KMT2A and PSIP1

Number of citations of the paper that reports this interaction (PubMedID 25082813)
0

Data Source:
BioGRID (pull down)

		KMT2A	PSIP1
Description		lysine methyltransferase 2A	PC4 and SRSF1 interacting protein 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Histone Methyltransferase Complex MLL1/2 Complex MLL1 Complex	Euchromatin Heterochromatin Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Periphery
	Molecular Function	DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Chromatin Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone H3K4 Methyltransferase Activity Identical Protein Binding Protein Homodimerization Activity Unmethylated CpG Binding Metal Ion Binding Protein-cysteine Methyltransferase Activity Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity	DNA Binding Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Binding Supercoiled DNA Binding DNA-binding Transcription Factor Binding
	Biological Process	Immune System Process Chromatin Organization Regulation Of DNA-templated Transcription Apoptotic Process Visual Learning Response To Light Stimulus Post-embryonic Development Anterior/posterior Pattern Specification Regulation Of Gene Expression Positive Regulation Of Gene Expression Methylation Circadian Regulation Of Gene Expression Embryonic Hemopoiesis Exploration Behavior Response To Potassium Ion Protein Modification Process Epigenetic Regulation Of Gene Expression T-helper 2 Cell Differentiation Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Regulation Of Short-term Neuronal Synaptic Plasticity Rhythmic Process Spleen Development Homeostasis Of Number Of Cells Within A Tissue Cognition Membrane Depolarization Definitive Hemopoiesis Protein-containing Complex Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation	MRNA 5'-splice Site Recognition Chromatin Remodeling Response To Oxidative Stress Response To Heat Positive Regulation Of Transcription By RNA Polymerase II
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis Formation of WDR5-containing histone-modifying complexes Regulation of PD-L1(CD274) transcription Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	Integration of provirus 2-LTR circle formation Integration of viral DNA into host genomic DNA Autointegration results in viral DNA circles APOBEC3G mediated resistance to HIV-1 infection Vpr-mediated nuclear import of PICs Formation of WDR5-containing histone-modifying complexes
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Metabolic syndrome ( 31589552) Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		46 interacting genes: ASH2L AVP BMI1 CBX4 CKMT1A CREBBP CTNNB1 DCTN1 EXOSC5 FASLG H2AC4 H2BC3 H3-3A H3C1 H3C14 HCFC1 HCFC2 IL10RA INPPL1 INS KAT8 LAYN MCTS1 MEN1 MTM1 OXT PAF1 PAFAH1B2 PLAAT4 PLPP2 PLXNB1 PPIE PPP1R15A PSIP1 RBBP5 RBM39 RDX RNF2 SBF1 SET SVIL TAF9 TASP1 TGFB2 VWA5A WDR5	18 interacting genes: CASP3 CASP7 CDC42 CEBPA CSNK2A1 HCFC1 HMGA1 HMGA2 KMT2A MAPK6 MTDH OGT SP1 SRSF1 SUB1 SUMO1 UBC USP7
Entrez ID		4297	11168
HPRD ID		01162	04688
Ensembl ID		ENSG00000118058	ENSG00000164985
Uniprot IDs		A0AA34QVI8 E9PR05 Q03164	O75475
PDB IDs		2AGH 2J2S 2JYI 2KKF 2KU7 2KYU 2LXS 2LXT 2MSR 2MTN 2W5Y 2W5Z 3EG6 3EMH 3LQH 3LQI 3LQJ 3P4F 3U85 3U88 4ESG 4GQ6 4NW3 5F5E 5F6L 5SVH 6EMQ 6KIU 6KIV 6KIX 6KIZ 6PWV 6PWW 6U9K 6U9M 6U9N 6U9R 6W5I 6W5M 6W5N 7MBM 7MBN 7RZD 7RZJ 7S79 7S7D 7S8A 7S8E 7S8F 7U5V 7W67 7W6A 7W6I 7W6J 7ZEY 7ZEZ	1Z9E 2B4J 2M16 2MSR 2MTN 2N3A 3F9K 3HPG 3HPH 3U88 3ZEH 4FU6 5N88 5OYM 5YI9 6EMO 6EMP 6EMQ 6EMR 6S01 6TRJ 6TVM 6ZV0 7OUF 7OUG 7OUH 7PEL 7Z1Z 8CBN 8CBQ 8PC5 8PC6 8PEO 8PEP
Enriched GO Terms of Interacting Partners?		MLL1 Complex Chromatin Remodeling MLL1/2 Complex Chromatin Organization Histone Methyltransferase Complex Set1C/COMPASS Complex Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression, Epigenetic Negative Regulation Of Biosynthetic Process Histone Acetyltransferase Complex NSL Complex Structural Constituent Of Chromatin Negative Regulation Of DNA-templated Transcription Nucleoplasm MLL3/4 Complex Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Neurohypophyseal Hormone Activity DNA-binding Transcription Factor Binding Negative Regulation Of RNA Metabolic Process Transcription Coactivator Activity Nucleosome Assembly Protein-DNA Complex Assembly PRC1 Complex Nucleosome Euchromatin RING-like Zinc Finger Domain Binding Nucleosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Heterodimerization Activity Maternal Aggressive Behavior Positive Regulation Of Macromolecule Biosynthetic Process PcG Protein Complex Positive Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Histone Acetyltransferase Activity Positive Regulation Of Metabolic Process Cell Development Regulation Of Cell Cycle	Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Minor Groove Of Adenine-thymine-rich DNA Binding Positive Regulation Of Metabolic Process Rhythmic Process Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Execution Phase Of Apoptosis Negative Regulation Of Biosynthetic Process Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of RNA Metabolic Process Cellular Response To Staurosporine Senescence-associated Heterochromatin Focus Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Pyroptotic Inflammatory Response Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis 5'-deoxyribose-5-phosphate Lyase Activity Oncogene-induced Cell Senescence Negative Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Regulation Of Protein Stability Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Catabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Regulation Of Proteolysis Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process
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