Diabetes - Wiki-Pi

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PTPN11 and PTK2B	protein tyrosine phosphatase, non-receptor type 11	protein tyrosine kinase 2 beta	Signaling by FGFR in disease Netrin mediated repulsion signals Signaling by EGFRvIII in Cancer Interferon gamma signaling Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Prolactin receptor signaling SHC-mediated signalling PI3K Cascade TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation Spry regulation of FGF signaling Constitutive PI3K/AKT Signaling in Cancer Platelet sensitization by LDL Signaling by VEGF Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction Interleukin-2 signaling PI3K/AKT Signaling in Cancer Frs2-mediated activation Adaptive Immune System Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation PI3K events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Netrin-1 signaling RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade Interferon Signaling CTLA4 inhibitory signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Tie2 Signaling PECAM1 interactions Signaling by FGFR ARMS-mediated activation Nuclear signaling by ERBB4 Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PD-1 signaling PI3K Cascade Signaling by the B Cell Receptor (BCR) Signaling by GPCR FCERI mediated MAPK activation Signaling by SCF-KIT SHC1 events in ERBB2 signaling DAP12 signaling PI-3K cascade Toll Like Receptor 9 (TLR9) Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions Regulation of IFNA signaling GAB1 signalosome GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Signal regulatory protein (SIRP) family interactions Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Platelet homeostasis Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Costimulation by the CD28 family ERK activation PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Interferon alpha/beta signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell surface interactions at the vascular wall ERK2 activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade ERK2 activation Regulation of IFNG signaling	Signaling by Interleukins Signaling by VEGF Cytokine Signaling in Immune system Interleukin-2 signaling Signal regulatory protein (SIRP) family interactions VEGFA-VEGFR2 Pathway	Dodecane-Trimethylamine	Leflunomide Genistein 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide
PTPN11 and MS4A2	protein tyrosine phosphatase, non-receptor type 11	membrane-spanning 4-domains, subfamily A, member 2	Signaling by FGFR in disease Netrin mediated repulsion signals Signaling by EGFRvIII in Cancer Interferon gamma signaling Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Prolactin receptor signaling SHC-mediated signalling PI3K Cascade TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation Spry regulation of FGF signaling Constitutive PI3K/AKT Signaling in Cancer Platelet sensitization by LDL Signaling by VEGF Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction Interleukin-2 signaling PI3K/AKT Signaling in Cancer Frs2-mediated activation Adaptive Immune System Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation PI3K events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Netrin-1 signaling RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade Interferon Signaling CTLA4 inhibitory signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Tie2 Signaling PECAM1 interactions Signaling by FGFR ARMS-mediated activation Nuclear signaling by ERBB4 Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PD-1 signaling PI3K Cascade Signaling by the B Cell Receptor (BCR) Signaling by GPCR FCERI mediated MAPK activation Signaling by SCF-KIT SHC1 events in ERBB2 signaling DAP12 signaling PI-3K cascade Toll Like Receptor 9 (TLR9) Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions Regulation of IFNA signaling GAB1 signalosome GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Signal regulatory protein (SIRP) family interactions Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Platelet homeostasis Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Costimulation by the CD28 family ERK activation PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Interferon alpha/beta signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell surface interactions at the vascular wall ERK2 activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade ERK2 activation Regulation of IFNG signaling	FCERI mediated NF-kB activation Fc epsilon receptor (FCERI) signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization Role of LAT2/NTAL/LAB on calcium mobilization Innate Immune System	Dodecane-Trimethylamine
PTPN11 and TRIM32	protein tyrosine phosphatase, non-receptor type 11	tripartite motif containing 32	Signaling by FGFR in disease Netrin mediated repulsion signals Signaling by EGFRvIII in Cancer Interferon gamma signaling Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Prolactin receptor signaling SHC-mediated signalling PI3K Cascade TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation Spry regulation of FGF signaling Constitutive PI3K/AKT Signaling in Cancer Platelet sensitization by LDL Signaling by VEGF Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction Interleukin-2 signaling PI3K/AKT Signaling in Cancer Frs2-mediated activation Adaptive Immune System Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation PI3K events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Netrin-1 signaling RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade Interferon Signaling CTLA4 inhibitory signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Tie2 Signaling PECAM1 interactions Signaling by FGFR ARMS-mediated activation Nuclear signaling by ERBB4 Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PD-1 signaling PI3K Cascade