HIV - Wiki-Pi

Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 2 Hide
ARF1 and EEF1G	ADP-ribosylation factor 1	eukaryotic translation elongation factor 1 gamma	Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Golgi Associated Vesicle Biogenesis Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Golgi to ER Retrograde Transport MHC class II antigen presentation COPI Mediated Transport Phospholipid metabolism trans-Golgi Network Vesicle Budding Nef Mediated CD4 Down-regulation Adaptive Immune System PI Metabolism	Translation Eukaryotic Translation Elongation
ARF1 and ASAP2	ADP-ribosylation factor 1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Golgi Associated Vesicle Biogenesis Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Golgi to ER Retrograde Transport MHC class II antigen presentation COPI Mediated Transport Phospholipid metabolism trans-Golgi Network Vesicle Budding Nef Mediated CD4 Down-regulation Adaptive Immune System PI Metabolism
ARF1 and GGA2	ADP-ribosylation factor 1	golgi-associated, gamma adaptin ear containing, ARF binding protein 2	Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Golgi Associated Vesicle Biogenesis Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Golgi to ER Retrograde Transport MHC class II antigen presentation COPI Mediated Transport Phospholipid metabolism trans-Golgi Network Vesicle Budding Nef Mediated CD4 Down-regulation Adaptive Immune System PI Metabolism
ARF1 and COPB1	ADP-ribosylation factor 1	coatomer protein complex, subunit beta 1	Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Golgi Associated Vesicle Biogenesis Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Golgi to ER Retrograde Transport MHC class II antigen presentation COPI Mediated Transport Phospholipid metabolism trans-Golgi Network Vesicle Budding Nef Mediated CD4 Down-regulation Adaptive Immune System PI Metabolism	COPI Mediated Transport Golgi to ER Retrograde Transport
ARF1 and COPG1	ADP-ribosylation factor 1	coatomer protein complex, subunit gamma 1	Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Golgi Associated Vesicle Biogenesis Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Golgi to ER Retrograde Transport MHC class II antigen presentation COPI Mediated Transport Phospholipid metabolism trans-Golgi Network Vesicle Budding Nef Mediated CD4 Down-regulation Adaptive Immune System PI Metabolism	COPI Mediated Transport Golgi to ER Retrograde Transport	S-(Dimethylarsenic)Cysteine
ARF1 and ASAP1	ADP-ribosylation factor 1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Golgi Associated Vesicle Biogenesis Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Golgi to ER Retrograde Transport MHC class II antigen presentation COPI Mediated Transport Phospholipid metabolism trans-Golgi Network Vesicle Budding Nef Mediated CD4 Down-regulation Adaptive Immune System PI Metabolism	Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance VxPx cargo-targeting to cilium Assembly of the primary cilium
ARF1 and NOA1	ADP-ribosylation factor 1	nitric oxide associated 1	Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Golgi Associated Vesicle Biogenesis Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Golgi to ER Retrograde Transport MHC class II antigen presentation COPI Mediated Transport Phospholipid metabolism trans-Golgi Network Vesicle Budding Nef Mediated CD4 Down-regulation Adaptive Immune System PI Metabolism
ARF1 and CYTH2	ADP-ribosylation factor 1	cytohesin 2	Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Golgi Associated Vesicle Biogenesis Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Golgi to ER Retrograde Transport MHC class II antigen presentation COPI Mediated Transport Phospholipid metabolism trans-Golgi Network Vesicle Budding Nef Mediated CD4 Down-regulation Adaptive Immune System PI Metabolism
ARF1 and CYTH1	ADP-ribosylation factor 1	cytohesin 1	Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Golgi Associated Vesicle Biogenesis Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Golgi to ER Retrograde Transport MHC class II antigen presentation COPI Mediated Transport Phospholipid metabolism trans-Golgi Network Vesicle Budding Nef Mediated CD4 Down-regulation Adaptive Immune System PI Metabolism
ARF1 and COPE	ADP-ribosylation factor 1	coatomer protein complex, subunit epsilon	Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Golgi Associated Vesicle Biogenesis Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Golgi to ER Retrograde Transport MHC class II antigen presentation COPI Mediated Transport Phospholipid metabolism trans-Golgi Network Vesicle Budding Nef Mediated CD4 Down-regulation Adaptive Immune System PI Metabolism	COPI Mediated Transport Golgi to ER Retrograde Transport
ARF1 and ARFGAP1	ADP-ribosylation factor 1	ADP-ribosylation factor GTPase activating protein 1	Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Golgi Associated Vesicle Biogenesis Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Golgi to ER Retrograde Transport MHC class II antigen presentation COPI Mediated Transport Phospholipid metabolism trans-Golgi Network Vesicle Budding Nef Mediated CD4 Down-regulation Adaptive Immune System PI Metabolism	IRE1alpha activates chaperones COPI Mediated Transport XBP1(S) activates chaperone genes Golgi to ER Retrograde Transport Unfolded Protein Response (UPR)
