TOMM70 and NIT2

		TOMM70	NIT2
Description		translocase of outer mitochondrial membrane 70	nitrilase family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Membrane Mitochondrial Membrane Extracellular Exosome TOM Complex	Extracellular Region Cytoplasm Mitochondrion Centrosome Cytosol Specific Granule Lumen Extracellular Exosome Tertiary Granule Lumen
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity Mitochondrion Targeting Sequence Binding Molecular Adaptor Activity	Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Omega-amidase Activity 2-oxoglutaramate Amidase Activity
	Biological Process	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Protein Targeting To Mitochondrion MRNA Transcription Protein Import Into Mitochondrial Matrix Positive Regulation Of Interferon-beta Production Regulation Of Apoptotic Process Protein Insertion Into Mitochondrial Inner Membrane Protein Insertion Into Mitochondrial Outer Membrane Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Response To Thyroxine Cellular Response To Virus Antiviral Innate Immune Response Positive Regulation Of Protein Targeting To Mitochondrion	Oxaloacetate Metabolic Process Asparagine Metabolic Process Glutamine Metabolic Process
Pathways		Mitochondrial protein import DDX58/IFIH1-mediated induction of interferon-alpha/beta PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses	Neutrophil degranulation
Drugs
Diseases
GWAS			Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Refractive error ( 32231278)
Interacting Genes		9 interacting genes: HSP90AA1 HSPA1A HSPA1B HSPB1 IRF3 OGT PINK1 PRKN SNAPIN	1 interacting genes: CFTR
Entrez ID		9868	56954
HPRD ID		16194	17634
Ensembl ID		ENSG00000154174	ENSG00000114021
Uniprot IDs		O94826	Q9NQR4 V9HW91
PDB IDs		7DHG 7KDT
Enriched GO Terms of Interacting Partners?		C3HC4-type RING Finger Domain Binding Protein Refolding Regulation Of Protein Ubiquitination Lysosomal Transport Regulation Of Post-translational Protein Modification Protein Folding Chaperone Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Vacuolar Transport Positive Regulation Of Gene Expression Positive Regulation Of Protein Polymerization Regulation Of Proteasomal Protein Catabolic Process Intracellular Transport Response To Unfolded Protein Response To Heat Regulation Of Protein Catabolic Process Regulation Of Protein Modification Process Mitochondrion To Lysosome Vesicle-mediated Transport Cellular Response To Hydrogen Sulfide Negative Regulation Of Apoptotic Signaling Pathway Protein Stabilization Negative Regulation Of Cellular Component Organization Aggresome Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Unfolded Protein Binding Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Hydrogen Sulfide ATP-dependent Protein Folding Chaperone Mitochondrial Transport Regulation Of Programmed Cell Death Histone Deacetylase Binding Negative Regulation Of Mitochondrial Fission Regulation Of Synaptic Vesicle Transport Cellular Localization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Establishment Of Localization In Cell Ubiquitin Protein Ligase Binding ATP-dependent Protein Disaggregase Activity Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Heat Acclimation Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Lewy Body Response To Temperature Stimulus Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Heat Cytosol Positive Regulation Of Microtubule Nucleation Mitophagy Regulation Of Ubiquitin-dependent Protein Catabolic Process	Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Response To Thyroxine TOM Complex Mitochondrion Targeting Sequence Binding Response To L-phenylalanine Derivative Bicarbonate Transmembrane Transporter Activity Regulation Of Establishment Of Protein Localization Intracellular PH Elevation Amelogenesis Mitochondrial Outer Membrane Translocase Complex ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Protein Insertion Into Mitochondrial Outer Membrane Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Golgi-associated Vesicle Membrane Cellular Response To Forskolin Response To Forskolin Protein Insertion Into Mitochondrial Inner Membrane Chloride Transmembrane Transporter Activity Sperm Capacitation Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Protein Localization Water Transport Bicarbonate Transport Protein Import Into Mitochondrial Matrix Response To Thyroid Hormone Negative Regulation Of Cardiac Muscle Tissue Growth Protein Transmembrane Transporter Activity Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity Vesicle Docking Involved In Exocytosis Multicellular Organismal-level Water Homeostasis Cholesterol Biosynthetic Process 14-3-3 Protein Binding Fluid Transport Positive Regulation Of Transporter Activity Transmembrane Transport
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?