IGFN1 and HOXD3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		IGFN1	HOXD3
Name		immunoglobulin like and fibronectin type III domain containing 1	homeobox D3
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Z Disc	Chromatin Nucleus Nucleoplasm Aggresome Nuclear Body
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	None	DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell-matrix Adhesion Notch Signaling Pathway Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Glossopharyngeal Nerve Morphogenesis Thyroid Gland Development Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Cartilage Development
Pathways		None	Activation of anterior HOX genes in hindbrain development during early embryogenesis
GWAS		Asthma ( 29273806 ) Height ( 28552196 )	Estimated glomerular filtration rate ( 31015462 ) Male-pattern baldness ( 28196072 29146897 ) Mucinous ovarian carcinoma ( 26075790 ) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507 ) Ovarian cancer ( 20852632 ) Pelvic organ prolapse (moderate/severe) ( 26545240 )
Interacting Genes		40 interacting genes: ACTMAP BANP BLZF1 COG6 CRX DDAH2 FXR2 GOLGA2 HIVEP1 HOXA1 HOXD3 KCTD9 KIFC3 KRT39 KRTAP6-2 LHX9 LZTS2 MEOX2 MID2 MYOD1 NHLRC4 PIBF1 PNMA1 POF1B POU6F2 PRKAR1B PRR23B SERTAD2 SPAG5 TAX1BP1 TRIM21 TRIM27 TRIM35 TRIM42 TRIP13 TSC1 UBAP2 USP54 ZNF620 ZNF688	7 interacting genes: ALX4 DDB1 HMGB1 HOXC8 IGFN1 NFKBID SMARCD1
Entrez ID		91156	3232
HPRD ID		16812	00863
Ensembl ID		ENSG00000163395	ENSG00000128652
Uniprot IDs		Q86VF2	P31249
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Suppression Of Viral Release By Host Negative Regulation Of Viral Transcription Regulation Of Viral Transcription Protein Binding Golgi Organization Protein Localization To Cytoskeleton Sequence-specific Double-stranded DNA Binding	Positive Regulation Of Leukocyte Differentiation Regulation Of Nucleotide-excision Repair Regulation Of Lymphocyte Differentiation Regulation Of T Cell Differentiation Positive Regulation Of Glucose Metabolic Process Epigenetic Regulation Of Gene Expression Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Damaged DNA Binding Positive Regulation Of Viral Process Regulation Of T Cell Activation Positive Regulation Of Cell Activation Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Regulation Of Leukocyte Cell-cell Adhesion Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Lymphocyte Activation Positive Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Cell-cell Adhesion Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Hemopoiesis Positive Regulation Of Cell Development Regulation Of Glucose Metabolic Process Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Cell Adhesion Negative Regulation Of Apoptotic Cell Clearance Regulation Of Cell-cell Adhesion Regulation Of Viral Life Cycle Regulation Of Lymphocyte Activation Skeletal System Morphogenesis Nucleus Regulation Of Alpha-beta T Cell Activation Positive Regulation Of T Cell Differentiation C-X-C Chemokine Binding Alphav-beta3 Integrin-HMGB1 Complex T-helper 1 Cell Activation Positive Regulation Of Mismatch Repair Regulation Of Viral Process Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of DNA Repair Positive Regulation By Virus Of Viral Protein Levels In Host Cell Regulation Of Mismatch Repair Regulation Of Cell Activation Plasmacytoid Dendritic Cell Activation Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Chromatin Remodeling Positive Regulation Of Small Molecule Metabolic Process Anterior/posterior Pattern Specification Base-excision Repair, AP Site Formation Via Deaminated Base Removal