TMEM63A

Name	transmembrane protein 63A
Structure
Novel Interactors	1 novel interactors: DNAH14
Interactors	3 interactors: CCR2 DRD2 GPR37
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Plasma Membrane Membrane Early Endosome Membrane Centriolar Satellite Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	Nucleic Acid Binding Calcium-activated Cation Channel Activity Protein Binding Mechanosensitive Monoatomic Ion Channel Activity Phospholipid Scramblase Activity Osmolarity-sensing Monoatomic Cation Channel Activity
	Biological Process	Monoatomic Ion Transport Lysosome Organization Monoatomic Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Surfactant Secretion
Pathways	Neutrophil degranulation
GWAS	No GWAS studies recorded
Entrez ID	9725
HPRD ID	13817
Ensembl ID	ENSG00000196187
Uniprot IDs	O94886
PDB IDs	8EHW 8GRS 8WUA
GO Terms Enriched among Interactors ?	G Protein-coupled Receptor Activity Catecholamine Metabolic Process Dopamine Metabolic Process Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Biogenic Amine Metabolic Process Dendrite Regulation Of Synaptic Transmission, Glutamatergic Phenol-containing Compound Metabolic Process Amine Metabolic Process Negative Regulation Of Secretion By Cell G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission Perikaryon Prosaposin Receptor Activity Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Chemokine (C-C Motif) Ligand 12 Binding Positive Regulation Of Thymocyte Migration Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 2 Binding Positive Regulation Of Hematopoietic Stem Cell Migration Regulation Of Astrocyte Chemotaxis Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Negative Regulation Of Secretion Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Intracellular Calcium Ion Homeostasis Negative Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Thymocyte Migration Regulation Of Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Dopamine Secretion Calcium Ion Homeostasis Response To Wounding Negative Regulation Of Immune Response CCR2 Chemokine Receptor Binding Positive Regulation Of T Cell Extravasation Dopamine Binding Dopamine Neurotransmitter Receptor Activity Cerebral Cortex GABAergic Interneuron Migration Dopamine Uptake Involved In Synaptic Transmission Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Dephosphorylation Beta-arrestin-dependent Dopamine Receptor Signaling Pathway