Diabetes - Wiki-Pi

Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide
AVPR2 and GNAS	arginine vasopressin receptor 2	GNAS complex locus	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Vasopressin-like receptors G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes Aquaporin-mediated transport GPCR ligand binding GPCR downstream signaling Peptide ligand-binding receptors	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Hedgehog 'off' state G alpha (s) signalling events Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes G alpha (z) signalling events G alpha (i) signalling events Class B/2 (Secretin family receptors) Glucagon signaling in metabolic regulation Prostacyclin signalling through prostacyclin receptor PKA activation in glucagon signalling Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding Aquaporin-mediated transport GPCR downstream signaling Platelet homeostasis Signaling by Hedgehog	Desmopressin Vasopressin Conivaptan Terlipressin Tolvaptan
AVPR2 and GNB1	arginine vasopressin receptor 2	guanine nucleotide binding protein (G protein), beta polypeptide 1	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Vasopressin-like receptors G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes Aquaporin-mediated transport GPCR ligand binding GPCR downstream signaling Peptide ligand-binding receptors	Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Olfactory Signaling Pathway Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Diseases associated with visual transduction Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade G beta:gamma signalling through PI3Kgamma The phototransduction cascade G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Visual phototransduction Ca2+ pathway G-protein activation	Desmopressin Vasopressin Conivaptan Terlipressin Tolvaptan
AXL and PTPN11	AXL receptor tyrosine kinase	protein tyrosine phosphatase, non-receptor type 11	Signaling by VEGF VEGFA-VEGFR2 Pathway	Signaling by FGFR in disease Netrin mediated repulsion signals Signaling by EGFRvIII in Cancer Interferon gamma signaling Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Prolactin receptor signaling SHC-mediated signalling PI3K Cascade TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation Spry regulation of FGF signaling Constitutive PI3K/AKT Signaling in Cancer Platelet sensitization by LDL Signaling by VEGF Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction Interleukin-2 signaling PI3K/AKT Signaling in Cancer Frs2-mediated activation Adaptive Immune System Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation PI3K events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Netrin-1 signaling RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade Interferon Signaling CTLA4 inhibitory signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Tie2 Signaling PECAM1 interactions Signaling by FGFR ARMS-mediated activation Nuclear signaling by ERBB4 Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PD-1 signaling PI3K Cascade Signaling by the B Cell Receptor (BCR) Signaling by GPCR FCERI mediated MAPK activation Signaling by SCF-KIT SHC1 events in ERBB2 signaling DAP12 signaling PI-3K cascade Toll Like Receptor 9 (TLR9) Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions Regulation of IFNA signaling GAB1 signalosome GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Signal regulatory protein (SIRP) family interactions Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Platelet homeostasis Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Costimulation by the CD28 family ERK activation PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Interferon alpha/beta signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell surface interactions at the vascular wall ERK2 activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade ERK2 activation Regulation of IFNG signaling		Dodecane-Trimethylamine
