KMT2A - Wiki-MPM

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	KAT8	lysine acetyltransferase 8	HATs acetylate histones Formation of WDR5-containing histone-modifying complexes
Novel	LAYN	layilin		Hyaluronic acid
Novel	MCTS1	MCTS1 re-initiation and release factor
Novel	MEN1	menin 1	Formation of the beta-catenin:TCF transactivating complex SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Deactivation of the beta-catenin transactivating complex Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate IQGAPs Post-translational protein phosphorylation Formation of WDR5-containing histone-modifying complexes		Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT) Adrenal carcinoma Malignant islet cell carcinoma Carcinoid
Novel	MTM1	myotubularin 1	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane		Centronuclear myopathy
Novel	OXT	oxytocin/neurophysin I prepropeptide	Vasopressin-like receptors G alpha (q) signalling events
Novel	PAF1	PAF1 component of Paf1/RNA polymerase II complex	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Novel	PAFAH1B2	platelet activating factor acetylhydrolase 1b catalytic subunit 2	Neutrophil degranulation COPI-independent Golgi-to-ER retrograde traffic
Novel	PLAAT4	phospholipase A and acyltransferase 4	Acyl chain remodelling of PE
Novel	PLPP2	phospholipid phosphatase 2	Sphingolipid catabolism
Novel	PLXNB1	plexin B1	G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse RHOD GTPase cycle
Novel	PPIE	peptidylprolyl isomerase E	Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neutrophil degranulation mRNA Splicing - Major Pathway
Novel	PPP1R15A	protein phosphatase 1 regulatory subunit 15A	Downregulation of TGF-beta receptor signaling Response of EIF2AK1 (HRI) to heme deficiency
Novel	PSIP1	PC4 and SRSF1 interacting protein 1	Integration of provirus 2-LTR circle formation Integration of viral DNA into host genomic DNA Autointegration results in viral DNA circles APOBEC3G mediated resistance to HIV-1 infection Vpr-mediated nuclear import of PICs Formation of WDR5-containing histone-modifying complexes
Novel	RBBP5	RB binding protein 5, histone lysine methyltransferase complex subunit	Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Neddylation Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of PD-L1(CD274) transcription Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome
Novel	RBM39	RNA binding motif protein 39	mRNA Splicing - Major Pathway
Novel	RDX	radixin	Recycling pathway of L1 Recycling pathway of L1 Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	1D-myo-inositol 1,4,5-trisphosphate
Novel	RNF2	ring finger protein 2	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Novel	SBF1	SET binding factor 1	Synthesis of PIPs at the ER membrane RAB GEFs exchange GTP for GDP on RABs
Novel	SET	SET nuclear proto-oncogene	Condensation of Prophase Chromosomes HuR (ELAVL1) binds and stabilizes mRNA

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