Search Results for: Cancer

23406 interactions found:

Symbols Name 1 Name 2
Pathways 1
Pathways 2
Drugs 1
Drugs 2
Diseases 1
Diseases 2
BRCA1 and UBE2T breast cancer 1, early onset ubiquitin-conjugating enzyme E2T
  • ATM mediated phosphorylation of repair proteins
  • Meiotic recombination
  • Fanconi Anemia pathway
  • ATM mediated response to DNA double-strand break
  • Homologous Recombination Repair
  • Meiotic synapsis
  • Homologous recombination repair of replication-independent double-strand breaks
  • Recruitment of repair and signaling proteins to double-strand breaks
  • Double-Strand Break Repair
  • Fanconi Anemia pathway
BRCA1 and SMARCA4 breast cancer 1, early onset SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  • ATM mediated phosphorylation of repair proteins
  • Meiotic recombination
  • Fanconi Anemia pathway
  • ATM mediated response to DNA double-strand break
  • Homologous Recombination Repair
  • Meiotic synapsis
  • Homologous recombination repair of replication-independent double-strand breaks
  • Recruitment of repair and signaling proteins to double-strand breaks
  • Double-Strand Break Repair
  • Chromatin modifying enzymes
  • Chromatin organization
  • misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
  • TCF dependent signaling in response to WNT
  • RNF mutants show enhanced WNT signaling and proliferation
  • formation of the beta-catenin:TCF transactivating complex
  • XAV939 inhibits tankyrase, stabilizing AXIN
  • Signaling by Wnt
  • Signaling by WNT in cancer
  • RMTs methylate histone arginines
BRCA1 and SP1 breast cancer 1, early onset Sp1 transcription factor
  • ATM mediated phosphorylation of repair proteins
  • Meiotic recombination
  • Fanconi Anemia pathway
  • ATM mediated response to DNA double-strand break
  • Homologous Recombination Repair
  • Meiotic synapsis
  • Homologous recombination repair of replication-independent double-strand breaks
  • Recruitment of repair and signaling proteins to double-strand breaks
  • Double-Strand Break Repair
  • Loss of Function of TGFBR2 in Cancer
  • PPARA activates gene expression
  • Metabolism of lipids and lipoproteins
  • Cellular Senescence
  • SMAD2/3 MH2 Domain Mutants in Cancer
  • TGFBR1 LBD Mutants in Cancer
  • Oncogene Induced Senescence
  • SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
  • Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
  • Regulation of cholesterol biosynthesis by SREBP (SREBF)
  • Generic Transcription Pathway
  • TGFBR2 MSI Frameshift Mutants in Cancer
  • Fatty acid, triacylglycerol, and ketone body metabolism
  • SMAD2/3 Phosphorylation Motif Mutants in Cancer
  • Loss of Function of SMAD2/3 in Cancer
  • TGFBR2 Kinase Domain Mutants in Cancer
  • Loss of Function of SMAD4 in Cancer
  • TGFBR1 KD Mutants in Cancer
  • Loss of Function of TGFBR1 in Cancer
  • Signaling by TGF-beta Receptor Complex in Cancer
  • Signaling by TGF-beta Receptor Complex
  • Activation of gene expression by SREBF (SREBP)
  • Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
  • SMAD4 MH2 Domain Mutants in Cancer
BRCA1 and SNX3 breast cancer 1, early onset sorting nexin 3
  • ATM mediated phosphorylation of repair proteins
  • Meiotic recombination
  • Fanconi Anemia pathway
  • ATM mediated response to DNA double-strand break
  • Homologous Recombination Repair
  • Meiotic synapsis
  • Homologous recombination repair of replication-independent double-strand breaks
  • Recruitment of repair and signaling proteins to double-strand breaks
  • Double-Strand Break Repair
  • WNT ligand secretion is abrogated by the PORCN inhibitor LGK974
  • Signaling by Wnt
  • Signaling by WNT in cancer
  • WNT ligand biogenesis and trafficking
BRCA1 and STAT3 breast cancer 1, early onset signal transducer and activator of transcription 3 (acute-phase response factor)
  • ATM mediated phosphorylation of repair proteins
  • Meiotic recombination
  • Fanconi Anemia pathway
  • ATM mediated response to DNA double-strand break
  • Homologous Recombination Repair
  • Meiotic synapsis
  • Homologous recombination repair of replication-independent double-strand breaks
  • Recruitment of repair and signaling proteins to double-strand breaks
  • Double-Strand Break Repair
  • Signaling by PDGF
  • Signalling by NGF
  • Signaling by FGFR in disease
  • Cellular Senescence
  • Interleukin-6 signaling
  • Senescence-Associated Secretory Phenotype (SASP)
  • Cytokine Signaling in Immune system
  • NGF signalling via TRKA from the plasma membrane
  • Signaling by SCF-KIT
  • Signaling by Interleukins
  • Transcriptional regulation of pluripotent stem cells
  • Downstream signal transduction
  • Signaling by FGFR1 mutants
  • Signalling to STAT3
  • Signaling by FGFR mutants
  • Signaling by FGFR1 fusion mutants
  • POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
  • Signaling by Leptin
  • Growth hormone receptor signaling