AXL and SRC	AXL receptor tyrosine kinase	SRC proto-oncogene, non-receptor tyrosine kinase	Signaling by VEGF VEGFA-VEGFR2 Pathway	Signaling by ERBB2		Dasatinib RU84687 RU79256 N6-Benzyl Adenosine-5\'-Diphosphate RU85493 RU78262 Phosphonotyrosine Malonic acid RU83876 RU90395 RU79072 RU78783 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine PASBN RU82129 PAS219 DPI59 RU82197 Phenylphosphate RU78300 RU79073 RU82209 ISO24 RU85053 RU78299 Oxalic Acid RU78191 Citric Acid RU81843 4-[(4-METHYL-1-PIPERAZINYL)METHYL]-N-[3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-BENZAMIDE Purvalanol A Bosutinib 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-phenylurea 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 1-(1-methylethyl)-3-quinolin-6-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 2-(4-CARCOXY-5-ISOPROPYLTHIAZOLYL)BENZOPIPERIDINE N-(4-PHENYLAMINO-QUINAZOLIN-6-YL)-ACRYLAMIDE (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide Ponatinib
BCL2 and BLK	B-cell CLL/lymphoma 2	BLK proto-oncogene, Src family tyrosine kinase	Activation of BAD and translocation to mitochondria Inflammasomes The NLRP1 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Programmed Cell Death Activation of BH3-only proteins BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Innate Immune System Intrinsic Pathway for Apoptosis	Signaling by the B Cell Receptor (BCR) Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System	Ibuprofen Paclitaxel Docetaxel Rasagiline
BCL2 and CDK2	B-cell CLL/lymphoma 2	cyclin-dependent kinase 2	Activation of BAD and translocation to mitochondria Inflammasomes The NLRP1 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Programmed Cell Death Activation of BH3-only proteins BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Innate Immune System Intrinsic Pathway for Apoptosis	CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Activation of the pre-replicative complex Cellular Senescence Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes G2/M Transition p53-Dependent G1/S DNA damage checkpoint Activation of the pre-replicative complex Orc1 removal from chromatin Cyclin E associated events during G1/S transition CDK-mediated phosphorylation and removal of Cdc6 p53-Dependent G1 DNA Damage Response Cyclin A/B1 associated events during G2/M transition G2 Phase Activation of ATR in response to replication stress G1/S Transition Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state G1/S DNA Damage Checkpoints Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Synthesis of DNA DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Senescence-Associated Secretory Phenotype (SASP) G0 and Early G1 S Phase Regulation of APC/C activators between G1/S and early anaphase Factors involved in megakaryocyte development and platelet production Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins SCF(Skp2)-mediated degradation of p27/p21 Orc1 removal from chromatin Regulation of mitotic cell cycle Cell Cycle Checkpoints SCF(Skp2)-mediated degradation of p27/p21 Cyclin A:Cdk2-associated events at S phase entry Mitotic G2-G2/M phases	Ibuprofen Paclitaxel Docetaxel Rasagiline	Double Oxidized Cysteine 4-[5-(Trans-4-Aminocyclohexylamino)-3-Isopropylpyrazolo[1,5-a]Pyrimidin-7-Ylamino]-N,N-Dimethylbenzenesulfonamide Staurosporine Indirubin-3\'-Monoxime 4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Ylamine Olomoucine 4-[(4-Imidazo[1,2-a]Pyridin-3-Ylpyrimidin-2-Yl)Amino]Benzenesulfonamide 2-Amino-6-Chloropyrazine 6-O-Cyclohexylmethyl Guanine N-[4-(2-Methylimidazo[1,2-a]Pyridin-3-Yl)-2-Pyrimidinyl]Acetamide 1-Amino-6-Cyclohex-3-Enylmethyloxypurine N-(5-Cyclopropyl-1h-Pyrazol-3-Yl)Benzamide Purvalanol [4-(2-Amino-4-Methyl-Thiazol-5-Yl)-Pyrimidin-2-Yl]-(3-Nitro-Phenyl)-Amine 