name	growth differentiation factor 11
Structure
Novel Interactors	1 novel interactors: RNF41
Interactors	1 interactors: ACVR2B
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Protein-containing Complex
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity
	Biological Process	Skeletal System Development Metanephros Development Ureteric Bud Development Transforming Growth Factor Beta Receptor Signaling Pathway Nervous System Development Mesoderm Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Anterior/posterior Pattern Specification Spinal Cord Anterior/posterior Patterning Neuron Differentiation Pancreas Development Activin Receptor Signaling Pathway Amacrine Cell Differentiation Negative Regulation Of Neuron Differentiation Camera-type Eye Morphogenesis Roof Of Mouth Development Positive Regulation Of SMAD Protein Signal Transduction Type B Pancreatic Cell Maturation Negative Regulation Of Amacrine Cell Differentiation
GWAS	Refractive error ( 32231278 )
Entrez ID	10220
HPRD ID	04895
Ensembl ID	ENSG00000135414
Uniprot IDs	O95390
PDB IDs	5E4G 5JHW 5UHM 6MAC 7MRZ
GO Terms Enriched among Interactors ?	Positive Regulation Of Activin Receptor Signaling Pathway Lymphatic Endothelial Cell Differentiation Venous Blood Vessel Development Activin Receptor Complex Activin Receptor Activity, Type II Activin Receptor Activity Trophoblast Cell Migration Erythropoietin Receptor Binding Interleukin-3 Receptor Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Embryonic Foregut Morphogenesis Activin Binding Negative Regulation Of Adipose Tissue Development Negative Regulation Of Mitophagy Kinase Activator Activity Lymphangiogenesis Retina Vasculature Development In Camera-type Eye Gastrulation With Mouth Forming Second Regulation Of Adipose Tissue Development Endoplasmic Reticulum Tubular Network Pancreas Development Regulation Of Activin Receptor Signaling Pathway Protein Serine/threonine/tyrosine Kinase Activity Endothelial Cell Differentiation Activin Receptor Signaling Pathway Growth Factor Binding Artery Development Insulin Secretion Gastrulation Negative Regulation Of Cold-induced Thermogenesis Organ Growth Negative Regulation Of Ossification Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Blood Vessel Remodeling Negative Regulation Of Macroautophagy Regulation Of Mitophagy Regulation Of Autophagy Of Mitochondrion Regulation Of Multicellular Organismal Development Positive Regulation Of Ossification Mesoderm Development Vasculature Development Receptor Tyrosine Kinase Binding Peptide Hormone Secretion Positive Regulation Of Osteoblast Differentiation Post-embryonic Development Roof Of Mouth Development Regulation Of Bone Mineralization Intracellular Iron Ion Homeostasis Odontogenesis Of Dentin-containing Tooth