Signaling by the B Cell Receptor (BCR) Signaling by GPCR FCERI mediated MAPK activation Signaling by SCF-KIT SHC1 events in ERBB2 signaling DAP12 signaling PI-3K cascade Toll Like Receptor 9 (TLR9) Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions Regulation of IFNA signaling GAB1 signalosome GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Signal regulatory protein (SIRP) family interactions Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Platelet homeostasis Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Costimulation by the CD28 family ERK activation PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Interferon alpha/beta signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell surface interactions at the vascular wall ERK2 activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade ERK2 activation Regulation of IFNG signaling	Antigen processing: Ubiquitination & Proteasome degradation Regulation of innate immune responses to cytosolic DNA Cytosolic sensors of pathogen-associated DNA Class I MHC mediated antigen processing & presentation Innate Immune System Adaptive Immune System	Dodecane-Trimethylamine
PTPN11 and GHR	protein tyrosine phosphatase, non-receptor type 11	growth hormone receptor	Signaling by FGFR in disease Netrin mediated repulsion signals Signaling by EGFRvIII in Cancer Interferon gamma signaling Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Prolactin receptor signaling SHC-mediated signalling PI3K Cascade TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation Spry regulation of FGF signaling Constitutive PI3K/AKT Signaling in Cancer Platelet sensitization by LDL Signaling by VEGF Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction Interleukin-2 signaling PI3K/AKT Signaling in Cancer Frs2-mediated activation Adaptive Immune System Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation PI3K events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Netrin-1 signaling RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade Interferon Signaling CTLA4 inhibitory signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Tie2 Signaling PECAM1 interactions Signaling by FGFR ARMS-mediated activation Nuclear signaling by ERBB4 Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PD-1 signaling PI3K Cascade Signaling by the B Cell Receptor (BCR) Signaling by GPCR FCERI mediated MAPK activation Signaling by SCF-KIT SHC1 events in ERBB2 signaling DAP12 signaling PI-3K cascade Toll Like Receptor 9 (TLR9) Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions Regulation of IFNA signaling GAB1 signalosome GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Signal regulatory protein (SIRP) family interactions Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Platelet homeostasis Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Costimulation by the CD28 family ERK activation PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Interferon alpha/beta signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell surface interactions at the vascular wall ERK2 activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade ERK2 activation Regulation of IFNG signaling	Nuclear signaling by ERBB4 Cytokine Signaling in Immune system Signaling by ERBB4 Prolactin receptor signaling Growth hormone receptor signaling	Dodecane-Trimethylamine	Somatropin recombinant Pegvisomant
PTPN11 and PRLR	protein tyrosine phosphatase, non-receptor type 11	prolactin receptor	Signaling by FGFR in disease Netrin mediated repulsion signals Signaling by EGFRvIII in Cancer Interferon gamma signaling Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Prolactin receptor signaling SHC-mediated signalling PI3K Cascade TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation Spry regulation of FGF signaling Constitutive PI3K/AKT Signaling in Cancer Platelet sensitization by LDL Signaling by VEGF Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction Interleukin-2 signaling PI3K/AKT Signaling in Cancer Frs2-mediated activation Adaptive Immune System Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation PI3K events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Netrin-1 signaling RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade Interferon Signaling CTLA4 inhibitory signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Tie2 Signaling PECAM1 interactions Signaling by FGFR ARMS-mediated activation Nuclear signaling by ERBB4 Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PD-1 signaling PI3K Cascade Signaling by the B Cell Receptor (BCR) Signaling by GPCR FCERI mediated MAPK activation Signaling by SCF-KIT SHC1 events in ERBB2 signaling DAP12 signaling PI-3K cascade Toll Like Receptor 9 (TLR9) Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions Regulation of IFNA signaling GAB1 signalosome GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Signal regulatory protein (SIRP) family interactions Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Platelet homeostasis Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Costimulation by the CD28 family ERK activation PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Interferon alpha/beta signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell surface interactions at the vascular wall ERK2 activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade ERK2 activation Regulation of IFNG signaling	Nuclear signaling by ERBB4 Cytokine Signaling in Immune system Signaling by ERBB4 Prolactin receptor signaling Growth hormone receptor signaling	Dodecane-Trimethylamine	Somatropin recombinant Fluoxymesterone
