TP53I3 and GPX3

Number of citations of the paper that reports this interaction (PubMedID 22461624)
33

		TP53I3	GPX3
Description		tumor protein p53 inducible protein 3	glutathione peroxidase 3
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GO Annotations	Cellular Component	Cytosol	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	Quinone Reductase (NADPH) Activity Oxidoreductase Activity Protein Homodimerization Activity Quinone Binding NADPH Binding	Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Selenium Binding Oxidoreductase Activity Identical Protein Binding
	Biological Process	NADP+ Metabolic Process	Response To Oxidative Stress Response To Lipid Hydroperoxide Hydrogen Peroxide Catabolic Process Cellular Oxidant Detoxification
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	Detoxification of Reactive Oxygen Species
Drugs			Glutathione Glutathione Glutathione disulfide Benzoyl peroxide
Diseases
GWAS			Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)
Interacting Genes		7 interacting genes: EEF1G FUNDC2 GPX3 MDM2 UBR1 UNC119 USP2-AS1	2 interacting genes: TP53I3 UBQLN1
Entrez ID		9540	2878
HPRD ID		05527	11750
Ensembl ID		ENSG00000115129	ENSG00000211445
Uniprot IDs		B4DMQ7 Q53FA7	P22352
PDB IDs		2J8Z 2OBY	2R37
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Store-operated Calcium Channel Activity Quinone Reductase (NADPH) Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway
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