5-{[(2-Amino-9h-Purin-6-Yl)Oxy]Methyl}-2-Pyrrolidinone 4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Yl]-(4-Trifluoromethyl-Phenyl)-Amine Hymenialdisine (5-Chloropyrazolo[1,5-a]Pyrimidin-7-Yl)-(4-Methanesulfonylphenyl)Amine 4-(5-Bromo-2-Oxo-2h-Indol-3-Ylazo)-Benzenesulfonamide 4-(2,5-Dichloro-Thiophen-3-Yl)-Pyrimidin-2-Ylamine 4-[(6-Amino-4-Pyrimidinyl)Amino]Benzenesulfonamide 4-[3-Hydroxyanilino]-6,7-Dimethoxyquinazoline SU9516 3-Pyridin-4-Yl-2,4-Dihydro-Indeno[1,2-.C.]Pyrazole Flavopiridol (2e,3s)-3-Hydroxy-5\'-[(4-Hydroxypiperidin-1-Yl)Sulfonyl]-3-Methyl-1,3-Dihydro-2,3\'-Biindol-2\'(1\'h)-One 1-[(2-Amino-6,9-Dihydro-1h-Purin-6-Yl)Oxy]-3-Methyl-2-Butanol 4-((3r,4s,5r)-4-Amino-3,5-Dihydroxy-Hex-1-Ynyl)-5-Fluoro-3-[1-(3-Methoxy-1h-Pyrrol-2-Yl)-Meth-(Z)-Ylidene]-1,3-Dihydro-Indol-2-One Lysine Nz-Carboxylic Acid [2-Amino-6-(2,6-Difluoro-Benzoyl)-Imidazo[1,2-a]Pyridin-3-Yl]-Phenyl-Methanone Alsterpaullone N-[4-(2,4-Dimethyl-1,3-Thiazol-5-Yl)Pyrimidin-2-Yl]-N\'-Hydroxyimidoformamide N\'-(Pyrrolidino[2,1-B]Isoindolin-4-On-8-Yl)-N-(Pyridin-2-Yl)Urea 2-[Trans-(4-Aminocyclohexyl)Amino]-6-(Benzyl-Amino)-9-Cyclopentylpurine 4-[4-(4-Methyl-2-Methylamino-Thiazol-5-Yl)-Pyrimidin-2-Ylamino]-Phenol 3-[4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Ylamino]-Phenol PHENYLAMINOIMIDAZO(1,2-ALPHA)PYRIDINE OLOMOUCINE II TRIAZOLOPYRIMIDINE Bosutinib 4-[(7-OXO-7H-THIAZOLO[5,4-E]INDOL-8-YLMETHYL)-AMINO]-N-PYRIDIN-2-YL-BENZENESULFONAMIDE (13R,15S)-13-METHYL-16-OXA-8,9,12,22,24-PENTAAZAHEXACYCLO[15.6.2.16,9.1,12,15.0,2,7.0,21,25]HEPTACOSA-1(24),2,4,6,17(25),18,20-HEPTAENE-23,26-DIONE N-(3-CYCLOPROPYL-1H-PYRAZOL-5-YL)-2-(2-NAPHTHYL)ACETAMIDE 2-ANILINO-6-CYCLOHEXYLMETHOXYPURINE 1-(5-OXO-2,3,5,9B-TETRAHYDRO-1H-PYRROLO[2,1-A]ISOINDOL-9-YL)-3-(5-PYRROLIDIN-2-YL-1H-PYRAZOL-3-YL)-UREA (5-phenyl-7-(pyridin-3-ylmethylamino)pyrazolo[1,5-a]pyrimidin-3-yl)methanol 2-(3,4-DIHYDROXYPHENYL)-8-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-3-HYDROXY-6-METHYL-4H-CHROMEN-4-ONE (2R)-1-(DIMETHYLAMINO)-3-{4-[(6-{[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-4-YL)AMINO]PHENOXY}PROPAN-2-OL 5-(2,3-dichlorophenyl)-N-(pyridin-4-ylmethyl)-3-thiocyanatopyrazolo[1,5-a]pyrimidin-7-amine O6-CYCLOHEXYLMETHOXY-2-(4\'-SULPHAMOYLANILINO) PURINE (2S)-N-[(3Z)-5-CYCLOPROPYL-3H-PYRAZOL-3-YLIDENE]-2-[4-(2-OXOIMIDAZOLIDIN-1-YL)PHENYL]PROPANAMIDE 5-[(2-AMINOETHYL)AMINO]-6-FLUORO-3-(1H-PYRROL-2-YL)BENZO[CD]INDOL-2(1H)-ONE N-cyclopropyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amine 3-((3-bromo-5-o-tolylpyrazolo[1,5-a]pyrimidin-7-ylamino)methyl)pyridine 1-oxide 6-CYCLOHEXYLMETHOXY-2-(3\'-CHLOROANILINO) PURINE 3-bromo-5-phenyl-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine N-[5-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-1H-INDAZOL-3-YL]-2-(4-PIPERIDIN-1-YLPHENYL)ACETAMIDE (3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-one 5-[5,6-BIS(METHYLOXY)-1H-BENZIMIDAZOL-1-YL]-3-{[1-(2-CHLOROPHENYL)ETHYL]OXY}-2-THIOPHENECARBOXAMIDE (2Z)-5\'-BROMO-2,3\'-BIINDOLE-2\',3(1H,1\'H)-DIONE AMMONIATE (2S)-1-{4-[(4-ANILINO-5-BROMOPYRIMIDIN-2-YL)AMINO]PHENOXY}-3-(DIMETHYLAMINO)PROPAN-2-OL (2R)-1-{4-[(4-ANILINO-5-BROMOPYRIMIDIN-2-YL)AMINO]PHENOXY}-3-(DIMETHYLAMINO)PROPAN-2-OL 2-IMINO-5-(1-PYRIDIN-2-YL-METH-(E)-YLIDENE)-1,3-THIAZOLIDIN-4-ONE 4-{5-[(Z)-(2,4-DIOXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZENESULFONAMIDE 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]-2-FURYL}-N-METHYLBENZENESULFONAMIDE 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZENESULFONAMIDE 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}-2-(TRIFLUOROMETHYL)BENZENESULFONAMIDE 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZOIC ACID 4-{5-[(1Z)-1-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)ETHYL]-2-FURYL}BENZENESULFONAMIDE