BRCA1 and BRAP breast cancer 1, early onset BRCA1 associated protein
  • ATM mediated phosphorylation of repair proteins
  • Meiotic recombination
  • Fanconi Anemia pathway
  • ATM mediated response to DNA double-strand break
  • Homologous Recombination Repair
  • Meiotic synapsis
  • Homologous recombination repair of replication-independent double-strand breaks
  • Recruitment of repair and signaling proteins to double-strand breaks
  • Double-Strand Break Repair
BRCA1 and SYT6 breast cancer 1, early onset synaptotagmin VI
  • ATM mediated phosphorylation of repair proteins
  • Meiotic recombination
  • Fanconi Anemia pathway
  • ATM mediated response to DNA double-strand break
  • Homologous Recombination Repair
  • Meiotic synapsis
  • Homologous recombination repair of replication-independent double-strand breaks
  • Recruitment of repair and signaling proteins to double-strand breaks
  • Double-Strand Break Repair
BRCA1 and ASH2L breast cancer 1, early onset ash2 (absent, small, or homeotic)-like (Drosophila)
  • ATM mediated phosphorylation of repair proteins
  • Meiotic recombination
  • Fanconi Anemia pathway
  • ATM mediated response to DNA double-strand break
  • Homologous Recombination Repair
  • Meiotic synapsis
  • Homologous recombination repair of replication-independent double-strand breaks
  • Recruitment of repair and signaling proteins to double-strand breaks
  • Double-Strand Break Repair
  • Chromatin organization
  • misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
  • formation of the beta-catenin:TCF transactivating complex
  • PKMTs methylate histone lysines
  • Signaling by Wnt
  • deactivation of the beta-catenin transactivating complex
  • Chromatin modifying enzymes
  • TCF dependent signaling in response to WNT
  • RNF mutants show enhanced WNT signaling and proliferation
  • XAV939 inhibits tankyrase, stabilizing AXIN
  • Signaling by WNT in cancer
BRCA1 and MSH6 breast cancer 1, early onset mutS homolog 6
  • ATM mediated phosphorylation of repair proteins
  • Meiotic recombination
  • Fanconi Anemia pathway
  • ATM mediated response to DNA double-strand break
  • Homologous Recombination Repair
  • Meiotic synapsis
  • Homologous recombination repair of replication-independent double-strand breaks
  • Recruitment of repair and signaling proteins to double-strand breaks
  • Double-Strand Break Repair
  • Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
  • Mismatch Repair
BRCA1 and TLE4 breast cancer 1, early onset transducin-like enhancer of split 4
  • ATM mediated phosphorylation of repair proteins
  • Meiotic recombination
  • Fanconi Anemia pathway
  • ATM mediated response to DNA double-strand break
  • Homologous Recombination Repair
  • Meiotic synapsis
  • Homologous recombination repair of replication-independent double-strand breaks
  • Recruitment of repair and signaling proteins to double-strand breaks
  • Double-Strand Break Repair
  • Signaling by NOTCH1 HD Domain Mutants in Cancer
  • Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
  • APC truncation mutants have impaired AXIN binding
  • misspliced GSK3beta mutants stabilize beta-catenin
  • T41 mutants of beta-catenin aren't phosphorylated
  • TCF7L2 mutants don't bind CTBP
  • truncated APC mutants destabilize the destruction complex
  • Signaling by Wnt
  • deactivation of the beta-catenin transactivating complex
  • APC truncation mutants are not K63 polyubiquitinated
  • Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
  • S37 mutants of beta-catenin aren't phosphorylated
  • Degradation of beta-catenin by the destruction complex
  • S33 mutants of beta-catenin aren't phosphorylated
  • AXIN mutants destabilize the destruction complex, activating WNT signaling
  • RNF mutants show enhanced WNT signaling and proliferation
  • Signaling by NOTCH1
  • XAV939 inhibits tankyrase, stabilizing AXIN
  • Signaling by NOTCH1 in Cancer
  • truncations of AMER1 destabilize the destruction complex
  • FBXW7 Mutants and NOTCH1 in Cancer
  • misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
  • Signaling by NOTCH
  • formation of the beta-catenin:TCF transactivating complex
  • phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
  • AXIN missense mutants destabilize the destruction complex
  • S45 mutants of beta-catenin aren't phosphorylated
  • repression of WNT target genes
  • NOTCH1 Intracellular Domain Regulates Transcription
  • deletions in the AMER1 gene destabilize the destruction complex
  • AMER1 mutants destabilize the destruction complex
  • TCF dependent signaling in response to WNT
  • deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
  • Signaling by NOTCH1 PEST Domain Mutants in Cancer
  • Signaling by WNT in cancer
BRCA1 and CHEK2 breast cancer 1, early onset checkpoint kinase 2
  • ATM mediated phosphorylation of repair proteins
  • Meiotic recombination
