| MFNG and NOTCH2 |
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
notch 2 |
- Pre-NOTCH Processing in Golgi
- Signaling by NOTCH
- Pre-NOTCH Expression and Processing
|
- Notch-HLH transcription pathway
- Signaling by NOTCH2
- Generic Transcription Pathway
- Pre-NOTCH Processing in Golgi
- Pre-NOTCH Transcription and Translation
- Signaling by NOTCH
- Pre-NOTCH Processing in the Endoplasmic Reticulum
- Pre-NOTCH Expression and Processing
- NOTCH2 intracellular domain regulates transcription
- NOTCH2 Activation and Transmission of Signal to the Nucleus
|
|
|
|
|
| MSN and PRKCQ |
moesin |
protein kinase C, theta |
- Axon guidance
- L1CAM interactions
- Recycling pathway of L1
|
- G alpha (q) signalling events
- Signaling by GPCR
- Downstream TCR signaling
- Axon guidance
- Effects of PIP2 hydrolysis
- FCERI mediated NF-kB activation
- Inactivation, recovery and regulation of the phototransduction cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- The phototransduction cascade
- Programmed Cell Death
- G alpha (z) signalling events
- Netrin-1 signaling
- Innate Immune System
- Apoptotic cleavage of cellular proteins
- Apoptotic execution phase
- Diseases associated with visual transduction
- G alpha (q) signalling events
- GPCR downstream signaling
- TCR signaling
- Visual phototransduction
- Fc epsilon receptor (FCERI) signaling
- Platelet activation, signaling and aggregation
- Adaptive Immune System
|
|
- Staurosporine
- Phosphonothreonine
- Phosphonoserine
|
|
|
| MSX2 and PPARG |
msh homeobox 2 |
peroxisome proliferator-activated receptor gamma |
|
- PPARA activates gene expression
- Fatty acid, triacylglycerol, and ketone body metabolism
- Metabolism of lipids and lipoproteins
- Generic Transcription Pathway
- Transcriptional regulation of white adipocyte differentiation
- Nuclear Receptor transcription pathway
- Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
|
|
- Icosapent
- Troglitazone
- Mesalazine
- Indomethacin
- Rosiglitazone
- Nateglinide
- Sulfasalazine
- Repaglinide
- Telmisartan
- Balsalazide
- Ibuprofen
- Glipizide
- Pioglitazone
- Mitiglinide
- Bezafibrate
- (S)-3-(4-(2-Carbazol-9-Yl-Ethoxy)-Phenyl)-2-Ethoxy-Propionic Acid
- 2-{5-[3-(6-BENZOYL-1-PROPYLNAPHTHALEN-2-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID
- (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID
- (9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acid
- 2-{5-[3-(7-PROPYL-3-TRIFLUOROMETHYLBENZO[D]ISOXAZOL-6-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID
- (4S,5E,7Z,10Z,13Z,16Z,19Z)-4-hydroxydocosa-5,7,10,13,16,19-hexaenoic acid
- (5R,6E,8Z,11Z,14Z,17Z)-5-hydroxyicosa-6,8,11,14,17-pentaenoic acid
- (8E,10S,12Z)-10-hydroxy-6-oxooctadeca-8,12-dienoic acid
- (8R,9Z,12Z)-8-hydroxy-6-oxooctadeca-9,12-dienoic acid
- (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid
- difluoro(5-{2-[(5-octyl-1H-pyrrol-2-yl-kappaN)methylidene]-2H-pyrrol-5-yl-kappaN}pentanoato)boron
- (2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACID
- 3-(5-methoxy-1H-indol-3-yl)propanoic acid
- 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid
- (2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid
- 2-chloro-5-nitro-N-phenylbenzamide
- (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid
- 3-[5-(2-nitropent-1-en-1-yl)furan-2-yl]benzoic acid
- 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID
- (5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid
- 3-FLUORO-N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]BENZENESULFONAMIDE
- (2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid
- ALEGLITAZAR
|
|
|
| MTNR1A and MTNR1B |
melatonin receptor 1A |
melatonin receptor 1B |
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- GPCR downstream signaling
- Class A/1 (Rhodopsin-like receptors)
- G alpha (i) signalling events
- Metabolic disorders of biological oxidation enzymes
- GPCR ligand binding
|
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- GPCR downstream signaling
- Class A/1 (Rhodopsin-like receptors)
- G alpha (i) signalling events
- Metabolic disorders of biological oxidation enzymes
- GPCR ligand binding
