TOMM70 and FOXC1

		TOMM70	FOXC1
Description		translocase of outer mitochondrial membrane 70	forkhead box C1
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Membrane Mitochondrial Membrane Extracellular Exosome TOM Complex	Chromatin Heterochromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity Mitochondrion Targeting Sequence Binding Molecular Adaptor Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding DNA Binding, Bending Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Promoter-specific Chromatin Binding
	Biological Process	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Protein Targeting To Mitochondrion MRNA Transcription Protein Import Into Mitochondrial Matrix Positive Regulation Of Interferon-beta Production Regulation Of Apoptotic Process Protein Insertion Into Mitochondrial Inner Membrane Protein Insertion Into Mitochondrial Outer Membrane Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Response To Thyroxine Cellular Response To Virus Antiviral Innate Immune Response Positive Regulation Of Protein Targeting To Mitochondrion	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ossification Angiogenesis Ovarian Follicle Development Blood Vessel Development Eye Development Ureteric Bud Development In Utero Embryonic Development Somitogenesis Kidney Development Lymph Vessel Development Endochondral Ossification Blood Vessel Remodeling Heart Morphogenesis Apoptotic Process Involved In Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Brain Development Heart Development Cell Population Proliferation Germ Cell Migration Anatomical Structure Morphogenesis Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Mesenchymal Cell Development Neural Crest Cell Development Cell Migration Negative Regulation Of Angiogenesis Cerebellum Development Cell Differentiation Collagen Fibril Organization Glycosaminoglycan Metabolic Process Lacrimal Gland Development Embryonic Heart Tube Development Maintenance Of Lens Transparency Vascular Endothelial Growth Factor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Camera-type Eye Development Positive Regulation Of DNA Binding Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of DNA-templated Transcription Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Organ Growth Vascular Endothelial Growth Factor Receptor Signaling Pathway Paraxial Mesoderm Formation Mesenchymal Cell Differentiation Artery Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Chemokine-mediated Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Glomerular Epithelium Development Blood Vessel Diameter Maintenance Negative Regulation Of Lymphangiogenesis Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis Positive Regulation Of Core Promoter Binding Cellular Response To Chemokine
Pathways		Mitochondrial protein import DDX58/IFIH1-mediated induction of interferon-alpha/beta PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses	Formation of intermediate mesoderm Formation of the ureteric bud
Drugs
Diseases			Axenfeld-Rieger syndrome (ARS)
GWAS			Coronary artery disease ( 29212778) Daytime sleep phenotypes ( 27126917) Essential hypertension (time to event) ( 32589924) Glaucoma ( 30054594 31959993) Glaucoma (high intraocular pressure) ( 26752265) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29891935 26752265) Heel bone mineral density ( 30598549) Intraocular pressure ( 29785010 30054594 31959993) Monobrow thickness ( 26926045) Non-response to citalopram or escitalopram and depression ( 27622933) Refractive error ( 32231278) Response to platinum-based agents ( 22020760) Systolic blood pressure ( 30224653)
Interacting Genes		9 interacting genes: HSP90AA1 HSPA1A HSPA1B HSPB1 IRF3 OGT PINK1 PRKN SNAPIN	2 interacting genes: HMGB1 NPHS2
Entrez ID		9868	2296
HPRD ID		16194	03054
Ensembl ID		ENSG00000154174	ENSG00000054598
Uniprot IDs		O94826	Q12948 W6CJ52
PDB IDs		7DHG 7KDT
Enriched GO Terms of Interacting Partners?		C3HC4-type RING Finger Domain Binding Protein Refolding Regulation Of Protein Ubiquitination Lysosomal Transport Regulation Of Post-translational Protein Modification Protein Folding Chaperone Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Vacuolar Transport Positive Regulation Of Gene Expression Positive Regulation Of Protein Polymerization Regulation Of Proteasomal Protein Catabolic Process Intracellular Transport Response To Unfolded Protein Response To Heat Regulation Of Protein Catabolic Process Regulation Of Protein Modification Process Mitochondrion To Lysosome Vesicle-mediated Transport Cellular Response To Hydrogen Sulfide Negative Regulation Of Apoptotic Signaling Pathway Protein Stabilization Negative Regulation Of Cellular Component Organization Aggresome Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Unfolded Protein Binding Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Hydrogen Sulfide ATP-dependent Protein Folding Chaperone Mitochondrial Transport Regulation Of Programmed Cell Death Histone Deacetylase Binding Negative Regulation Of Mitochondrial Fission Regulation Of Synaptic Vesicle Transport Cellular Localization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Establishment Of Localization In Cell Ubiquitin Protein Ligase Binding ATP-dependent Protein Disaggregase Activity Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Heat Acclimation Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Lewy Body Response To Temperature Stimulus Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Heat Cytosol Positive Regulation Of Microtubule Nucleation Mitophagy Regulation Of Ubiquitin-dependent Protein Catabolic Process	Positive Regulation Of Interferon-beta Production Regulation Of Interferon-beta Production Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Renal System Development Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Negative Regulation Of Apoptotic Cell Clearance Metanephric Podocyte Development C-X-C Chemokine Binding Alphav-beta3 Integrin-HMGB1 Complex T-helper 1 Cell Activation Positive Regulation Of Mismatch Repair Activation Of Innate Immune Response Regulation Of Mismatch Repair Negative Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Plasmacytoid Dendritic Cell Activation Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Innate Immune Response Myeloid Progenitor Cell Differentiation Negative Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Supercoiled DNA Binding Macromolecule Biosynthetic Process Positive Regulation Of Dendritic Cell Differentiation Regulation Of Endodeoxyribonuclease Activity Neutrophil Clearance Response To Thyroxine TOM Complex Mitochondrion Targeting Sequence Binding Response To L-phenylalanine Derivative DNA Geometric Change Regulation Of Glycogen Catabolic Process Bubble DNA Binding Slit Diaphragm Mitochondrial Outer Membrane Translocase Complex DNA-templated Transcription Regulation Of Apoptotic Cell Clearance Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production RAGE Receptor Binding Regulation Of Innate Immune Response Positive Regulation Of Defense Response Activation Of Immune Response Regulation Of Toll-like Receptor 9 Signaling Pathway DNA Topological Change
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