  • Fanconi Anemia pathway
  • ATM mediated response to DNA double-strand break
  • Homologous Recombination Repair
  • Meiotic synapsis
  • Homologous recombination repair of replication-independent double-strand breaks
  • Recruitment of repair and signaling proteins to double-strand breaks
  • Double-Strand Break Repair
BRCA1 and H2AFX breast cancer 1, early onset H2A histone family, member X
  • ATM mediated phosphorylation of repair proteins
  • Meiotic recombination
  • Fanconi Anemia pathway
  • ATM mediated response to DNA double-strand break
  • Homologous Recombination Repair
  • Meiotic synapsis
  • Homologous recombination repair of replication-independent double-strand breaks
  • Recruitment of repair and signaling proteins to double-strand breaks
  • Double-Strand Break Repair
  • RNA Polymerase I Chain Elongation
  • RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
  • Mitotic Prophase
  • Regulatory RNA pathways
  • Deposition of new CENPA-containing nucleosomes at the centromere
  • Cellular Senescence
  • Signaling by Wnt
  • Amyloids
  • NoRC negatively regulates rRNA expression
  • Packaging Of Telomere Ends
  • RNF mutants show enhanced WNT signaling and proliferation
  • Homologous recombination repair of replication-independent double-strand breaks
  • ATM mediated phosphorylation of repair proteins
  • DNA Damage/Telomere Stress Induced Senescence
  • Chromosome Maintenance
  • ATM mediated response to DNA double-strand break
  • misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
  • Chromatin organization
  • formation of the beta-catenin:TCF transactivating complex
  • Meiotic synapsis
  • Senescence-Associated Secretory Phenotype (SASP)
  • Chromatin modifying enzymes
  • Recruitment of repair and signaling proteins to double-strand breaks
  • SIRT1 negatively regulates rRNA Expression
  • Condensation of Prophase Chromosomes
  • MRN complex relocalizes to nuclear foci
  • RNA Polymerase I Promoter Clearance
  • Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
  • M Phase
  • Telomere Maintenance
  • Nucleosome assembly
  • XAV939 inhibits tankyrase, stabilizing AXIN
  • Double-Strand Break Repair
  • DNA methylation
  • Transcriptional regulation by small RNAs
  • Meiotic recombination
  • RNA Polymerase I Transcription
  • Epigenetic regulation of gene expression
  • Negative epigenetic regulation of rRNA expression
  • Cell Cycle, Mitotic
  • PRC2 methylates histones and DNA
  • RMTs methylate histone arginines
  • TCF dependent signaling in response to WNT
  • Oxidative Stress Induced Senescence
  • Homologous Recombination Repair
  • RNA Polymerase I Promoter Opening
  • Signaling by WNT in cancer
BRCA1 and CDK1 breast cancer 1, early onset cyclin-dependent kinase 1
  • ATM mediated phosphorylation of repair proteins
  • Meiotic recombination
  • Fanconi Anemia pathway
  • ATM mediated response to DNA double-strand break
  • Homologous Recombination Repair
  • Meiotic synapsis
  • Homologous recombination repair of replication-independent double-strand breaks
  • Recruitment of repair and signaling proteins to double-strand breaks
  • Double-Strand Break Repair
  • Phosphorylation of the APC/C
  • Signaling by FGFR in disease
  • Phosphorylation of Emi1
  • Signaling by EGFRvIII in Cancer
  • Toll Like Receptor TLR1:TLR2 Cascade
  • Toll Like Receptor 5 (TLR5) Cascade
  • Gastrin-CREB signalling pathway via PKC and MAPK
  • MyD88 dependent cascade initiated on endosome
  • SOS-mediated signalling
  • Mitotic G1-G1/S phases
  • SHC-mediated signalling
  • Recruitment of mitotic centrosome proteins and complexes
  • TRIF-mediated TLR3/TLR4 signaling
  • ERK1 activation
  • Nuclear Pore Complex (NPC) Disassembly
  • APC/C:Cdc20 mediated degradation of mitotic proteins
  • Regulation of APC/C activators between G1/S and early anaphase
  • ERK1 activation
  • APC/C:Cdc20 mediated degradation of Cyclin B
  • Signaling by VEGF
  • Resolution of Sister Chromatid Cohesion
  • Downstream signal transduction
  • Signalling to RAS
  • Toll Like Receptor 3 (TLR3) Cascade
  • Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
  • APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
  • Interleukin-2 signaling
  • Mitotic G2-G2/M phases
  • Frs2-mediated activation
  • MASTL Facilitates Mitotic Progression
  • Axon guidance
  • IRS-mediated signalling
  • G2/M Transition
  • VEGFA-VEGFR2 Pathway
  • Activated TLR4 signalling
  • VEGFR2 mediated cell proliferation
  • GRB2 events in ERBB2 signaling
  • Cyclin A/B1 associated events during G2/M transition
  • Loss of Nlp from mitotic centrosomes
  • MyD88:Mal cascade initiated on plasma membrane
  • TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
  • NCAM signaling for neurite out-growth
  • RAF/MAP kinase cascade
  • Signalling to p38 via RIT and RIN
  • Innate Immune System
  • Condensation of Prometaphase Chromosomes