PTPN11 and ACTN4	protein tyrosine phosphatase, non-receptor type 11	actinin, alpha 4	Signaling by FGFR in disease Netrin mediated repulsion signals Signaling by EGFRvIII in Cancer Interferon gamma signaling Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Prolactin receptor signaling SHC-mediated signalling PI3K Cascade TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation Spry regulation of FGF signaling Constitutive PI3K/AKT Signaling in Cancer Platelet sensitization by LDL Signaling by VEGF Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction Interleukin-2 signaling PI3K/AKT Signaling in Cancer Frs2-mediated activation Adaptive Immune System Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation PI3K events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Netrin-1 signaling RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade Interferon Signaling CTLA4 inhibitory signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Tie2 Signaling PECAM1 interactions Signaling by FGFR ARMS-mediated activation Nuclear signaling by ERBB4 Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PD-1 signaling PI3K Cascade Signaling by the B Cell Receptor (BCR) Signaling by GPCR FCERI mediated MAPK activation Signaling by SCF-KIT SHC1 events in ERBB2 signaling DAP12 signaling PI-3K cascade Toll Like Receptor 9 (TLR9) Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions Regulation of IFNA signaling GAB1 signalosome GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Signal regulatory protein (SIRP) family interactions Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Platelet homeostasis Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Costimulation by the CD28 family ERK activation PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Interferon alpha/beta signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell surface interactions at the vascular wall ERK2 activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade ERK2 activation Regulation of IFNG signaling	Response to elevated platelet cytosolic Ca2+ Nephrin interactions Platelet degranulation Platelet activation, signaling and aggregation	Dodecane-Trimethylamine
PTPN11 and CAT	protein tyrosine phosphatase, non-receptor type 11	catalase	Signaling by FGFR in disease Netrin mediated repulsion signals Signaling by EGFRvIII in Cancer Interferon gamma signaling Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Prolactin receptor signaling SHC-mediated signalling PI3K Cascade TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation Spry regulation of FGF signaling Constitutive PI3K/AKT Signaling in Cancer Platelet sensitization by LDL Signaling by VEGF Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction Interleukin-2 signaling PI3K/AKT Signaling in Cancer Frs2-mediated activation Adaptive Immune System Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation PI3K events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Netrin-1 signaling RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade Interferon Signaling CTLA4 inhibitory signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Tie2 Signaling PECAM1 interactions Signaling by FGFR ARMS-mediated activation Nuclear signaling by ERBB4 Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PD-1 signaling PI3K Cascade Signaling by the B Cell Receptor (BCR) Signaling by GPCR FCERI mediated MAPK activation Signaling by SCF-KIT SHC1 events in ERBB2 signaling DAP12 signaling PI-3K cascade Toll Like Receptor 9 (TLR9) Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions Regulation of IFNA signaling GAB1 signalosome GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Signal regulatory protein (SIRP) family interactions Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Platelet homeostasis Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Costimulation by the CD28 family ERK activation PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Interferon alpha/beta signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell surface interactions at the vascular wall ERK2 activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade ERK2 activation Regulation of IFNG signaling	Purine catabolism Purine metabolism Detoxification of Reactive Oxygen Species Metabolism of nucleotides	Dodecane-Trimethylamine	Fomepizole Heme
PTPN11 and EPHA2	protein tyrosine phosphatase, non-receptor type 11	EPH receptor A2	Signaling by FGFR in disease Netrin mediated repulsion signals Signaling by EGFRvIII in Cancer Interferon gamma signaling Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Prolactin receptor signaling SHC-mediated signalling PI3K Cascade TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation Spry regulation of FGF signaling Constitutive PI3K/AKT Signaling in Cancer Platelet sensitization by LDL Signaling by VEGF Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction Interleukin-2 signaling PI3K/AKT Signaling in Cancer Frs2-mediated activation Adaptive Immune System Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation PI3K events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Netrin-1 signaling RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade Interferon Signaling CTLA4 inhibitory signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Tie2 Signaling PECAM1 interactions Signaling by FGFR ARMS-mediated activation Nuclear signaling by ERBB4 Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PD-1 signaling PI3K Cascade Signaling by the B Cell Receptor (BCR) Signaling by GPCR FCERI mediated MAPK activation Signaling by SCF-KIT SHC1 events in ERBB2 signaling DAP12 signaling PI-3K cascade Toll Like Receptor 9 (TLR9) Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions Regulation of IFNA signaling GAB1 signalosome GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Signal regulatory protein (SIRP) family interactions Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Platelet homeostasis Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Costimulation by the CD28 family ERK activation PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Interferon alpha/beta signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell surface interactions at the vascular wall ERK2 activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade ERK2 activation Regulation of IFNG signaling	EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	Dodecane-Trimethylamine	Dasatinib Phosphoaminophosphonic Acid-Adenylate Ester Regorafenib
