NDUFAF2 and SLC30A5

		NDUFAF2	SLC30A5
Description		NADH:ubiquinone oxidoreductase complex assembly factor 2	solute carrier family 30 member 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex I	Golgi Membrane Nucleoplasm Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Apical Plasma Membrane Secretory Granule Transport Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle Golgi Cisterna Membrane Trans-Golgi Network Membrane Golgi Cis Cisterna Membrane
	Molecular Function	Protein Binding Protein-containing Complex Binding	Zinc Ion Transmembrane Transporter Activity Protein Binding Monoatomic Cation Transmembrane Transporter Activity Cadmium Ion Transmembrane Transporter Activity Antiporter Activity Zinc Efflux Transmembrane Transporter Activity Metal Ion Binding Zinc:proton Antiporter Activity
	Biological Process	Cell Projection Organization Mitochondrial Respiratory Chain Complex I Assembly Cilium Assembly Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus	GPI Anchor Biosynthetic Process Monoatomic Ion Transport Monoatomic Cation Transport Cobalt Ion Transport Zinc Ion Transport Intracellular Zinc Ion Homeostasis Response To Zinc Ion Insulin Processing Transmembrane Transport Zinc Ion Import Into Organelle Zinc Ion Transmembrane Transport Zinc Ion Import Across Plasma Membrane Zinc Ion Import Into Golgi Lumen
Pathways		Complex I biogenesis	Insulin processing Zinc efflux and compartmentalization by the SLC30 family
Drugs
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (MOSTest) ( 32665545) Cortical volume ( 32963231) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Parkinson's disease ( 27182965) Subcortical volume (MOSTest) ( 32665545)	Isovolumetric relaxation time ( 28394258) Liver enzyme levels (alkaline phosphatase) ( 33972514) Metabolite levels ( 23823483) Systolic blood pressure ( 30224653)
Interacting Genes		9 interacting genes: CYB5B LAT LPAR3 SEC22B SMIM1 SPG21 STX8 TMEM201 TMEM97
Entrez ID		91942	64924
HPRD ID		14288	06381
Ensembl ID		ENSG00000164182	ENSG00000145740
Uniprot IDs		A0A0S2Z5U1 Q8N183	Q8TAD4
PDB IDs
Enriched GO Terms of Interacting Partners?		Collateral Sprouting	Negative Regulation Of Peptide Secretion Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Insulin Secretion NADH Dehydrogenase Complex Assembly Mitochondrial Respiratory Chain Complex I Assembly Respiratory Chain Complex I Negative Regulation Of Protein Secretion Negative Regulation Of Hormone Secretion Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Mitochondrial Respiratory Chain Complex Assembly Negative Regulation Of Protein Transport Negative Regulation Of Establishment Of Protein Localization Negative Regulation Of Secretion By Cell Regulation Of Peptide Hormone Secretion Regulation Of Insulin Secretion Negative Regulation Of Secretion Negative Regulation Of Protein Localization Regulation Of Hormone Secretion Cilium Assembly Regulation Of Protein Secretion Cilium Organization
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