TMEM63A and DNAH14

		TMEM63A	DNAH14
Description		transmembrane protein 63A	dynein axonemal heavy chain 14
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Plasma Membrane Membrane Early Endosome Membrane Centriolar Satellite Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane	Cytoplasm Cytoskeleton Microtubule Cilium Dynein Complex Cell Projection 9+2 Motile Cilium
	Molecular Function	Nucleic Acid Binding Calcium-activated Cation Channel Activity Protein Binding Mechanosensitive Monoatomic Ion Channel Activity Phospholipid Scramblase Activity Osmolarity-sensing Monoatomic Cation Channel Activity	Nucleotide Binding ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding
	Biological Process	Monoatomic Ion Transport Lysosome Organization Monoatomic Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Surfactant Secretion	Microtubule-based Movement Cilium Movement Involved In Cell Motility
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS			Adult body size ( 32376654) Copper levels ( 26025379) Delirium ( 29631748) Feeling nervous ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota relative abundance (Bifidobacterium) ( 33208821) Heel bone mineral density x serum urate levels interaction ( 34046847) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377)
Interacting Genes		3 interacting genes: CCR2 DRD2 GPR37	2 interacting genes: APP FBXO7
Entrez ID		9725	127602
HPRD ID		13817	19478
Ensembl ID		ENSG00000196187	ENSG00000185842
Uniprot IDs		O94886	A0A804HLD3 M9MMK7 Q0VDD8
PDB IDs		8EHW 8GRS 8WUA
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity Catecholamine Metabolic Process Dopamine Metabolic Process Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Biogenic Amine Metabolic Process Dendrite Regulation Of Synaptic Transmission, Glutamatergic Phenol-containing Compound Metabolic Process Amine Metabolic Process Negative Regulation Of Secretion By Cell G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission Perikaryon Prosaposin Receptor Activity Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Chemokine (C-C Motif) Ligand 12 Binding Positive Regulation Of Thymocyte Migration Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 2 Binding Positive Regulation Of Hematopoietic Stem Cell Migration Regulation Of Astrocyte Chemotaxis Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Negative Regulation Of Secretion Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Intracellular Calcium Ion Homeostasis Negative Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Thymocyte Migration Regulation Of Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Dopamine Secretion Calcium Ion Homeostasis Response To Wounding Negative Regulation Of Immune Response CCR2 Chemokine Receptor Binding Positive Regulation Of T Cell Extravasation Dopamine Binding Dopamine Neurotransmitter Receptor Activity Cerebral Cortex GABAergic Interneuron Migration Dopamine Uptake Involved In Synaptic Transmission Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Dephosphorylation Beta-arrestin-dependent Dopamine Receptor Signaling Pathway	Amyloid-beta Complex Dendritic Shaft Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Cell Cycle G1/S Phase Transition Glial Cytoplasmic Inclusion Classical Lewy Body Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Lewy Body Corona Lewy Neurite Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Regulation Of Mitotic Cell Cycle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Surfactant Secretion Lewy Body Core Positive Regulation Of Mesoderm Development Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Osmolarity-sensing Monoatomic Cation Channel Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Hemopoiesis Regulation Of Toll Signaling Pathway
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