  • Signaling by Insulin receptor
  • E2F mediated regulation of DNA replication
  • Insulin receptor signalling cascade
  • Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
  • G0 and Early G1
  • Signaling by Ligand-Responsive EGFR Variants in Cancer
  • IRS-related events
  • SHC-related events
  • Signaling by FGFR
  • ARMS-mediated activation
  • Toll-Like Receptors Cascades
  • Toll Like Receptor 10 (TLR10) Cascade
  • Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
  • E2F-enabled inhibition of pre-replication complex formation
  • Regulation of mitotic cell cycle
  • Cell Cycle Checkpoints
  • Signaling by GPCR
  • G2/M Checkpoints
  • Mitotic Prophase
  • Golgi Cisternae Pericentriolar Stack Reorganization
  • FCERI mediated MAPK activation
  • Regulation of PLK1 Activity at G2/M Transition
  • SHC1 events in ERBB2 signaling
  • Signaling by SCF-KIT
  • DAP12 signaling
  • G1/S Transition
  • G1/S-Specific Transcription
  • Toll Like Receptor 9 (TLR9) Cascade
  • G2/M DNA replication checkpoint
  • Signaling by PDGF
  • DAP12 interactions
  • SHC-related events triggered by IGF1R
  • GRB2 events in EGFR signaling
  • Signaling by ERBB4
  • APC/C-mediated degradation of cell cycle proteins
  • Toll Like Receptor 2 (TLR2) Cascade
  • Signaling by ERBB2
  • Signaling by EGFR
  • Signaling by Interleukins
  • SHC1 events in ERBB4 signaling
  • Toll Like Receptor 4 (TLR4) Cascade
  • Fc epsilon receptor (FCERI) signaling
  • Signaling by EGFR in Cancer
  • Condensation of Prophase Chromosomes
  • Signaling by Leptin
  • Signalling to ERKs
  • Mitotic Prometaphase
  • Prolonged ERK activation events
  • Organelle biogenesis and maintenance
  • ERK activation
  • Toll Like Receptor 7/8 (TLR7/8) Cascade
  • Activation of NIMA Kinases NEK9, NEK6, NEK7
  • Nuclear Envelope Breakdown
  • IGF1R signaling cascade
  • Recruitment of NuMA to mitotic centrosomes
  • Cyclin B2 mediated events
  • Toll Like Receptor TLR6:TLR2 Cascade
  • M Phase
  • IRS-related events triggered by IGF1R
  • MyD88 cascade initiated on plasma membrane
  • ERK activation
  • Downstream signaling of activated FGFR
  • Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
  • Signalling by NGF
  • SOS-mediated signalling
  • G2/M DNA damage checkpoint
  • MAP kinase activation in TLR cascade
  • SHC-mediated signalling
  • Depolymerisation of the Nuclear Lamina
  • Assembly of the primary cilium
  • Cytokine Signaling in Immune system
  • NGF signalling via TRKA from the plasma membrane
  • Signaling by Overexpressed Wild-Type EGFR in Cancer
  • MyD88-independent cascade
  • Anchoring of the basal body to the plasma membrane
  • Cell Cycle, Mitotic
  • SHC1 events in EGFR signaling
  • Loss of proteins required for interphase microtubule organization from the centrosome
  • FRS2-mediated cascade
  • IRS-mediated signalling
  • Centrosome maturation
  • Indirubin-3\'-Monoxime
  • Olomoucine
  • Hymenialdisine
  • SU9516
  • Flavopiridol
  • Alsterpaullone
BRCA1 and E2F4 breast cancer 1, early onset E2F transcription factor 4, p107/p130-binding
  • ATM mediated phosphorylation of repair proteins
  • Meiotic recombination
  • Fanconi Anemia pathway
  • ATM mediated response to DNA double-strand break
  • Homologous Recombination Repair
  • Meiotic synapsis
  • Homologous recombination repair of replication-independent double-strand breaks
  • Recruitment of repair and signaling proteins to double-strand breaks
  • Double-Strand Break Repair
  • Loss of Function of TGFBR2 in Cancer
  • SMAD2/3 MH2 Domain Mutants in Cancer
  • TGFBR1 LBD Mutants in Cancer
  • SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
  • Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
  • Generic Transcription Pathway
  • Mitotic G1-G1/S phases
  • TGFBR2 MSI Frameshift Mutants in Cancer
  • SMAD2/3 Phosphorylation Motif Mutants in Cancer
  • Loss of Function of SMAD2/3 in Cancer
  • TGFBR2 Kinase Domain Mutants in Cancer
  • G1 Phase
  • Loss of Function of SMAD4 in Cancer
  • TGFBR1 KD Mutants in Cancer
  • G0 and Early G1
  • Loss of Function of TGFBR1 in Cancer
  • Cell Cycle, Mitotic
  • Cyclin D associated events in G1
  • Signaling by TGF-beta Receptor Complex in Cancer
  • Signaling by TGF-beta Receptor Complex
  • SMAD4 MH2 Domain Mutants in Cancer
BRCA1 and TP53 breast cancer 1, early onset tumor protein p53
  • ATM mediated phosphorylation of repair proteins
  • Meiotic recombination
  • Fanconi Anemia pathway
  • ATM mediated response to DNA double-strand break
  • Homologous Recombination Repair
  • Meiotic synapsis
  • Homologous recombination repair of replication-independent double-strand breaks
  • Recruitment of repair and signaling proteins to double-strand breaks
  • Double-Strand Break Repair
  • Cellular Senescence
  • Activation of BH3-only proteins
  • p53-Dependent G1/S DNA damage checkpoint
  • Oncogene Induced Senescence