PTPN11 and FLT1	protein tyrosine phosphatase, non-receptor type 11	fms-related tyrosine kinase 1	Signaling by FGFR in disease Netrin mediated repulsion signals Signaling by EGFRvIII in Cancer Interferon gamma signaling Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Prolactin receptor signaling SHC-mediated signalling PI3K Cascade TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation Spry regulation of FGF signaling Constitutive PI3K/AKT Signaling in Cancer Platelet sensitization by LDL Signaling by VEGF Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction Interleukin-2 signaling PI3K/AKT Signaling in Cancer Frs2-mediated activation Adaptive Immune System Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation PI3K events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Netrin-1 signaling RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade Interferon Signaling CTLA4 inhibitory signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Tie2 Signaling PECAM1 interactions Signaling by FGFR ARMS-mediated activation Nuclear signaling by ERBB4 Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PD-1 signaling PI3K Cascade Signaling by the B Cell Receptor (BCR) Signaling by GPCR FCERI mediated MAPK activation Signaling by SCF-KIT SHC1 events in ERBB2 signaling DAP12 signaling PI-3K cascade Toll Like Receptor 9 (TLR9) Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions Regulation of IFNA signaling GAB1 signalosome GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Signal regulatory protein (SIRP) family interactions Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Platelet homeostasis Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Costimulation by the CD28 family ERK activation PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Interferon alpha/beta signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell surface interactions at the vascular wall ERK2 activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade ERK2 activation Regulation of IFNG signaling	VEGF binds to VEGFR leading to receptor dimerization VEGF ligand-receptor interactions Signaling by VEGF Neurophilin interactions with VEGF and VEGFR	Dodecane-Trimethylamine	Sorafenib Sunitinib Pazopanib Axitinib N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide Regorafenib
PTPN11 and IFNAR1	protein tyrosine phosphatase, non-receptor type 11	interferon (alpha, beta and omega) receptor 1	Signaling by FGFR in disease Netrin mediated repulsion signals Signaling by EGFRvIII in Cancer Interferon gamma signaling Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Prolactin receptor signaling SHC-mediated signalling PI3K Cascade TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation Spry regulation of FGF signaling Constitutive PI3K/AKT Signaling in Cancer Platelet sensitization by LDL Signaling by VEGF Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction Interleukin-2 signaling PI3K/AKT Signaling in Cancer Frs2-mediated activation Adaptive Immune System Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation PI3K events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Netrin-1 signaling RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade Interferon Signaling CTLA4 inhibitory signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Tie2 Signaling PECAM1 interactions Signaling by FGFR ARMS-mediated activation Nuclear signaling by ERBB4 Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PD-1 signaling PI3K Cascade Signaling by the B Cell Receptor (BCR) Signaling by GPCR FCERI mediated MAPK activation Signaling by SCF-KIT SHC1 events in ERBB2 signaling DAP12 signaling PI-3K cascade Toll Like Receptor 9 (TLR9) Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions Regulation of IFNA signaling GAB1 signalosome GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Signal regulatory protein (SIRP) family interactions Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Platelet homeostasis Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Costimulation by the CD28 family ERK activation PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Interferon alpha/beta signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell surface interactions at the vascular wall ERK2 activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade ERK2 activation Regulation of IFNG signaling	Regulation of IFNA signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling	Dodecane-Trimethylamine	Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon Alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon Alfa-2b, Recombinant