|
- Ramelteon
- Melatonin
- Agomelatine
|
- Ramelteon
- Melatonin
- Agomelatine
|
|
|
| MTNR1B and GPR50 |
melatonin receptor 1B |
G protein-coupled receptor 50 |
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- GPCR downstream signaling
- Class A/1 (Rhodopsin-like receptors)
- G alpha (i) signalling events
- Metabolic disorders of biological oxidation enzymes
- GPCR ligand binding
|
|
- Ramelteon
- Melatonin
- Agomelatine
|
|
|
|
| MTNR1B and HNRNPA0 |
melatonin receptor 1B |
heterogeneous nuclear ribonucleoprotein A0 |
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- GPCR downstream signaling
- Class A/1 (Rhodopsin-like receptors)
- G alpha (i) signalling events
- Metabolic disorders of biological oxidation enzymes
- GPCR ligand binding
|
- Processing of Capped Intron-Containing Pre-mRNA
- mRNA Splicing
- mRNA Splicing - Major Pathway
|
- Ramelteon
- Melatonin
- Agomelatine
|
|
|
|
| MTNR1B and PI4KA |
melatonin receptor 1B |
phosphatidylinositol 4-kinase, catalytic, alpha |
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- GPCR downstream signaling
- Class A/1 (Rhodopsin-like receptors)
- G alpha (i) signalling events
- Metabolic disorders of biological oxidation enzymes
- GPCR ligand binding
|
- Synthesis of PIPs at the Golgi membrane
- Metabolism of lipids and lipoproteins
- Synthesis of PIPs at the ER membrane
- Phospholipid metabolism
- PI Metabolism
|
- Ramelteon
- Melatonin
- Agomelatine
|
|
|
|
| MTNR1B and ITM2C |
melatonin receptor 1B |
integral membrane protein 2C |
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- GPCR downstream signaling
- Class A/1 (Rhodopsin-like receptors)
- G alpha (i) signalling events
- Metabolic disorders of biological oxidation enzymes
- GPCR ligand binding
|
|
- Ramelteon
- Melatonin
- Agomelatine
|
|
|
|
| MTNR1B and GNB4 |
melatonin receptor 1B |
guanine nucleotide binding protein (G protein), beta polypeptide 4 |
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- GPCR downstream signaling
- Class A/1 (Rhodopsin-like receptors)
- G alpha (i) signalling events
- Metabolic disorders of biological oxidation enzymes
- GPCR ligand binding
|
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- G alpha (q) signalling events
- Signaling by GPCR
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- ADP signalling through P2Y purinoceptor 1
- Integration of energy metabolism
- G alpha (s) signalling events
- Glucagon-type ligand receptors
- Signal amplification
- Signaling by Wnt
- G beta:gamma signalling through PLC beta
- Metabolic disorders of biological oxidation enzymes
- G beta:gamma signalling through PI3Kgamma
- Gastrin-CREB signalling pathway via PKC and MAPK
- Thromboxane signalling through TP receptor
- G alpha (z) signalling events
- G alpha (12/13) signalling events
- G alpha (i) signalling events
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Class B/2 (Secretin family receptors)
- ADP signalling through P2Y purinoceptor 12
- Glucagon signaling in metabolic regulation
- Prostacyclin signalling through prostacyclin receptor
- G-protein beta:gamma signalling
- Vasopressin regulates renal water homeostasis via Aquaporins
- Opioid Signalling
- Regulation of insulin secretion
- Activation of Kainate Receptors upon glutamate binding
- Aquaporin-mediated transport
- GPCR ligand binding
- beta-catenin independent WNT signaling
- Adrenaline,noradrenaline inhibits insulin secretion
- G alpha (q) signalling events
- Thrombin signalling through proteinase activated receptors (PARs)
- Presynaptic function of Kainate receptors
- GPCR downstream signaling
- Platelet homeostasis
- Ca2+ pathway
- G-protein activation
- Platelet activation, signaling and aggregation
- Transmission across Chemical Synapses
|
- Ramelteon
- Melatonin
- Agomelatine
|
|
|
|
| MTNR1B and PDIA6 |
melatonin receptor 1B |
protein disulfide isomerase family A, member 6 |
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- GPCR downstream signaling
- Class A/1 (Rhodopsin-like receptors)
- G alpha (i) signalling events
- Metabolic disorders of biological oxidation enzymes
- GPCR ligand binding
|
- IRE1alpha activates chaperones
