TMEM67 and INTS8

		TMEM67	INTS8
Description		transmembrane protein 67	integrator complex subunit 8
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Centrosome Cytoskeleton Plasma Membrane Cilium Membrane Cytoplasmic Vesicle Membrane Ciliary Transition Zone MKS Complex Cell Projection Ciliary Membrane	Chromatin Nucleus Nucleoplasm Chromosome Integrator Complex INTAC Complex
	Molecular Function	Protein Binding Filamin Binding Unfolded Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Centrosome Duplication Cell Projection Organization Non-canonical Wnt Signaling Pathway ERAD Pathway Cilium Assembly	SnRNA Processing Regulation Of Transcription Elongation By RNA Polymerase II SnRNA 3'-end Processing Protein Localization To Chromatin RNA Polymerase II Transcription Initiation Surveillance
Pathways		Anchoring of the basal body to the plasma membrane	RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
Drugs
Diseases		Joubert syndrome Meckel syndrome (MKS); Meckel-Gruber syndrome Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2) COACH syndrome
GWAS			Keratoconus ( 33649486) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Molybdenum levels ( 26025379) Multiple sclerosis ( 31604244) Type 2 diabetes ( 25102180)
Interacting Genes		2 interacting genes: MKS1 UBQLN1	3 interacting genes: CTDP1 DSCAM RNF10
Entrez ID		91147	55656
HPRD ID		11324	08626
Ensembl ID		ENSG00000164953	ENSG00000164941
Uniprot IDs		C9JHI2 Q5HYA8	Q75QN2
PDB IDs		7FH1	7CUN 7PKS 7YCX 8RBX 8RBZ 8RC4 8YJB 9EOF 9EP4
Enriched GO Terms of Interacting Partners?		Ciliary Transition Zone Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Smoothened Signaling Pathway Smoothened Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Kinase Binding Regulation Of Lysosomal Membrane Permeability Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Organelle Assembly Common Bile Duct Development Cell Surface Receptor Signaling Pathway Involved In Heart Development Centriole Negative Regulation Of Lysosomal Protein Catabolic Process Multivesicular Body, Internal Vesicle Negative Regulation Of Transforming Growth Factor Beta1 Production Membrane Tubulation Aggrephagy Regulation Of Toll-like Receptor 3 Signaling Pathway Cellular Component Assembly MKS Complex Cilium Organization Ciliary Basal Body Cilium Assembly Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Ceramide Binding Regulation Of Lysosome Organization Lysosomal Membrane Organization Phosphatidylinositol Bisphosphate Binding Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Production Sperm Annulus Mitochondrial Crista	Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding TFIIF-class Transcription Factor Complex Binding Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Arginylation Arginyl-tRNA--protein Transferase Activity Netrin-activated Signaling Pathway Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Cell Growth Dendrite Self-avoidance Regulation Of Developmental Growth Positive Regulation Of Axon Extension Involved In Axon Guidance Camera-type Eye Photoreceptor Cell Differentiation Eye Photoreceptor Cell Differentiation Dendritic Spine Development Regulation Of Multicellular Organismal Development Regulation Of Neurogenesis Tat Protein Binding Host-mediated Activation Of Viral Transcription Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Protein Metabolic Process Exit From Mitosis Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Negative Regulation Of Glial Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Proteolysis Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Protein Targeting To Vacuole Involved In Autophagy Protein K27-linked Ubiquitination Negative Regulation Of Centrosome Duplication MKS Complex Filamin Binding Positive Regulation Of Myelination Photoreceptor Cell Differentiation Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Nervous System Development Regulation Of Cell Differentiation Protein Modification Process Negative Regulation Of Cardiac Muscle Tissue Growth
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