N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N\',N\'-DIMETHYL-BENZENE-1,4-DIAMINE (5Z)-5-(3-BROMOCYCLOHEXA-2,5-DIEN-1-YLIDENE)-N-(PYRIDIN-4-YLMETHYL)-1,5-DIHYDROPYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE 6-(3,4-DIHYDROXYBENZYL)-3-ETHYL-1-(2,4,6-TRICHLOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4(5H)-ONE 6-(3-AMINOPHENYL)-N-(TERT-BUTYL)-2-(TRIFLUOROMETHYL)QUINAZOLIN-4-AMINE 2-(4-(AMINOMETHYL)PIPERIDIN-1-YL)-N-(3_CYCLOHEXYL-4-OXO-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-5-YL)ACETAMIDE 1-(3-(2,4-DIMETHYLTHIAZOL-5-YL)-4-OXO-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-5-YL)-3-(4-METHYLPIPERAZIN-1-YL)UREA 4-{[5-(CYCLOHEXYLMETHOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE 4-{[5-(CYCLOHEXYLAMINO)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE 4-({5-[(4-AMINOCYCLOHEXYL)AMINO][1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL}AMINO)BENZENESULFONAMIDE 4-{[5-(CYCLOHEXYLOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE 4-[(E)-(3,5-DIAMINO-1H-PYRAZOL-4-YL)DIAZENYL]PHENOL (2R)-1-[4-({4-[(2,5-DICHLOROPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENOXY]-3-(DIMETHYLAMINO)PROPAN-2-OL (2S)-1-[4-({6-[(2,6-DIFLUOROPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)PHENOXY]-3-(DIMETHYLAMINO)PROPAN-2-OL (2S)-1-[4-({4-[(2,5-DICHLOROPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENOXY]-3-(DIMETHYLAMINO)PROPAN-2-OL (2R)-1-[4-({6-[(2,6-DIFLUOROPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)PHENOXY]-3-(DIMETHYLAMINO)PROPAN-2-OL N-(2-METHOXYETHYL)-4-({4-[2-METHYL-1-(1-METHYLETHYL)-1H-IMIDAZOL-5-YL]PYRIMIDIN-2-YL}AMINO)BENZENESULFONAMIDE 4-{[4-(1-CYCLOPROPYL-2-METHYL-1H-IMIDAZOL-5-YL)PYRIMIDIN-2-YL]AMINO}-N-METHYLBENZENESULFONAMIDE 1-(3,5-DICHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID 1-(DIMETHYLAMINO)-3-(4-{{4-(2-METHYLIMIDAZO[1,2-A]PYRIDIN-3-YL)PYRIMIDIN-2-YL]AMINO}PHENOXY)PROPAN-2-OL N-(4-{[(3S)-3-(dimethylamino)pyrrolidin-1-yl]carbonyl}phenyl)-5-fluoro-4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]pyrimidin-2-amine 2-{4-[4-({4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]pyrimidin-2-yl}amino)phenyl]piperazin-1-yl}-2-oxoethanol N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE (4-AMINO-2-{[1-(METHYLSULFONYL)PIPERIDIN-4-YL]AMINO}PYRIMIDIN-5-YL)(2,3-DIFLUORO-6-METHOXYPHENYL)METHANONE N-METHYL-4-{[(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDE N-METHYL-{4-[2-(7-OXO-6,7-DIHYDRO-8H-[1,3]THIAZOLO[5,4-E]INDOL-8-YLIDENE)HYDRAZINO]PHENYL}METHANESULFONAMIDE 3-{[(2,2-DIOXIDO-1,3-DIHYDRO-2-BENZOTHIEN-5-YL)AMINO]METHYLENE}-5-(1,3-OXAZOL-5-YL)-1,3-DIHYDRO-2H-INDOL-2-ONE 4-{[(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]AMINO}-N-(1,3-THIAZOL-2-YL)BENZENESULFONAMIDE 3-{[4-([AMINO(IMINO)METHYL]AMINOSULFONYL)ANILINO]METHYLENE}-2-OXO-2,3-DIHYDRO-1H-INDOLE 5-hydroxynaphthalene-1-sulfonamide N-(4-sulfamoylphenyl)-1H-indazole-3-carboxamide 4-[(6-chloropyrazin-2-yl)amino]benzenesulfonamide N-phenyl-1H-pyrazole-3-carboxamide 4-(acetylamino)-N-(4-fluorophenyl)-1H-pyrazole-3-carboxamide (4E)-N-(4-fluorophenyl)-4-[(phenylcarbonyl)imino]-4H-pyrazole-3-carboxamide {[(2,6-difluorophenyl)carbonyl]amino}-N-(4-fluorophenyl)-1H-pyrazole-3-carboxamide 5-chloro-7-[(1-methylethyl)amino]pyrazolo[1,5-a]pyrimidine-3-carbonitrile 5-[(4-AMINOCYCLOHEXYL)AMINO]-7-(PROPAN-2-YLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE 4-{[(2,6-difluorophenyl)carbonyl]amino}-N-[(3S)-piperidin-3-yl]-1H-pyrazole-3-carboxamide 4-{[(2,6-dichlorophenyl)carbonyl]amino}-N-piperidin-4-yl-1H-pyrazole-3-carboxamide 4-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine 4-(4-propoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine HYDROXY(OXO)(3-{[(2Z)-4-[3-(1H-1,2,4-TRIAZOL-1-YLMETHYL)PHENYL]PYRIMIDIN-2(5H)-YLIDENE]AMINO}PHENYL)AMMONIUM 4-METHYL-5-{(2E)-2-[(4-MORPHOLIN-4-YLPHENYL)IMINO]-2,5-DIHYDROPYRIMIDIN-4-YL}-1,3-THIAZOL-2-AMINE 