NIT2

Description		nitrilase family member 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Centrosome Cytosol Specific Granule Lumen Extracellular Exosome Tertiary Granule Lumen
	Molecular Function	Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Omega-amidase Activity 2-oxoglutaramate Amidase Activity
	Biological Process	Oxaloacetate Metabolic Process Asparagine Metabolic Process Glutamine Metabolic Process
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS		Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Refractive error ( 32231278)
Novel Interacting Genes		1 novel interacting genes: TOMM70
Interacting Genes		1 interacting genes: CFTR
Entrez ID		56954
HPRD ID		17634
Ensembl ID		ENSG00000114021
Uniprot IDs		Q9NQR4 V9HW91
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Response To Thyroxine TOM Complex Mitochondrion Targeting Sequence Binding Response To L-phenylalanine Derivative Bicarbonate Transmembrane Transporter Activity Regulation Of Establishment Of Protein Localization Intracellular PH Elevation Amelogenesis Mitochondrial Outer Membrane Translocase Complex ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Protein Insertion Into Mitochondrial Outer Membrane Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Golgi-associated Vesicle Membrane Cellular Response To Forskolin Response To Forskolin Protein Insertion Into Mitochondrial Inner Membrane Chloride Transmembrane Transporter Activity Sperm Capacitation Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Protein Localization Water Transport Bicarbonate Transport Protein Import Into Mitochondrial Matrix Response To Thyroid Hormone Negative Regulation Of Cardiac Muscle Tissue Growth Protein Transmembrane Transporter Activity Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity Vesicle Docking Involved In Exocytosis Multicellular Organismal-level Water Homeostasis Cholesterol Biosynthetic Process 14-3-3 Protein Binding Fluid Transport Positive Regulation Of Transporter Activity Transmembrane Transport
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