NEURL3 and LMAN2L

		NEURL3	LMAN2L
Description		neuralized E3 ubiquitin protein ligase 3	lectin, mannose binding 2 like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Early Endosome	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Membrane COPII-coated ER To Golgi Transport Vesicle
	Molecular Function	Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding D-mannose Binding Carbohydrate Binding Metal Ion Binding
	Biological Process	Immune System Process Protein Ubiquitination Negative Regulation Of MAPK Cascade Innate Immune Response Ubiquitin-dependent Endocytosis ERK1 And ERK2 Cascade Positive Regulation Of Proteasomal Protein Catabolic Process	Protein Folding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport
Pathways			COPII-mediated vesicle transport Cargo concentration in the ER
Drugs
Diseases
GWAS		Pulse pressure ( 30578418)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 20351715 21926972 22182935 28072414 31043756 34002096) Blood protein levels ( 30072576)
Interacting Genes		3 interacting genes: CCNDBP1 CFLAR UBC	2 interacting genes: MAL ZDHHC17
Entrez ID		93082	81562
HPRD ID		14296	17286
Ensembl ID		ENSG00000163121	ENSG00000114988
Uniprot IDs		A0A087WVI2 A0A087WXE0 Q96EH8	B4DI83 B4DVH1 B4E308 Q9H0V9
PDB IDs
Enriched GO Terms of Interacting Partners?		Ripoptosome Negative Regulation Of Hepatocyte Apoptotic Process Skeletal Myofibril Assembly Negative Regulation Of Myoblast Fusion Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Death-inducing Signaling Complex Skeletal Muscle Atrophy CD95 Death-inducing Signaling Complex Skeletal Muscle Adaptation Striated Muscle Atrophy Positive Regulation Of Glomerular Mesangial Cell Proliferation Muscle Atrophy Positive Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Hepatocyte Proliferation Regulation Of Glomerular Mesangial Cell Proliferation Protein Tag Activity Regulation Of Skeletal Muscle Cell Proliferation Cellular Response To Nitric Oxide Death Receptor Binding Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Hepatocyte Proliferation Regulation Of Skeletal Muscle Satellite Cell Proliferation Cellular Response To Reactive Nitrogen Species Regulation Of Myoblast Fusion Skeletal Muscle Tissue Regeneration Response To Nitric Oxide D-mannose Binding	Lumenal Side Of Membrane Glycerol Transmembrane Transporter Activity Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Response To Water Deprivation Water Transmembrane Transporter Activity Cellular Response To Mercury Ion Cellular Response To Water Deprivation Cytoplasmic Vesicle Membrane Protein Localization To Paranode Region Of Axon Membrane Raft Polarization Peptidase Activator Activity Involved In Apoptotic Process Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity Ubiquitin-dependent Endocytosis Response To Water Polyol Transmembrane Transport Renal Water Transport Glycerol Transmembrane Transport Metanephric Collecting Duct Development Response To Mercury Ion Protein Localization To Axon Schmidt-Lanterman Incisure Membrane Raft Distribution Membrane Raft Localization Structural Constituent Of Myelin Sheath Regulation Of Neurotrophin TRK Receptor Signaling Pathway Mucociliary Clearance Molecular Carrier Activity Type 2 Immune Response Collecting Duct Development Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Central Nervous System Myelination Lipid Transfer Activity Vacuolar Proton-transporting V-type ATPase, V1 Domain Water Channel Activity Golgi-associated Vesicle Membrane Vacuolar Proton-transporting V-type ATPase Complex Apical Protein Localization Ubiquinone Biosynthetic Process
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