  • p53-Dependent G1 DNA Damage Response
  • Formation of Senescence-Associated Heterochromatin Foci (SAHF)
  • Pre-NOTCH Transcription and Translation
  • Stabilization of p53
  • Transcriptional activation of p53 responsive genes
  • Programmed Cell Death
  • Pre-NOTCH Expression and Processing
  • G1/S DNA Damage Checkpoints
  • Intrinsic Pathway for Apoptosis
  • Transcriptional activation of cell cycle inhibitor p21
  • DNA Damage/Telomere Stress Induced Senescence
  • Signaling by NOTCH
  • Factors involved in megakaryocyte development and platelet production
  • Activation of NOXA and translocation to mitochondria
  • Oxidative Stress Induced Senescence
  • Autodegradation of the E3 ubiquitin ligase COP1
  • Activation of PUMA and translocation to mitochondria
  • Cell Cycle Checkpoints
BRCA1 and HDAC2 breast cancer 1, early onset histone deacetylase 2
  • ATM mediated phosphorylation of repair proteins
  • Meiotic recombination
  • Fanconi Anemia pathway
  • ATM mediated response to DNA double-strand break
  • Homologous Recombination Repair
  • Meiotic synapsis
  • Homologous recombination repair of replication-independent double-strand breaks
  • Recruitment of repair and signaling proteins to double-strand breaks
  • Double-Strand Break Repair
  • Signaling by NOTCH1 HD Domain Mutants in Cancer
  • RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
  • Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
  • RNA Polymerase I Transcription Initiation
  • RNA Polymerase I Promoter Clearance
  • Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
  • NoRC negatively regulates rRNA expression
  • Signaling by NOTCH1
  • Signaling by NOTCH1 in Cancer
  • Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
  • FBXW7 Mutants and NOTCH1 in Cancer
  • Signalling by NGF
  • Chromatin organization
  • HDACs deacetylate histones
  • p75NTR negatively regulates cell cycle via SC1
  • RNA Polymerase I Transcription
  • Signaling by NOTCH
  • Epigenetic regulation of gene expression
  • Negative epigenetic regulation of rRNA expression
  • p75 NTR receptor-mediated signalling
  • Factors involved in megakaryocyte development and platelet production
  • NOTCH1 Intracellular Domain Regulates Transcription
  • Chromatin modifying enzymes
  • Signaling by NOTCH1 PEST Domain Mutants in Cancer
  • Constitutive Signaling by NOTCH1 PEST Domain Mutants
BRCA1 and CDK4 breast cancer 1, early onset cyclin-dependent kinase 4
  • ATM mediated phosphorylation of repair proteins
  • Meiotic recombination
  • Fanconi Anemia pathway
  • ATM mediated response to DNA double-strand break
  • Homologous Recombination Repair
  • Meiotic synapsis
  • Homologous recombination repair of replication-independent double-strand breaks
  • Recruitment of repair and signaling proteins to double-strand breaks
  • Double-Strand Break Repair
  • Meiotic recombination
  • Chromatin organization
  • Ubiquitin-dependent degradation of Cyclin D
  • Cellular Senescence
  • G1 Phase
  • Senescence-Associated Secretory Phenotype (SASP)
  • S Phase
  • Oncogene Induced Senescence
  • Cell Cycle, Mitotic
  • Ubiquitin-dependent degradation of Cyclin D1
  • RMTs methylate histone arginines
  • Cyclin D associated events in G1
  • Chromatin modifying enzymes
  • Oxidative Stress Induced Senescence
  • Transcriptional regulation of white adipocyte differentiation
  • Mitotic G1-G1/S phases
BRCA1 and CDK9 breast cancer 1, early onset cyclin-dependent kinase 9
  • ATM mediated phosphorylation of repair proteins
  • Meiotic recombination
  • Fanconi Anemia pathway
  • ATM mediated response to DNA double-strand break
  • Homologous Recombination Repair
  • Meiotic synapsis
  • Homologous recombination repair of replication-independent double-strand breaks
  • Recruitment of repair and signaling proteins to double-strand breaks
  • Double-Strand Break Repair
  • Loss of Function of TGFBR2 in Cancer
  • Formation of HIV-1 elongation complex containing HIV-1 Tat
  • RNA Polymerase II Transcription
  • HIV Infection
  • SMAD2/3 MH2 Domain Mutants in Cancer
  • Tat-mediated elongation of the HIV-1 transcript
  • Tat-mediated HIV elongation arrest and recovery
  • TGFBR1 LBD Mutants in Cancer
  • RNA Polymerase II Pre-transcription Events
  • SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
  • Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
  • HIV elongation arrest and recovery
  • HIV Life Cycle
  • Generic Transcription Pathway
  • HIV Transcription Elongation
  • TGFBR2 MSI Frameshift Mutants in Cancer
  • SMAD2/3 Phosphorylation Motif Mutants in Cancer
  • Loss of Function of SMAD2/3 in Cancer
  • TGFBR2 Kinase Domain Mutants in Cancer
  • Host Interactions of HIV factors
  • Loss of Function of SMAD4 in Cancer
  • Interactions of Tat with host cellular proteins
  • TGFBR1 KD Mutants in Cancer
  • Pausing and recovery of Tat-mediated HIV elongation
  • Loss of Function of TGFBR1 in Cancer
