PGAP3

Description		post-GPI attachment to proteins phospholipase 3
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Membrane
	Molecular Function	Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds
	Biological Process	GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process
Pathways
Drugs
Diseases
GWAS		Asthma ( 29273806 31619474 31959851) Asthma or allergic disease (pleiotropy) ( 29785011) Liver enzyme levels (alkaline phosphatase) ( 33972514) Menopause (age at onset) ( 26414677) Pancreatic ductal adenocarcinoma ( 30541042) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Triglyceride levels ( 30108155)
Novel Interacting Genes		2 novel interacting genes: FBXL20 ZPBP2
Interacting Genes
Entrez ID		93210
HPRD ID		15118
Ensembl ID		ENSG00000161395
Uniprot IDs		A8K0P7 J3QKU0 Q96FM1
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Catabolic Process At Presynapse, Modulating Synaptic Transmission Presynaptic Modulation Of Chemical Synaptic Transmission SCF Ubiquitin Ligase Complex SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Behavioral Fear Response Multicellular Organismal Response To Stress Regulation Of Synaptic Vesicle Exocytosis Behavioral Defense Response Fear Response Circadian Regulation Of Gene Expression Binding Of Sperm To Zona Pellucida Membrane Lipid Catabolic Process Zona Pellucida Receptor Complex Acrosome Assembly Secretory Granule Organization Cell-cell Recognition Negative Regulation Of Immunoglobulin Production Sperm-egg Recognition Regulation Of Neurotransmitter Secretion Cell Body Regulation Of Immunoglobulin Production
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