6-CYCLOHEXYLMETHYLOXY-2-(4\'-HYDROXYANILINO)PURINE 4-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)--BENZAMIDE 6-(CYCLOHEXYLMETHOXY)-8-ISOPROPYL-9H-PURIN-2-AMINE 3-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)-BENZENESULFONAMIDE (2R)-2-{[4-(benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-ol 3-({2-[(4-{[6-(CYCLOHEXYLMETHOXY)-9H-PURIN-2-YL]AMINO}PHENYL)SULFONYL]ETHYL}AMINO)PROPAN-1-OL 6-CYCLOHEXYLMETHYLOXY-5-NITROSO-PYRIMIDINE-2,4-DIAMINE 1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid 6-BROMO-13-THIA-2,4,8,12,19-PENTAAZATRICYCLO[12.3.1.1~3,7~]NONADECA-1(18),3(19),4,6,14,16-HEXAENE 13,13-DIOXIDE (2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol 1-[4-(AMINOSULFONYL)PHENYL]-1,6-DIHYDROPYRAZOLO[3,4-E]INDAZOLE-3-CARBOXAMIDE 5-(2,3-dichlorophenyl)-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine 6-(2-fluorophenyl)-N-(pyridin-3-ylmethyl)imidazo[1,2-a]pyrazin-8-amine 3-methyl-N-(pyridin-4-ylmethyl)imidazo[1,2-a]pyrazin-8-amine 5-(2-fluorophenyl)-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine 3-bromo-5-phenyl-N-(pyridin-3-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine 3-bromo-5-phenyl-N-(pyrimidin-5-ylmethyl)pyrazolo[1,5-a]pyridin-7-amine 3-bromo-6-phenyl-N-(pyrimidin-5-ylmethyl)imidazo[1,2-a]pyridin-8-amine N-((2-aminopyrimidin-5-yl)methyl)-5-(2,6-difluorophenyl)-3-ethylpyrazolo[1,5-a]pyrimidin-7-amine 3-cyclopropyl-5-phenyl-N-(pyridin-3-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine 4-{[4-AMINO-6-(CYCLOHEXYLMETHOXY)-5-NITROSOPYRIMIDIN-2-YL]AMINO}BENZAMIDE 4-[(5-ISOPROPYL-1,3-THIAZOL-2-YL)AMINO]BENZENESULFONAMIDE N-(5-ISOPROPYL-THIAZOL-2-YL)-2-PYRIDIN-3-YL-ACETAMIDE 9-amino-5-(2-aminopyrimidin-4-yl)pyrido[3\',2\':4,5]pyrrolo[1,2-c]pyrimidin-4-ol N-(3-METHYLBUT-2-EN-1-YL)-9H-PURIN-6-AMINE
BCL2L1 and IRS1	BCL2-like 1	insulin receptor substrate 1	Inflammasomes The NLRP1 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Programmed Cell Death BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Innate Immune System Intrinsic Pathway for Apoptosis	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade SOS-mediated signalling PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Signaling by Leptin Growth hormone receptor signaling Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS activation PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling Signal attenuation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade		[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID
BCL2L1 and BLK	BCL2-like 1	BLK proto-oncogene, Src family tyrosine kinase	Inflammasomes The NLRP1 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Programmed Cell Death BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Innate Immune System Intrinsic Pathway for Apoptosis	Signaling by the B Cell Receptor (BCR) Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System
BCL2L2 and TCF4	BCL2-like 2	transcription factor 4		CDO in myogenesis Myogenesis
BCL3 and TBP	B-cell CLL/lymphoma 3	TATA box binding protein		RNA Polymerase II Promoter Escape RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation RNA Polymerase II Transcription RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HIV Infection RNA Polymerase II Pre-transcription Events HIV Life Cycle HIV Transcription Initiation NoRC negatively regulates rRNA expression RNA Polymerase II HIV Promoter Escape RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase I Transcription RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Late Phase of HIV Life Cycle RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation SIRT1 negatively regulates rRNA Expression Transcription of the HIV genome
BCL6 and HDAC9	B-cell CLL/lymphoma 6	histone deacetylase 9		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer		Valproic Acid