  • Late Phase of HIV Life Cycle
  • Formation of RNA Pol II elongation complex
  • Signaling by TGF-beta Receptor Complex
  • Signaling by TGF-beta Receptor Complex in Cancer
  • Pausing and recovery of HIV elongation
  • Formation of HIV elongation complex in the absence of HIV Tat
  • Transcription of the HIV genome
  • SMAD4 MH2 Domain Mutants in Cancer
  • RNA Polymerase II Transcription Elongation
BRCA1 and LCK breast cancer 1, early onset LCK proto-oncogene, Src family tyrosine kinase
  • ATM mediated phosphorylation of repair proteins
  • Meiotic recombination
  • Fanconi Anemia pathway
  • ATM mediated response to DNA double-strand break
  • Homologous Recombination Repair
  • Meiotic synapsis
  • Homologous recombination repair of replication-independent double-strand breaks
  • Recruitment of repair and signaling proteins to double-strand breaks
  • Double-Strand Break Repair
  • Signaling by the B Cell Receptor (BCR)
  • Signaling by FGFR in disease
  • Signaling by EGFRvIII in Cancer
  • Nef and signal transduction
  • Signaling by SCF-KIT
  • DAP12 signaling
  • Downstream signaling events of B Cell Receptor (BCR)
  • Regulation of KIT signaling
  • PI3K/AKT activation
  • PI-3K cascade
  • Signaling by PDGF
  • DAP12 interactions
  • GAB1 signalosome
  • CD28 co-stimulation
  • Host Interactions of HIV factors
  • CD28 dependent PI3K/Akt signaling
  • The role of Nef in HIV-1 replication and disease pathogenesis
  • Signaling by ERBB4
  • Constitutive PI3K/AKT Signaling in Cancer
  • Role of LAT2/NTAL/LAB on calcium mobilization
  • PI3K events in ERBB4 signaling
  • Signaling by ERBB2
  • Signaling by EGFR
  • Signaling by Interleukins
  • TCR signaling
  • Downstream signal transduction
  • Signaling by EGFR in Cancer
  • Fc epsilon receptor (FCERI) signaling
  • Interleukin-2 signaling
  • PI3K/AKT Signaling in Cancer
  • Platelet activation, signaling and aggregation
  • Adaptive Immune System
  • Downstream TCR signaling
  • Costimulation by the CD28 family
  • PIP3 activates AKT signaling
  • HIV Infection
  • PI3K events in ERBB2 signaling
  • Downstream signaling of activated FGFR
  • Nef Mediated CD4 Down-regulation
  • Innate Immune System
  • Signalling by NGF
  • Generation of second messenger molecules
  • Translocation of ZAP-70 to Immunological synapse
  • Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
  • CTLA4 inhibitory signaling
  • Signaling by Ligand-Responsive EGFR Variants in Cancer
  • Cytokine Signaling in Immune system
  • NGF signalling via TRKA from the plasma membrane
  • Signaling by Overexpressed Wild-Type EGFR in Cancer
  • CD28 dependent Vav1 pathway
  • PECAM1 interactions
  • Cell surface interactions at the vascular wall
  • Signaling by FGFR
  • PD-1 signaling
  • GPVI-mediated activation cascade
  • Phosphorylation of CD3 and TCR zeta chains
  • Dasatinib
  • {4-[2-Acetylamino-2-(3-Carbamoyl-2-Cyclohexylmethoxy-6,7,8,9-Tetrahydro-5h-Benzocyclohepten-5ylcarbamoyl)-Ethyl]-2-Phosphono-Phenyl}-Phosphonic Acid
  • Staurosporine
  • 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
  • (4-{2-Acetylamino-2-[1-(3-Carbamoyl-4-Cyclohexylmethoxy-Phenyl)-Ethylcarbamoyl}-Ethyl}-2-Phosphono-Phenoxy)-Acetic Acid
  • Phosphoaminophosphonic Acid-Adenylate Ester
  • 3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
  • 2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE
  • 5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE
  • N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine
  • N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine
  • N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine
  • Ponatinib
BRCA1 and UBB breast cancer 1, early onset ubiquitin B
  • ATM mediated phosphorylation of repair proteins
  • Meiotic recombination
  • Fanconi Anemia pathway
  • ATM mediated response to DNA double-strand break
  • Homologous Recombination Repair
  • Meiotic synapsis
  • Homologous recombination repair of replication-independent double-strand breaks
  • Recruitment of repair and signaling proteins to double-strand breaks
  • Double-Strand Break Repair
  • Loss of Function of TGFBR2 in Cancer
  • NF-kB is activated and signals survival
  • Signaling by FGFR in disease
  • Hedgehog 'off' state
  • Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
  • Glucose metabolism
  • Toll Like Receptor TLR1:TLR2 Cascade
  • Signaling by NOTCH1
  • Signaling by NOTCH2
  • Toll Like Receptor 5 (TLR5) Cascade
  • AXIN mutants destabilize the destruction complex, activating WNT signaling
  • S33 mutants of beta-catenin aren't phosphorylated
  • Stabilization of p53
  • Removal of licensing factors from origins
  • Switching of origins to a post-replicative state
  • Downregulation of ERBB2:ERBB3 signaling
  • TGFBR2 MSI Frameshift Mutants in Cancer
  • Signaling by NOTCH
  • Endosomal Sorting Complex Required For Transport (ESCRT)
