INTS8

Name	integrator complex subunit 8
Structure
Novel Interactors	2 novel interactors: ATE1 TMEM67
Interactors	3 interactors: CTDP1 DSCAM RNF10
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Integrator Complex INTAC Complex
	Molecular Function	Protein Binding
	Biological Process	SnRNA Processing Regulation Of Transcription Elongation By RNA Polymerase II SnRNA 3'-end Processing Protein Localization To Chromatin RNA Polymerase II Transcription Initiation Surveillance
Pathways	RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
GWAS	Keratoconus ( 33649486 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Molybdenum levels ( 26025379 ) Multiple sclerosis ( 31604244 ) Type 2 diabetes ( 25102180 )
Entrez ID	55656
HPRD ID	08626
Ensembl ID	ENSG00000164941
Uniprot IDs	Q75QN2
PDB IDs	7CUN 7PKS 7YCX 8RBX 8RBZ 8RC4 8YJB 9EOF 9EP4
GO Terms Enriched among Interactors ?	Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding TFIIF-class Transcription Factor Complex Binding Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Arginylation Arginyl-tRNA--protein Transferase Activity Netrin-activated Signaling Pathway Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Cell Growth Dendrite Self-avoidance Regulation Of Developmental Growth Positive Regulation Of Axon Extension Involved In Axon Guidance Camera-type Eye Photoreceptor Cell Differentiation Eye Photoreceptor Cell Differentiation Dendritic Spine Development Regulation Of Multicellular Organismal Development Regulation Of Neurogenesis Tat Protein Binding Host-mediated Activation Of Viral Transcription Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Protein Metabolic Process Exit From Mitosis Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Negative Regulation Of Glial Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Proteolysis Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Protein Targeting To Vacuole Involved In Autophagy Protein K27-linked Ubiquitination Negative Regulation Of Centrosome Duplication MKS Complex Filamin Binding Positive Regulation Of Myelination Photoreceptor Cell Differentiation Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Nervous System Development Regulation Of Cell Differentiation Protein Modification Process Negative Regulation Of Cardiac Muscle Tissue Growth