BCL6 and BCL11A	B-cell CLL/lymphoma 6	B-cell CLL/lymphoma 11A (zinc finger protein)
BCL6 and PPARD	B-cell CLL/lymphoma 6	peroxisome proliferator-activated receptor delta		Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Signaling by Retinoic Acid Import of palmitoyl-CoA into the mitochondrial matrix Pyruvate metabolism and Citric Acid (TCA) cycle Nuclear Receptor transcription pathway The citric acid (TCA) cycle and respiratory electron transport		Icosapent Treprostinil Sulindac Bezafibrate Heptyl-Beta-D-Glucopyranoside (11E)-OCTADEC-11-ENOIC ACID (2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acid 2-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acid 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid {4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy}acetic acid
BCR and BLK	breakpoint cluster region	BLK proto-oncogene, Src family tyrosine kinase	Rho GTPase cycle Signaling by FGFR in disease Signaling by Rho GTPases Signaling by FGFR1 mutants Signaling by FGFR mutants Signaling by FGFR1 fusion mutants	Signaling by the B Cell Receptor (BCR) Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System
BCR and SRC	breakpoint cluster region	SRC proto-oncogene, non-receptor tyrosine kinase	Rho GTPase cycle Signaling by FGFR in disease Signaling by Rho GTPases Signaling by FGFR1 mutants Signaling by FGFR mutants Signaling by FGFR1 fusion mutants	Signaling by ERBB2		Dasatinib RU84687 RU79256 N6-Benzyl Adenosine-5\'-Diphosphate RU85493 RU78262 Phosphonotyrosine Malonic acid RU83876 RU90395 RU79072 RU78783 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine PASBN RU82129 PAS219 DPI59 RU82197 Phenylphosphate RU78300 RU79073 RU82209 ISO24 RU85053 RU78299 Oxalic Acid RU78191 Citric Acid RU81843 4-[(4-METHYL-1-PIPERAZINYL)METHYL]-N-[3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-BENZAMIDE Purvalanol A Bosutinib 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-phenylurea 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 1-(1-methylethyl)-3-quinolin-6-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 2-(4-CARCOXY-5-ISOPROPYLTHIAZOLYL)BENZOPIPERIDINE N-(4-PHENYLAMINO-QUINAZOLIN-6-YL)-ACRYLAMIDE (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide Ponatinib
BCR and PTPN11	breakpoint cluster region	protein tyrosine phosphatase, non-receptor type 11	Rho GTPase cycle Signaling by FGFR in disease Signaling by Rho GTPases Signaling by FGFR1 mutants Signaling by FGFR mutants Signaling by FGFR1 fusion mutants	Signaling by FGFR in disease Netrin mediated repulsion signals Signaling by EGFRvIII in Cancer Interferon gamma signaling Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Prolactin receptor signaling SHC-mediated signalling PI3K Cascade TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation Spry regulation of FGF signaling Constitutive PI3K/AKT Signaling in Cancer Platelet sensitization by LDL Signaling by VEGF Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction Interleukin-2 signaling PI3K/AKT Signaling in Cancer Frs2-mediated activation Adaptive Immune System Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation PI3K events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Netrin-1 signaling RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade Interferon Signaling CTLA4 inhibitory signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Tie2 Signaling PECAM1 interactions Signaling by FGFR ARMS-mediated activation Nuclear signaling by ERBB4 Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PD-1 signaling PI3K Cascade Signaling by the B Cell Receptor (BCR) Signaling by GPCR FCERI mediated MAPK activation Signaling by SCF-KIT SHC1 events in ERBB2 signaling DAP12 signaling PI-3K cascade Toll Like Receptor 9 (TLR9) Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions Regulation