  • Spry regulation of FGF signaling
  • Signaling by NOTCH
  • SCF(Skp2)-mediated degradation of p27/p21
  • deletions in the AMER1 gene destabilize the destruction complex
  • Regulation of innate immune responses to cytosolic DNA
  • Autodegradation of the E3 ubiquitin ligase COP1
  • Toll Like Receptor 3 (TLR3) Cascade
  • Metabolism of carbohydrates
  • CDK-mediated phosphorylation and removal of Cdc6
  • Cellular response to hypoxia
  • Hedgehog ligand biogenesis
  • p75NTR recruits signalling complexes
  • Fanconi Anemia pathway
  • Separation of Sister Chromatids
  • HIV Infection
  • APC truncation mutants have impaired AXIN binding
  • Assembly of the pre-replicative complex
  • Synthesis And Processing Of GAG, GAGPOL Polyproteins
  • Activated TLR4 signalling
  • S37 mutants of beta-catenin aren't phosphorylated
  • p53-Dependent G1 DNA Damage Response
  • regulation of FZD by ubiquitination
  • Signaling by NOTCH1 PEST Domain Mutants in Cancer
  • Signaling by NOTCH1
  • p53-Independent DNA Damage Response
  • MyD88:Mal cascade initiated on plasma membrane
  • Stimuli-sensing channels
  • Membrane binding and targetting of GAG proteins
  • p53-Independent G1/S DNA damage checkpoint
  • G1/S DNA Damage Checkpoints
  • Downregulation of ERBB4 signaling
  • Vpu mediated degradation of CD4
  • Cell death signalling via NRAGE, NRIF and NADE
  • ISG15 antiviral mechanism
  • Interferon Signaling
  • M/G1 Transition
  • p75 NTR receptor-mediated signalling
  • Signaling by FGFR
  • Toll Like Receptor 10 (TLR10) Cascade
  • Signaling by NOTCH1 in Cancer
  • TCF dependent signaling in response to WNT
  • SCF-beta-TrCP mediated degradation of Emi1
  • degradation of AXIN
  • Degradation of GLI1 by the proteasome
  • degradation of DVL
  • Cell Cycle Checkpoints
  • Signaling by WNT in cancer
  • GLI3 is processed to GLI3R by the proteasome
  • Regulation of Apoptosis
  • Degradation of GLI2 by the proteasome
  • Signaling by the B Cell Receptor (BCR)
  • Vif-mediated degradation of APOBEC3G
  • Signaling by NOTCH1 HD Domain Mutants in Cancer
  • Constitutive Signaling by NOTCH1 HD Domain Mutants
  • Downregulation of TGF-beta receptor signaling
  • truncated APC mutants destabilize the destruction complex
  • Cyclin E associated events during G1/S transition
  • TGF-beta receptor signaling activates SMADs
  • Regulation of PLK1 Activity at G2/M Transition
  • FCERI mediated NF-kB activation
  • Regulation of the Fanconi anemia pathway
  • Generic Transcription Pathway
  • G1/S Transition
  • Toll Like Receptor 9 (TLR9) Cascade
  • FBXW7 Mutants and NOTCH1 in Cancer
  • IRAK1 recruits IKK complex
  • Negative regulation of FGFR signaling
  • truncations of AMER1 destabilize the destruction complex
  • EGFR downregulation
  • TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
  • IRAK2 mediated activation of TAK1 complex
  • Processing-defective Hh variants abrogate ligand secretion
  • Regulation of activated PAK-2p34 by proteasome mediated degradation
  • Host Interactions of HIV factors
  • phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
  • Signaling by ERBB4
  • Antiviral mechanism by IFN-stimulated genes
  • Fc epsilon receptor (FCERI) signaling
  • Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
  • Interleukin-3, 5 and GM-CSF signaling
  • TAK1 activates NFkB by phosphorylation and activation of IKKs complex
  • M Phase
  • APC truncation mutants are not K63 polyubiquitinated
  • Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
  • HIV Life Cycle
  • Budding and maturation of HIV virion
  • Hedgehog 'on' state
  • Programmed Cell Death
  • Class I MHC mediated antigen processing & presentation
  • IKK complex recruitment mediated by RIP1
  • MAP kinase activation in TLR cascade
  • Regulation of DNA replication
  • Cytokine Signaling in Immune system
  • Signaling by Overexpressed Wild-Type EGFR in Cancer
  • MyD88-independent cascade
  • Cell Cycle, Mitotic
  • Signaling by TGF-beta Receptor Complex in Cancer
  • Oxidative Stress Induced Senescence
  • Activation of NF-kappaB in B cells
  • Asymmetric localization of PCP proteins
  • deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
  • TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
  • IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
  • TRAF6 mediated induction of TAK1 complex
  • Negative regulators of RIG-I/MDA5 signaling
  • misspliced GSK3beta mutants stabilize beta-catenin
  • Hh ligand biogenesis disease
  • SMAD2/3 MH2 Domain Mutants in Cancer
  • T41 mutants of beta-catenin aren't phosphorylated
  • Cellular Senescence
  • Signaling by NOTCH1 HD Domain Mutants in Cancer
  • Signaling by EGFRvIII in Cancer
  • Assembly Of The HIV Virion
  • Downstream signaling events of B Cell Receptor (BCR)
  • Degradation of beta-catenin by the destruction complex
  • NOD1/2 Signaling Pathway
  • Glycogen storage diseases