ARF1 and INSR	ADP-ribosylation factor 1	insulin receptor	Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Golgi Associated Vesicle Biogenesis Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Golgi to ER Retrograde Transport MHC class II antigen presentation COPI Mediated Transport Phospholipid metabolism trans-Golgi Network Vesicle Budding Nef Mediated CD4 Down-regulation Adaptive Immune System PI Metabolism	Insulin receptor signalling cascade IRS activation Signal attenuation IRS-related events SHC-related events Insulin receptor recycling SHC activation Signaling by Insulin receptor	Insulin Regular Insulin Lispro Insulin Glargine Insulin, porcine Mecasermin Insulin Aspart Insulin Detemir Insulin Glulisine Adenosine-5\'-[Beta, Gamma-Methylene]Triphosphate [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID Insulin, isophane
ARF1 and TMED10	ADP-ribosylation factor 1	transmembrane emp24-like trafficking protein 10 (yeast)	Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Golgi Associated Vesicle Biogenesis Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Golgi to ER Retrograde Transport MHC class II antigen presentation COPI Mediated Transport Phospholipid metabolism trans-Golgi Network Vesicle Budding Nef Mediated CD4 Down-regulation Adaptive Immune System PI Metabolism
ARF1 and KDELR1	ADP-ribosylation factor 1	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1	Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Golgi Associated Vesicle Biogenesis Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Golgi to ER Retrograde Transport MHC class II antigen presentation COPI Mediated Transport Phospholipid metabolism trans-Golgi Network Vesicle Budding Nef Mediated CD4 Down-regulation Adaptive Immune System PI Metabolism
ARF1 and PIP5K1A	ADP-ribosylation factor 1	phosphatidylinositol-4-phosphate 5-kinase, type I, alpha	Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Golgi Associated Vesicle Biogenesis Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Golgi to ER Retrograde Transport MHC class II antigen presentation COPI Mediated Transport Phospholipid metabolism trans-Golgi Network Vesicle Budding Nef Mediated CD4 Down-regulation Adaptive Immune System PI Metabolism	Synthesis of PIPs at the plasma membrane Metabolism of lipids and lipoproteins Phospholipid metabolism PI Metabolism
ARF1 and PICK1	ADP-ribosylation factor 1	protein interacting with PRKCA 1	Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Golgi Associated Vesicle Biogenesis Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Golgi to ER Retrograde Transport MHC class II antigen presentation COPI Mediated Transport Phospholipid metabolism trans-Golgi Network Vesicle Budding Nef Mediated CD4 Down-regulation Adaptive Immune System PI Metabolism	Trafficking of GluR2-containing AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses
ARF1 and MDM4	ADP-ribosylation factor 1	MDM4, p53 regulator	Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Golgi Associated Vesicle Biogenesis Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Golgi to ER Retrograde Transport MHC class II antigen presentation COPI Mediated Transport Phospholipid metabolism trans-Golgi Network Vesicle Budding Nef Mediated CD4 Down-regulation Adaptive Immune System PI Metabolism
ARF1 and TMED2	ADP-ribosylation factor 1	transmembrane emp24 domain trafficking protein 2	Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Golgi Associated Vesicle Biogenesis Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Golgi to ER Retrograde Transport MHC class II antigen presentation COPI Mediated Transport Phospholipid metabolism trans-Golgi Network Vesicle Budding Nef Mediated CD4 Down-regulation Adaptive Immune System PI Metabolism	Pre-NOTCH Processing in Golgi Signaling by NOTCH Pre-NOTCH Expression and Processing
ARF1 and PLD1	ADP-ribosylation factor 1	phospholipase D1, phosphatidylcholine-specific	Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Golgi Associated Vesicle Biogenesis Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Golgi to ER Retrograde Transport MHC class II antigen presentation COPI Mediated Transport Phospholipid metabolism trans-Golgi Network Vesicle Budding Nef Mediated CD4 Down-regulation Adaptive Immune System PI Metabolism	Synthesis of PA Metabolism of lipids and lipoproteins Synthesis of PG Role of phospholipids in phagocytosis Phospholipid metabolism Glycerophospholipid biosynthesis Fcgamma receptor (FCGR) dependent phagocytosis Innate Immune System
ARF1 and PLD2	ADP-ribosylation factor 1	phospholipase D2	Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Golgi Associated Vesicle Biogenesis Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Golgi to ER Retrograde Transport MHC class II antigen presentation COPI Mediated Transport Phospholipid metabolism trans-Golgi Network Vesicle Budding Nef Mediated CD4 Down-regulation Adaptive Immune System PI Metabolism	Synthesis of PA Metabolism of lipids and lipoproteins Synthesis of PG Role of phospholipids in phagocytosis Phospholipid metabolism Glycerophospholipid biosynthesis Fcgamma receptor (FCGR) dependent phagocytosis Innate Immune System

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