PTPN11 and IFNGR1	protein tyrosine phosphatase, non-receptor type 11	interferon gamma receptor 1	Signaling by FGFR in disease Netrin mediated repulsion signals Signaling by EGFRvIII in Cancer Interferon gamma signaling Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Prolactin receptor signaling SHC-mediated signalling PI3K Cascade TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation Spry regulation of FGF signaling Constitutive PI3K/AKT Signaling in Cancer Platelet sensitization by LDL Signaling by VEGF Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction Interleukin-2 signaling PI3K/AKT Signaling in Cancer Frs2-mediated activation Adaptive Immune System Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation PI3K events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Netrin-1 signaling RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade Interferon Signaling CTLA4 inhibitory signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Tie2 Signaling PECAM1 interactions Signaling by FGFR ARMS-mediated activation Nuclear signaling by ERBB4 Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PD-1 signaling PI3K Cascade Signaling by the B Cell Receptor (BCR) Signaling by GPCR FCERI mediated MAPK activation Signaling by SCF-KIT SHC1 events in ERBB2 signaling DAP12 signaling PI-3K cascade Toll Like Receptor 9 (TLR9) Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions Regulation of IFNA signaling GAB1 signalosome GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Signal regulatory protein (SIRP) family interactions Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Platelet homeostasis Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Costimulation by the CD28 family ERK activation PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Interferon alpha/beta signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell surface interactions at the vascular wall ERK2 activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade ERK2 activation Regulation of IFNG signaling	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Regulation of IFNG signaling	Dodecane-Trimethylamine	Interferon gamma-1b
PTPN11 and IGF1R	protein tyrosine phosphatase, non-receptor type 11	insulin-like growth factor 1 receptor	Signaling by FGFR in disease Netrin mediated repulsion signals Signaling by EGFRvIII in Cancer Interferon gamma signaling Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Prolactin receptor signaling SHC-mediated signalling PI3K Cascade TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation Spry regulation of FGF signaling Constitutive PI3K/AKT Signaling in Cancer Platelet sensitization by LDL Signaling by VEGF Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction Interleukin-2 signaling PI3K/AKT Signaling in Cancer Frs2-mediated activation Adaptive Immune System Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation PI3K events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Netrin-1 signaling RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade Interferon Signaling CTLA4 inhibitory signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Tie2 Signaling PECAM1 interactions Signaling by FGFR ARMS-mediated activation Nuclear signaling by ERBB4 Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PD-1 signaling PI3K Cascade Signaling by the B Cell Receptor (BCR) Signaling by GPCR FCERI mediated MAPK activation Signaling by SCF-KIT SHC1 events in ERBB2 signaling DAP12 signaling PI-3K cascade Toll Like Receptor 9 (TLR9) Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions Regulation of IFNA signaling GAB1 signalosome GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Signal regulatory protein (SIRP) family interactions Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Platelet homeostasis Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Costimulation by the CD28 family ERK activation PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Interferon alpha/beta signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell surface interactions at the vascular wall ERK2 activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade ERK2 activation Regulation of IFNG signaling	IRS-related events triggered by IGF1R Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) SHC-related events triggered by IGF1R IGF1R signaling cascade	Dodecane-Trimethylamine	Insulin Regular Insulin Lispro Insulin Glargine Insulin, porcine Mecasermin Alpha-D-Mannose Phosphoaminophosphonic Acid-Adenylate Ester (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione 3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE
MAPK1 and ITGB6	mitogen-activated protein kinase 1	integrin, beta 6	phospho-PLA2 pathway Ca-dependent events Signaling by FGFR in disease Cellular Senescence ERKs are inactivated CREB phosphorylation through the activation of Ras Signaling by EGFRvIII in Cancer Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Fcgamma receptor (FCGR) dependent phagocytosis SHC-mediated signalling Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Regulation of actin dynamics for phagocytic cup formation TRIF-mediated TLR3/TLR4 signaling Senescence-Associated Secretory Phenotype (SASP) Signaling by VEGF Signalling to RAS Downstream signal transduction Toll Like Receptor 3 (TLR3) Cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Frs2-mediated activation Transmission across Chemical Synapses Axon guidance IRS-mediated signalling L1CAM interactions Oncogene Induced Senescence VEGFA-VEGFR2 Pathway Activated TLR4 signalling VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling RSK activation Activation of NMDA receptor upon glutamate binding and postsynaptic events TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane NCAM signaling for neurite out-growth Signalling to p38 via RIT and RIN RAF/MAP kinase cascade Innate Immune System Signaling by Insulin receptor ERKs are inactivated Signal transduction by L1 Insulin receptor signalling cascade PLC beta mediated events IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer SHC-related events G-protein mediated events Signaling by FGFR Thrombin signalling through proteinase activated receptors (PARs) ARMS-mediated activation Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signal attenuation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) ERK/MAPK targets MAPK targets/ Nuclear events mediated by MAP kinases Signaling by GPCR Mitotic Prophase Golgi Cisternae Pericentriolar Stack Reorganization FCERI mediated MAPK activation Signaling by SCF-KIT SHC1 