- XBP1(S) activates chaperone genes
- Unfolded Protein Response (UPR)
|
- Ramelteon
- Melatonin
- Agomelatine
|
|
|
|
| MTNR1B and IRS4 |
melatonin receptor 1B |
insulin receptor substrate 4 |
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- GPCR downstream signaling
- Class A/1 (Rhodopsin-like receptors)
- G alpha (i) signalling events
- Metabolic disorders of biological oxidation enzymes
- GPCR ligand binding
|
- IRS-related events triggered by IGF1R
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- IGF1R signaling cascade
|
- Ramelteon
- Melatonin
- Agomelatine
|
|
|
|
| MTNR1B and PPM1G |
melatonin receptor 1B |
protein phosphatase, Mg2+/Mn2+ dependent, 1G |
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- GPCR downstream signaling
- Class A/1 (Rhodopsin-like receptors)
- G alpha (i) signalling events
- Metabolic disorders of biological oxidation enzymes
- GPCR ligand binding
|
|
- Ramelteon
- Melatonin
- Agomelatine
|
|
|
|
| MTNR1B and VPS35 |
melatonin receptor 1B |
vacuolar protein sorting 35 homolog (S. cerevisiae) |
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- GPCR downstream signaling
- Class A/1 (Rhodopsin-like receptors)
- G alpha (i) signalling events
- Metabolic disorders of biological oxidation enzymes
- GPCR ligand binding
|
- WNT ligand secretion is abrogated by the PORCN inhibitor LGK974
- Signaling by Wnt
- Signaling by WNT in cancer
- WNT ligand biogenesis and trafficking
|
- Ramelteon
- Melatonin
- Agomelatine
|
|
|
|
| MTNR1B and YWHAQ |
melatonin receptor 1B |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta |
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- GPCR downstream signaling
- Class A/1 (Rhodopsin-like receptors)
- G alpha (i) signalling events
- Metabolic disorders of biological oxidation enzymes
- GPCR ligand binding
|
- Activation of BAD and translocation to mitochondria
- Programmed Cell Death
- Translocation of GLUT4 to the plasma membrane
- Activation of BH3-only proteins
- Intrinsic Pathway for Apoptosis
|
- Ramelteon
- Melatonin
- Agomelatine
|
|
|
|
| MUC1 and PPARG |
mucin 1, cell surface associated |
peroxisome proliferator-activated receptor gamma |
- Post-translational protein modification
- Termination of O-glycan biosynthesis
- O-linked glycosylation of mucins
- O-linked glycosylation
|
- PPARA activates gene expression
- Fatty acid, triacylglycerol, and ketone body metabolism
- Metabolism of lipids and lipoproteins
- Generic Transcription Pathway
- Transcriptional regulation of white adipocyte differentiation
- Nuclear Receptor transcription pathway
- Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
|
|
- Icosapent
- Troglitazone
- Mesalazine
- Indomethacin
- Rosiglitazone
- Nateglinide
- Sulfasalazine
- Repaglinide
- Telmisartan
- Balsalazide
- Ibuprofen
- Glipizide
- Pioglitazone
- Mitiglinide
- Bezafibrate
- (S)-3-(4-(2-Carbazol-9-Yl-Ethoxy)-Phenyl)-2-Ethoxy-Propionic Acid
- 2-{5-[3-(6-BENZOYL-1-PROPYLNAPHTHALEN-2-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID
- (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID
- (9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acid
- 2-{5-[3-(7-PROPYL-3-TRIFLUOROMETHYLBENZO[D]ISOXAZOL-6-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID
- (4S,5E,7Z,10Z,13Z,16Z,19Z)-4-hydroxydocosa-5,7,10,13,16,19-hexaenoic acid
- (5R,6E,8Z,11Z,14Z,17Z)-5-hydroxyicosa-6,8,11,14,17-pentaenoic acid
- (8E,10S,12Z)-10-hydroxy-6-oxooctadeca-8,12-dienoic acid
- (8R,9Z,12Z)-8-hydroxy-6-oxooctadeca-9,12-dienoic acid
- (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid
- difluoro(5-{2-[(5-octyl-1H-pyrrol-2-yl-kappaN)methylidene]-2H-pyrrol-5-yl-kappaN}pentanoato)boron
- (2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACID
- 3-(5-methoxy-1H-indol-3-yl)propanoic acid
- 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid
- (2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid
- 2-chloro-5-nitro-N-phenylbenzamide
- (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid
- 3-[5-(2-nitropent-1-en-1-yl)furan-2-yl]benzoic acid
- 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID
- (5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid
- 3-FLUORO-N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]BENZENESULFONAMIDE
- (2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid
- ALEGLITAZAR
|
|
|
| GADD45B and PPARG |
growth arrest and DNA-damage-inducible, beta |
peroxisome proliferator-activated receptor gamma |
|
- PPARA activates gene expression
- Fatty acid, triacylglycerol, and ketone body metabolism
- Metabolism of lipids and lipoproteins
- Generic Transcription Pathway
- Transcriptional regulation of white adipocyte differentiation
- Nuclear Receptor transcription pathway
- Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
|
|
- Icosapent
- Troglitazone
- Mesalazine
- Indomethacin
- Rosiglitazone
- Nateglinide
- Sulfasalazine
- Repaglinide
- Telmisartan
- Balsalazide
- Ibuprofen
- Glipizide
- Pioglitazone
- Mitiglinide
- Bezafibrate
- (S)-3-(4-(2-Carbazol-9-Yl-Ethoxy)-Phenyl)-2-Ethoxy-Propionic Acid
- 2-{5-[3-(6-BENZOYL-1-PROPYLNAPHTHALEN-2-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID
- (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID
- (9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acid
- 2-{5-[3-(7-PROPYL-3-TRIFLUOROMETHYLBENZO[D]ISOXAZOL-6-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID
- (4S,5E,7Z,10Z,13Z,16Z,19Z)-4-hydroxydocosa-5,7,10,13,16,19-hexaenoic acid
- (5R,6E,8Z,11Z,14Z,17Z)-5-hydroxyicosa-6,8,11,14,17-pentaenoic acid
- (8E,10S,12Z)-10-hydroxy-6-oxooctadeca-8,12-dienoic acid
- (8R,9Z,12Z)-8-hydroxy-6-oxooctadeca-9,12-dienoic acid
- (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid
- difluoro(5-{2-[(5-octyl-1H-pyrrol-2-yl-kappaN)methylidene]-2H-pyrrol-5-yl-kappaN}pentanoato)boron
- (2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACID
- 3-(5-methoxy-1H-indol-3-yl)propanoic acid
- 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid
- (2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid
- 2-chloro-5-nitro-N-phenylbenzamide
- (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid
- 3-[5-(2-nitropent-1-en-1-yl)furan-2-yl]benzoic acid
- 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID
- (5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid
- 3-FLUORO-N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]BENZENESULFONAMIDE
- (2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid
- ALEGLITAZAR
|
|
|
| MYOC and NOTCH2 |
myocilin, trabecular meshwork inducible glucocorticoid response |
notch 2 |
|
- Notch-HLH transcription pathway
- Signaling by NOTCH2
- Generic Transcription Pathway
- Pre-NOTCH Processing in Golgi
- Pre-NOTCH Transcription and Translation
- Signaling by NOTCH
- Pre-NOTCH Processing in the Endoplasmic Reticulum
- Pre-NOTCH Expression and Processing
- NOTCH2 intracellular domain regulates transcription
- NOTCH2 Activation and Transmission of Signal to the Nucleus
|
|
|
|
|
| NEUROD1 and TCF4 |
neuronal differentiation 1 |
transcription factor 4 |
- Regulation of beta-cell development
- Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
- Regulation of gene expression in beta cells
|
- CDO in myogenesis
- Myogenesis
|
|
|
|
|
| NFE2L1 and BACH2 |
nuclear factor, erythroid 2-like 1 |
BTB and CNC homology 1, basic leucine zipper transcription factor 2 |
|
|
|
|
|
|
| NFE2L2 and PRKCQ |
nuclear factor, erythroid 2-like 2 |
protein kinase C, theta |
|
- G alpha (q) signalling events
- Signaling by GPCR
- Downstream TCR signaling
- Axon guidance
- Effects of PIP2 hydrolysis
- FCERI mediated NF-kB activation
- Inactivation, recovery and regulation of the phototransduction cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- The phototransduction cascade
- Programmed Cell Death
- G alpha (z) signalling events
- Netrin-1 signaling
- Innate Immune System
- Apoptotic cleavage of cellular proteins
- Apoptotic execution phase
- Diseases associated with visual transduction
- G alpha (q) signalling events
- GPCR downstream signaling
- TCR signaling
- Visual phototransduction
- Fc epsilon receptor (FCERI) signaling
- Platelet activation, signaling and aggregation
- Adaptive Immune System
|
|
- Staurosporine
- Phosphonothreonine
- Phosphonoserine
|
|
|