of IFNA signaling GAB1 signalosome GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Signal regulatory protein (SIRP) family interactions Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Platelet homeostasis Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Costimulation by the CD28 family ERK activation PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Interferon alpha/beta signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell surface interactions at the vascular wall ERK2 activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade ERK2 activation Regulation of IFNG signaling		Dodecane-Trimethylamine
BCR and IGSF21	breakpoint cluster region	immunoglobin superfamily, member 21	Rho GTPase cycle Signaling by FGFR in disease Signaling by Rho GTPases Signaling by FGFR1 mutants Signaling by FGFR mutants Signaling by FGFR1 fusion mutants
BCR and IRS1	breakpoint cluster region	insulin receptor substrate 1	Rho GTPase cycle Signaling by FGFR in disease Signaling by Rho GTPases Signaling by FGFR1 mutants Signaling by FGFR mutants Signaling by FGFR1 fusion mutants	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade SOS-mediated signalling PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Signaling by Leptin Growth hormone receptor signaling Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS activation PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling Signal attenuation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade		[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID
BDKRB2 and PTPN11	bradykinin receptor B2	protein tyrosine phosphatase, non-receptor type 11	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Signaling by FGFR in disease Netrin mediated repulsion signals Signaling by EGFRvIII in Cancer Interferon gamma signaling Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Prolactin receptor signaling SHC-mediated signalling PI3K Cascade TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation Spry regulation of FGF signaling Constitutive PI3K/AKT Signaling in Cancer Platelet sensitization by LDL Signaling by VEGF Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction Interleukin-2 signaling PI3K/AKT Signaling in Cancer Frs2-mediated activation Adaptive Immune System Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation PI3K events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Netrin-1 signaling RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade Interferon Signaling CTLA4 inhibitory signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Tie2 Signaling PECAM1 interactions Signaling by FGFR ARMS-mediated activation Nuclear signaling by ERBB4 Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PD-1 signaling PI3K Cascade Signaling by the B Cell Receptor (BCR) Signaling by GPCR FCERI mediated MAPK activation Signaling by SCF-KIT SHC1 events in ERBB2 signaling DAP12 signaling PI-3K cascade Toll Like Receptor 9 (TLR9) Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions Regulation of IFNA signaling GAB1 signalosome GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Signal regulatory protein (SIRP) family interactions Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Platelet homeostasis Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Costimulation by the CD28 family ERK activation PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Interferon alpha/beta signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell surface interactions at the vascular wall ERK2 activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade ERK2 activation Regulation of IFNG signaling		Dodecane-Trimethylamine
BDKRB2 and GRK5	bradykinin receptor B2	G protein-coupled receptor kinase 5	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK

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