PUM3 and AK3

		PUM3	AK3
Description		pumilio RNA binding family member 3	adenylate kinase 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Endoplasmic Reticulum	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	DNA Binding RNA Binding MRNA Binding Protein Binding	Nucleotide Binding AMP Kinase Activity Protein Binding ATP Binding GTP Binding Kinase Activity Transferase Activity Phosphotransferase Activity, Phosphate Group As Acceptor Ligase Activity Nucleobase-containing Compound Kinase Activity Nucleoside Triphosphate Adenylate Kinase Activity
	Biological Process	Regulation Of Translation Regulation Of Protein ADP-ribosylation	Nucleobase-containing Compound Metabolic Process ADP Biosynthetic Process Blood Coagulation Nucleotide Metabolic Process Nucleoside Monophosphate Metabolic Process Nucleoside Triphosphate Biosynthetic Process AMP Metabolic Process GTP Metabolic Process ITP Metabolic Process UTP Metabolic Process
Pathways			Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Depression ( 29700475) Smoking initiation ( 33082346) Waist circumference adjusted for body mass index ( 28552196)	Crohn's disease ( 22412388) Hematological parameters ( 19820697) Mean corpuscular hemoglobin ( 27863252) Mean spheric corpuscular volume ( 32888494) Platelet count ( 20139978 22139419 26805783 29403010) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189) White blood cell count ( 27863252)
Interacting Genes		5 interacting genes: APP CALM1 CEBPA HPS6 ITGB1BP2	6 interacting genes: APPBP2 DAPK3 FBLN1 KRTAP10-8 TRIM54 ZDHHC17
Entrez ID		9933	50808
HPRD ID		08822	12439
Ensembl ID		ENSG00000080608	ENSG00000147853
Uniprot IDs		Q15397	Q7Z4Y4 Q9UIJ7
PDB IDs		4WZR 4WZW	1ZD8 6ZJB 6ZJD 6ZJE
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Dendritic Shaft Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Response To Metal Ion Chemical Homeostasis Intermediate-density Lipoprotein Particle Regulation Of Monoatomic Ion Transport Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Intracellular Signaling Cassette Regulation Of Membrane Potential Trans-Golgi Network Membrane Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Early Endosome Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Response To Peptide Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Synaptic Transmission Response To Cytokine Regulation Of Inflammatory Response Regulation Of Calcium-mediated Signaling Regulation Of Calcium Ion Transport Regulation Of Metal Ion Transport Protein Heterodimerization Activity Lipoprotein Particle Memory Growth Factor Receptor Binding Main Axon Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of Monoatomic Cation Transmembrane Transport
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