events in ERBB2 signaling DAP12 signaling Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions Opioid Signalling SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Signaling by Leptin Growth hormone receptor signaling Signalling to ERKs Prolonged ERK activation events ERK activation Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Recycling pathway of L1 M Phase Toll Like Receptor TLR6:TLR2 Cascade IRS-related events triggered by IGF1R Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Advanced glycosylation endproduct receptor signaling Post NMDA receptor activation events Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system Cellular response to heat stress Regulation of HSF1-mediated heat shock response NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Signaling by Overexpressed Wild-Type EGFR in Cancer Cell Cycle, Mitotic ERK2 activation SHC1 events in EGFR signaling FRS2-mediated cascade IRS-mediated signalling Oxidative Stress Induced Senescence ERK2 activation Nuclear Events (kinase and transcription factor activation)	Molecules associated with elastic fibres Elastic fibre formation ECM proteoglycans Integrin cell surface interactions	Isoproterenol Arsenic trioxide Olomoucine Phosphonothreonine Purvalanol SB220025 N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE (S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE (3R,5Z,8S,9S,11E)-8,9,16-TRIHYDROXY-14-METHOXY-3-METHYL-3,4,9,10-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,7(8H)-DIONE 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE (1aR,8S,13S,14S,15aR)-5,13,14-trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dione [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE
PTPN11 and MET	protein tyrosine phosphatase, non-receptor type 11	MET proto-oncogene, receptor tyrosine kinase	Signaling by FGFR in disease Netrin mediated repulsion signals Signaling by EGFRvIII in Cancer Interferon gamma signaling Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Prolactin receptor signaling SHC-mediated signalling PI3K Cascade TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation Spry regulation of FGF signaling Constitutive PI3K/AKT Signaling in Cancer Platelet sensitization by LDL Signaling by VEGF Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction Interleukin-2 signaling PI3K/AKT Signaling in Cancer Frs2-mediated activation Adaptive Immune System Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation PI3K events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Netrin-1 signaling RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade Interferon Signaling CTLA4 inhibitory signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Tie2 Signaling PECAM1 interactions Signaling by FGFR ARMS-mediated activation Nuclear signaling by ERBB4 Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PD-1 signaling PI3K Cascade Signaling by the B Cell Receptor (BCR) Signaling by GPCR FCERI mediated MAPK activation Signaling by SCF-KIT SHC1 events in ERBB2 signaling DAP12 signaling PI-3K cascade Toll Like Receptor 9 (TLR9) Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions Regulation of IFNA signaling GAB1 signalosome GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Signal regulatory protein (SIRP) family interactions Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Platelet homeostasis Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Costimulation by the CD28 family ERK activation PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Interferon alpha/beta signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell surface interactions at the vascular wall ERK2 activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade ERK2 activation Regulation of IFNG signaling	Axon guidance Semaphorin interactions Sema4D mediated inhibition of cell attachment and migration Sema4D in semaphorin signaling	Dodecane-Trimethylamine	K-252a 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide 2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamide 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol 6-{[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine 1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE Cabozantinib
PTPN11 and NTRK2	protein tyrosine phosphatase, non-receptor type 11	neurotrophic tyrosine kinase, receptor, type 2	Signaling by FGFR in disease Netrin mediated repulsion signals Signaling by EGFRvIII in Cancer Interferon gamma signaling Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Prolactin receptor signaling SHC-mediated signalling PI3K Cascade TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation Spry regulation of FGF signaling Constitutive PI3K/AKT Signaling in Cancer Platelet sensitization by LDL Signaling by VEGF Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction Interleukin-2 signaling PI3K/AKT Signaling in Cancer Frs2-mediated activation Adaptive Immune System Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation PI3K events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Netrin-1 signaling RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade Interferon Signaling CTLA4 inhibitory signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Tie2 Signaling PECAM1 interactions Signaling by FGFR ARMS-mediated activation Nuclear signaling by ERBB4 Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PD-1 signaling PI3K Cascade Signaling by the B Cell Receptor (BCR) Signaling by GPCR FCERI mediated MAPK activation Signaling by SCF-KIT SHC1 events in ERBB2 signaling DAP12 signaling PI-3K cascade Toll Like Receptor 9 (TLR9) Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions Regulation of IFNA signaling GAB1 signalosome GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Signal regulatory protein (SIRP) family interactions Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Platelet homeostasis Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Costimulation by the CD28 family ERK activation PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Interferon alpha/beta signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell surface interactions at the vascular wall ERK2 activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade ERK2 activation Regulation of IFNG signaling	Signalling by NGF Activation of TRKA receptors NGF-independant TRKA activation NGF signalling via TRKA from the plasma membrane	Dodecane-Trimethylamine
