PGAP3 and FBXL20

		PGAP3	FBXL20
Description		post-GPI attachment to proteins phospholipase 3	F-box and leucine rich repeat protein 20
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Membrane	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Synapse Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds	Protein Binding
	Biological Process	GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process	Behavioral Fear Response SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process At Presynapse, Modulating Synaptic Transmission Regulation Of Synaptic Vesicle Exocytosis
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Asthma ( 29273806 31619474 31959851) Asthma or allergic disease (pleiotropy) ( 29785011) Liver enzyme levels (alkaline phosphatase) ( 33972514) Menopause (age at onset) ( 26414677) Pancreatic ductal adenocarcinoma ( 30541042) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Triglyceride levels ( 30108155)	Asthma ( 31619474) Coronary artery disease ( 29212778) Creatinine levels ( 31015462) Estimated glomerular filtration rate in non-diabetics ( 31451708) FEV1 ( 30804560) Glomerular filtration rate (creatinine) ( 26831199) Hemoglobin levels ( 32327693) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Lung function (FVC) ( 30804560) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Microalbuminuria ( 31511532) Platelet count ( 32888494) Rapid automised naming of pictures ( 30741946) Red cell distribution width ( 32888494) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Ulcerative colitis ( 20228799) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes			5 interacting genes: BAX BBC3 PIK3C3 SKP1 UBE2D1
Entrez ID		93210	84961
HPRD ID		15118	10951
Ensembl ID		ENSG00000161395	ENSG00000108306
Uniprot IDs		A8K0P7 J3QKU0 Q96FM1	J3KTA1 Q96IG2
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Catabolic Process At Presynapse, Modulating Synaptic Transmission Presynaptic Modulation Of Chemical Synaptic Transmission SCF Ubiquitin Ligase Complex SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Behavioral Fear Response Multicellular Organismal Response To Stress Regulation Of Synaptic Vesicle Exocytosis Behavioral Defense Response Fear Response Circadian Regulation Of Gene Expression Binding Of Sperm To Zona Pellucida Membrane Lipid Catabolic Process Zona Pellucida Receptor Complex Acrosome Assembly Secretory Granule Organization Cell-cell Recognition Negative Regulation Of Immunoglobulin Production Sperm-egg Recognition Regulation Of Neurotransmitter Secretion Cell Body Regulation Of Immunoglobulin Production	Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of IRE1-mediated Unfolded Protein Response Release Of Cytochrome C From Mitochondria Execution Phase Of Apoptosis T Cell Apoptotic Process Positive Regulation Of Leukocyte Apoptotic Process Lymphocyte Apoptotic Process Regulation Of Endoplasmic Reticulum Unfolded Protein Response Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Release Of Cytochrome C From Mitochondria Leukocyte Apoptotic Process Regulation Of Epithelial Cell Apoptotic Process Regulation Of Lymphocyte Apoptotic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Intrinsic Apoptotic Signaling Pathway T Cell Homeostatic Proliferation Positive Regulation Of Neuron Apoptotic Process BAX Complex Apoptotic Mitochondrial Changes Release Of Matrix Enzymes From Mitochondria Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage B Cell Negative Selection Positive Regulation Of Motor Neuron Apoptotic Process BAK Complex Regulation Of Response To Endoplasmic Reticulum Stress Glycolipid Metabolic Process Response To Radiation B Cell Receptor Apoptotic Signaling Pathway B Cell Homeostatic Proliferation Signal Transduction By P53 Class Mediator Phosphatidylinositol Biosynthetic Process Protein K48-linked Ubiquitination Apoptotic Process Involved In Embryonic Digit Morphogenesis Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death Regulation Of Mitochondrion Organization Regulation Of Nitrogen Utilization Apoptotic Process Involved In Mammary Gland Involution Retinal Cell Programmed Cell Death F-box Domain Binding Positive Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Positive Regulation Of Programmed Cell Death Response To Ionizing Radiation Positive Regulation Of B Cell Apoptotic Process
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