  • MyD88 dependent cascade initiated on endosome
  • Mitotic G1-G1/S phases
  • activated TAK1 mediates p38 MAPK activation
  • Regulation of mRNA stability by proteins that bind AU-rich elements
  • misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
  • TRIF-mediated TLR3/TLR4 signaling
  • DNA Replication Pre-Initiation
  • Senescence-Associated Secretory Phenotype (SASP)
  • APC/C:Cdc20 mediated degradation of mitotic proteins
  • TGFBR1 KD Mutants in Cancer
  • S45 mutants of beta-catenin aren't phosphorylated
  • Regulation of APC/C activators between G1/S and early anaphase
  • Late Phase of HIV Life Cycle
  • APC/C:Cdc20 mediated degradation of Cyclin B
  • NOTCH2 Activation and Transmission of Signal to the Nucleus
  • TCR signaling
  • AMER1 mutants destabilize the destruction complex
  • Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
  • Interleukin-1 signaling
  • APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
  • PCP/CE pathway
  • Mitotic G2-G2/M phases
  • Adaptive Immune System
  • APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
  • Regulation of Hypoxia-inducible Factor (HIF) by oxygen
  • Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
  • Ubiquitin-dependent degradation of Cyclin D
  • G2/M Transition
  • TGFBR1 LBD Mutants in Cancer
  • Oncogene Induced Senescence
  • Autodegradation of Cdh1 by Cdh1:APC/C
  • Ion channel transport
  • p75NTR signals via NF-kB
  • Regulation of signaling by CBL
  • XAV939 inhibits tankyrase, stabilizing AXIN
  • Disease
  • TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
  • Signal Transduction
  • Innate Immune System
  • Synthesis of DNA
  • Loss of Function of SMAD2/3 in Cancer
  • TGFBR2 Kinase Domain Mutants in Cancer
  • G1 Phase
  • Signaling by Ligand-Responsive EGFR Variants in Cancer
  • Loss of Function of TGFBR1 in Cancer
  • Ubiquitin-dependent degradation of Cyclin D1
  • Activated NOTCH1 Transmits Signal to the Nucleus
  • NOTCH1 Intracellular Domain Regulates Transcription
  • Toll-Like Receptors Cascades
  • Cyclin D associated events in G1
  • Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
  • Regulation of mitotic cell cycle
  • Signaling by Hedgehog
  • Association of licensing factors with the pre-replicative complex
  • IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
  • Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
  • TCF7L2 mutants don't bind CTBP
  • p53-Dependent G1/S DNA damage checkpoint
  • Signaling by Wnt
  • AUF1 (hnRNP D0) destabilizes mRNA
  • Downregulation of SMAD2/3:SMAD4 transcriptional activity
  • APC/C:Cdc20 mediated degradation of Securin
  • SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
  • CDK-mediated phosphorylation and removal of Cdc6
  • Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
  • IRAK1 recruits IKK complex
  • Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
  • RNF mutants show enhanced WNT signaling and proliferation
  • Myoclonic epilepsy of Lafora
  • Signaling by NOTCH1 in Cancer
  • SMAD2/3 Phosphorylation Motif Mutants in Cancer
  • IRAK2 mediated activation of TAK1 complex
  • Loss of Function of SMAD4 in Cancer
  • AXIN missense mutants destabilize the destruction complex
  • S Phase
  • APC/C-mediated degradation of cell cycle proteins
  • Toll Like Receptor 2 (TLR2) Cascade
  • Signaling by ERBB2
  • Signaling by EGFR
  • Signaling by Interleukins
  • Glycogen synthesis
  • NRIF signals cell death from the nucleus
  • Toll Like Receptor 4 (TLR4) Cascade
  • Signaling by EGFR in Cancer
  • Signaling by NOTCH1 PEST Domain Mutants in Cancer
  • SCF(Skp2)-mediated degradation of p27/p21
  • Cyclin A:Cdk2-associated events at S phase entry
  • Constitutive Signaling by NOTCH1 PEST Domain Mutants
  • Mitotic Metaphase and Anaphase
  • Downstream TCR signaling
  • Antigen processing: Ubiquitination & Proteasome degradation
  • Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
  • Toll Like Receptor 7/8 (TLR7/8) Cascade
  • Orc1 removal from chromatin
  • Mitotic Anaphase
  • deactivation of the beta-catenin transactivating complex
  • Toll Like Receptor TLR6:TLR2 Cascade
  • MyD88 cascade initiated on plasma membrane
  • Activated NOTCH1 Transmits Signal to the Nucleus
  • Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
  • FBXW7 Mutants and NOTCH1 in Cancer
  • JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
  • Signalling by NGF
  • Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
  • Cytosolic sensors of pathogen-associated DNA
  • beta-catenin independent WNT signaling
  • RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
  • Orc1 removal from chromatin
  • Signaling by TGF-beta Receptor Complex
  • CDT1 association with the CDC6:ORC:origin complex
  • Antigen processing-Cross presentation
  • ER-Phagosome pathway
  • SMAD4 MH2 Domain Mutants in Cancer

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