PTPN11 and RPIA	protein tyrosine phosphatase, non-receptor type 11	ribose 5-phosphate isomerase A	Signaling by FGFR in disease Netrin mediated repulsion signals Signaling by EGFRvIII in Cancer Interferon gamma signaling Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Prolactin receptor signaling SHC-mediated signalling PI3K Cascade TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation Spry regulation of FGF signaling Constitutive PI3K/AKT Signaling in Cancer Platelet sensitization by LDL Signaling by VEGF Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction Interleukin-2 signaling PI3K/AKT Signaling in Cancer Frs2-mediated activation Adaptive Immune System Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation PI3K events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Netrin-1 signaling RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade Interferon Signaling CTLA4 inhibitory signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Tie2 Signaling PECAM1 interactions Signaling by FGFR ARMS-mediated activation Nuclear signaling by ERBB4 Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PD-1 signaling PI3K Cascade Signaling by the B Cell Receptor (BCR) Signaling by GPCR FCERI mediated MAPK activation Signaling by SCF-KIT SHC1 events in ERBB2 signaling DAP12 signaling PI-3K cascade Toll Like Receptor 9 (TLR9) Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions Regulation of IFNA signaling GAB1 signalosome GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Signal regulatory protein (SIRP) family interactions Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Platelet homeostasis Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Costimulation by the CD28 family ERK activation PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Interferon alpha/beta signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell surface interactions at the vascular wall ERK2 activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade ERK2 activation Regulation of IFNG signaling	Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates Pentose phosphate pathway (hexose monophosphate shunt)	Dodecane-Trimethylamine
PTPN11 and FRS3	protein tyrosine phosphatase, non-receptor type 11	fibroblast growth factor receptor substrate 3	Signaling by FGFR in disease Netrin mediated repulsion signals Signaling by EGFRvIII in Cancer Interferon gamma signaling Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Prolactin receptor signaling SHC-mediated signalling PI3K Cascade TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation Spry regulation of FGF signaling Constitutive PI3K/AKT Signaling in Cancer Platelet sensitization by LDL Signaling by VEGF Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction Interleukin-2 signaling PI3K/AKT Signaling in Cancer Frs2-mediated activation Adaptive Immune System Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation PI3K events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Netrin-1 signaling RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade Interferon Signaling CTLA4 inhibitory signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Tie2 Signaling PECAM1 interactions Signaling by FGFR ARMS-mediated activation Nuclear signaling by ERBB4 Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PD-1 signaling PI3K Cascade Signaling by the B Cell Receptor (BCR) Signaling by GPCR FCERI mediated MAPK activation Signaling by SCF-KIT SHC1 events in ERBB2 signaling DAP12 signaling PI-3K cascade Toll Like Receptor 9 (TLR9) Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions Regulation of IFNA signaling GAB1 signalosome GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Signal regulatory protein (SIRP) family interactions Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Platelet homeostasis Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Costimulation by the CD28 family ERK activation PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Interferon alpha/beta signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell surface interactions at the vascular wall ERK2 activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade ERK2 activation Regulation of IFNG signaling	Signaling by FGFR in disease FRS2-mediated cascade Downstream signaling of activated FGFR Signaling by FGFR	Dodecane-Trimethylamine
PTPN11 and TNFRSF1A	protein tyrosine phosphatase, non-receptor type 11	tumor necrosis factor receptor superfamily, member 1A	Signaling by FGFR in disease Netrin mediated repulsion signals Signaling by EGFRvIII in Cancer Interferon gamma signaling Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Prolactin receptor signaling SHC-mediated signalling PI3K Cascade TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation Spry regulation of FGF signaling Constitutive PI3K/AKT Signaling in Cancer Platelet sensitization by LDL Signaling by VEGF Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction Interleukin-2 signaling PI3K/AKT Signaling in Cancer Frs2-mediated activation Adaptive Immune System Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation PI3K events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Netrin-1 signaling RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade Interferon Signaling CTLA4 inhibitory signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Tie2 Signaling PECAM1 interactions Signaling by FGFR ARMS-mediated activation Nuclear signaling by ERBB4 Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PD-1 signaling PI3K Cascade Signaling by the B Cell Receptor (BCR) Signaling by GPCR FCERI mediated MAPK activation Signaling by SCF-KIT SHC1 events in ERBB2 signaling DAP12 signaling PI-3K cascade Toll Like Receptor 9 (TLR9) Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions Regulation of IFNA signaling GAB1 signalosome GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Signal regulatory protein (SIRP) family interactions Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Platelet homeostasis Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Costimulation by the CD28 family ERK activation PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Interferon alpha/beta signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell surface interactions at the vascular wall ERK2 activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade ERK2 activation Regulation of IFNG signaling	TNF signaling Death Receptor Signalling Programmed Cell Death Extrinsic Pathway	Dodecane-Trimethylamine	6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2\',3\':4,5]Pyrrolo[1,2-C]Imidazol-7-One
PTPN11 and CTLA4	protein tyrosine phosphatase, non-receptor type 11	cytotoxic T-lymphocyte-associated protein 4	Signaling by FGFR in disease Netrin mediated repulsion signals Signaling by EGFRvIII in Cancer Interferon gamma signaling Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Prolactin receptor signaling SHC-mediated signalling PI3K Cascade TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation Spry regulation of FGF signaling Constitutive PI3K/AKT Signaling in Cancer Platelet sensitization by LDL Signaling by VEGF Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction Interleukin-2 signaling PI3K/AKT Signaling in Cancer Frs2-mediated activation Adaptive Immune System Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation PI3K events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Netrin-1 signaling RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade Interferon Signaling CTLA4 inhibitory signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Tie2 Signaling PECAM1 interactions Signaling by FGFR ARMS-mediated activation Nuclear signaling by ERBB4 Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PD-1 signaling PI3K Cascade Signaling by the B Cell Receptor (BCR) Signaling by GPCR FCERI mediated MAPK activation Signaling by SCF-KIT SHC1 events in ERBB2 signaling DAP12 signaling PI-3K cascade Toll Like Receptor 9 (TLR9) Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions Regulation of IFNA signaling GAB1 signalosome GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Signal regulatory protein (SIRP) family interactions Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Platelet homeostasis Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Costimulation by the CD28 family ERK activation PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Interferon alpha/beta signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell surface interactions at the vascular wall ERK2 activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade ERK2 activation Regulation of IFNG signaling	Costimulation by the CD28 family CTLA4 inhibitory signaling Adaptive Immune System	Dodecane-Trimethylamine	Alpha-D-Mannose
PTPN11 and FLT4	protein tyrosine phosphatase, non-receptor type 11	fms-related tyrosine kinase 4	Signaling by FGFR in disease Netrin mediated repulsion signals Signaling by EGFRvIII in Cancer Interferon gamma signaling Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Prolactin receptor signaling SHC-mediated signalling PI3K Cascade TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation Spry regulation of FGF signaling Constitutive PI3K/AKT Signaling in Cancer Platelet sensitization by LDL Signaling by VEGF Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction Interleukin-2 signaling PI3K/AKT Signaling in Cancer Frs2-mediated activation Adaptive Immune System Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation PI3K events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Netrin-1 signaling RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade Interferon Signaling CTLA4 inhibitory signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Tie2 Signaling PECAM1 interactions Signaling by FGFR ARMS-mediated activation Nuclear signaling by ERBB4 Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PD-1 signaling PI3K Cascade Signaling by the B Cell Receptor (BCR) Signaling by GPCR FCERI mediated MAPK activation Signaling by SCF-KIT SHC1 events in ERBB2 signaling DAP12 signaling PI-3K cascade Toll Like Receptor 9 (TLR9) Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions Regulation of IFNA signaling GAB1 signalosome GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Signal regulatory protein (SIRP) family interactions Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Platelet homeostasis Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Costimulation by the CD28 family ERK activation PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Interferon alpha/beta signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell surface interactions at the vascular wall ERK2 activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade ERK2 activation Regulation of IFNG signaling	VEGF binds to VEGFR leading to receptor dimerization VEGF ligand-receptor interactions Signaling by VEGF	Dodecane-Trimethylamine	Sorafenib Sunitinib Pazopanib Axitinib Regorafenib

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