KMT2A and RBBP5

Number of citations of the paper that reports this interaction (PubMedID 15199122)
69

Data Source:
BioGRID (proximity labelling technology)
HPRD (in vitro, in vivo)

		KMT2A	RBBP5
Description		lysine methyltransferase 2A	RB binding protein 5, histone lysine methyltransferase complex subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Histone Methyltransferase Complex MLL1/2 Complex MLL1 Complex	Nucleus Nucleoplasm Nucleolus Histone Methyltransferase Complex MLL1/2 Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex
	Molecular Function	DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Chromatin Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone H3K4 Methyltransferase Activity Identical Protein Binding Protein Homodimerization Activity Unmethylated CpG Binding Metal Ion Binding Protein-cysteine Methyltransferase Activity Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity	Transcription Cis-regulatory Region Binding Protein Binding Histone Binding
	Biological Process	Immune System Process Chromatin Organization Regulation Of DNA-templated Transcription Apoptotic Process Visual Learning Response To Light Stimulus Post-embryonic Development Anterior/posterior Pattern Specification Regulation Of Gene Expression Positive Regulation Of Gene Expression Methylation Circadian Regulation Of Gene Expression Embryonic Hemopoiesis Exploration Behavior Response To Potassium Ion Protein Modification Process Epigenetic Regulation Of Gene Expression T-helper 2 Cell Differentiation Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Regulation Of Short-term Neuronal Synaptic Plasticity Rhythmic Process Spleen Development Homeostasis Of Number Of Cells Within A Tissue Cognition Membrane Depolarization Definitive Hemopoiesis Protein-containing Complex Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation	Chromatin Organization DNA Damage Response Response To Estrogen Transcription Initiation-coupled Chromatin Remodeling
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis Formation of WDR5-containing histone-modifying complexes Regulation of PD-L1(CD274) transcription Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Neddylation Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of PD-L1(CD274) transcription Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Metabolic syndrome ( 31589552) Refractive error ( 32231278) Triglyceride levels ( 32203549)	Basophil percentage of granulocytes ( 27863252) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Mean platelet volume ( 24026423 32888494) Meat-related diet ( 32066663) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549)
Interacting Genes		46 interacting genes: ASH2L AVP BMI1 CBX4 CKMT1A CREBBP CTNNB1 DCTN1 EXOSC5 FASLG H2AC4 H2BC3 H3-3A H3C1 H3C14 HCFC1 HCFC2 IL10RA INPPL1 INS KAT8 LAYN MCTS1 MEN1 MTM1 OXT PAF1 PAFAH1B2 PLAAT4 PLPP2 PLXNB1 PPIE PPP1R15A PSIP1 RBBP5 RBM39 RDX RNF2 SBF1 SET SVIL TAF9 TASP1 TGFB2 VWA5A WDR5	13 interacting genes: CHD8 CTBP1 CTNNB1 H3-4 H3C14 KMT2A KMT2B MEN1 PTEN RB1 RBM39 UBE2I WDR5
Entrez ID		4297	5929
HPRD ID		01162	02826
Ensembl ID		ENSG00000118058	ENSG00000117222
Uniprot IDs		A0AA34QVI8 E9PR05 Q03164	B4DLF8 Q15291
PDB IDs		2AGH 2J2S 2JYI 2KKF 2KU7 2KYU 2LXS 2LXT 2MSR 2MTN 2W5Y 2W5Z 3EG6 3EMH 3LQH 3LQI 3LQJ 3P4F 3U85 3U88 4ESG 4GQ6 4NW3 5F5E 5F6L 5SVH 6EMQ 6KIU 6KIV 6KIX 6KIZ 6PWV 6PWW 6U9K 6U9M 6U9N 6U9R 6W5I 6W5M 6W5N 7MBM 7MBN 7RZD 7RZJ 7S79 7S7D 7S8A 7S8E 7S8F 7U5V 7W67 7W6A 7W6I 7W6J 7ZEY 7ZEZ	3P4F 4X8N 4X8P 5F6K 5F6L 6KIU 6KIV 6KIW 6KIX 6KIZ 6KM7 6PWV 6PWW 6PWX 6W5I 6W5M 6W5N 7BRE 7MBM 7MBN 7UD5 7W67 7W6A 7W6I 7W6J 7W6L 8DU4
Enriched GO Terms of Interacting Partners?		MLL1 Complex Chromatin Remodeling MLL1/2 Complex Chromatin Organization Histone Methyltransferase Complex Set1C/COMPASS Complex Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression, Epigenetic Negative Regulation Of Biosynthetic Process Histone Acetyltransferase Complex NSL Complex Structural Constituent Of Chromatin Negative Regulation Of DNA-templated Transcription Nucleoplasm MLL3/4 Complex Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Neurohypophyseal Hormone Activity DNA-binding Transcription Factor Binding Negative Regulation Of RNA Metabolic Process Transcription Coactivator Activity Nucleosome Assembly Protein-DNA Complex Assembly PRC1 Complex Nucleosome Euchromatin RING-like Zinc Finger Domain Binding Nucleosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Heterodimerization Activity Maternal Aggressive Behavior Positive Regulation Of Macromolecule Biosynthetic Process PcG Protein Complex Positive Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Histone Acetyltransferase Activity Positive Regulation Of Metabolic Process Cell Development Regulation Of Cell Cycle	MLL1/2 Complex Nucleoplasm Histone Methyltransferase Complex Chromatin Remodeling MLL1 Complex Chromatin Organization Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Histone H3K4 Methyltransferase Activity Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coregulator Binding Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression, Epigenetic Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Histone H3K4 Monomethyltransferase Activity T-helper 2 Cell Differentiation Unmethylated CpG Binding Histone H3K4 Trimethyltransferase Activity Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Synaptic Vesicle Clustering Presynaptic Active Zone Cytoplasmic Component Epigenetic Regulation Of Gene Expression Prepulse Inhibition Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle Negative Regulation Of Protein Phosphorylation PML Body Positive Regulation Of Macromolecule Metabolic Process
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