HPS4 and HPS1

Number of citations of the paper that reports this interaction (PMID 12756248)
26

Data Source:
HPRD (in vivo)

		HPS4	HPS1
Gene Name		Hermansky-Pudlak syndrome 4	Hermansky-Pudlak syndrome 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosome Membrane BLOC-3 Complex Melanosome Platelet Dense Granule	Cytoplasm Lysosome Integral Component Of Plasma Membrane Cytoplasmic Membrane-bounded Vesicle BLOC-3 Complex
	Molecular Function	Protein Binding Protein Homodimerization Activity Protein Dimerization Activity	Protein Binding Protein Dimerization Activity
	Biological Process	Protein Targeting Lysosome Organization Blood Coagulation Hemostasis Melanocyte Differentiation Positive Regulation Of Eye Pigmentation Protein Stabilization	Lysosome Organization Blood Coagulation Visual Perception Melanocyte Differentiation Positive Regulation Of Natural Killer Cell Activation Secretion Of Lysosomal Enzymes Eye Pigmentation Retina Development In Camera-type Eye
Pathways
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		2 interactors: HPS1 RAC1	2 interactors: HPS4 PSEN2
Entrez ID		89781	3257
HPRD ID		05983	05403
Ensembl ID		ENSG00000100099	ENSG00000107521
Uniprot IDs		A8K2E6 Q6P1K3 Q9NQG7	Q658M9 Q92902
PDB IDs
Enriched GO Terms of Interacting Partners?		Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Positive Regulation Of Cell Activation Engulfment Of Apoptotic Cell Regulation Of Lymphocyte Activation Mast Cell Chemotaxis Blood Coagulation Hemostasis Regulation Of Cell Activation Eye Pigmentation Epithelial Cell Differentiation Secretion Of Lysosomal Enzymes Tangential Migration From The Subventricular Zone To The Olfactory Bulb Regulation Of Body Fluid Levels Sensory Organ Development Wound Healing Olfactory Bulb Interneuron Development Regulation Of Hydrogen Peroxide Metabolic Process Response To Wounding Regulation Of Respiratory Burst Auditory Receptor Cell Morphogenesis Phagocytosis, Engulfment Olfactory Bulb Interneuron Differentiation Positive Regulation Of Lamellipodium Assembly Auditory Receptor Cell Development Positive Regulation Of Immune System Process Dopaminergic Neuron Differentiation Membrane Invagination Positive Regulation Of Lamellipodium Organization Negative Regulation Of Receptor-mediated Endocytosis Wnt Signaling Pathway, Planar Cell Polarity Pathway Anatomical Structure Arrangement Ruffle Assembly Hyperosmotic Response Positive Regulation Of Neutrophil Chemotaxis Regulation Of Lamellipodium Assembly Positive Regulation Of Focal Adhesion Assembly Regulation Of Defense Response To Virus By Virus Positive Regulation Of Adherens Junction Organization Cochlea Morphogenesis Positive Regulation Of Natural Killer Cell Activation Epithelium Development Positive Regulation Of Granulocyte Chemotaxis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Non-canonical Wnt Signaling Pathway Apoptotic Cell Clearance Auditory Receptor Cell Differentiation	Positive Regulation Of Eye Pigmentation Regulation Of Eye Pigmentation Amyloid Precursor Protein Catabolic Process Positive Regulation Of Developmental Pigmentation Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Membrane Protein Ectodomain Proteolysis Beta-amyloid Metabolic Process Amyloid Precursor Protein Metabolic Process Notch Receptor Processing Regulation Of Developmental Pigmentation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Epithelium Development Regulation Of Epidermal Growth Factor-activated Receptor Activity Endoplasmic Reticulum Calcium Ion Homeostasis Dorsal/ventral Neural Tube Patterning Membrane Protein Proteolysis Positive Regulation Of Coagulation Melanocyte Differentiation Brain Morphogenesis Protein Transport Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Establishment Of Protein Localization Neuroepithelial Cell Differentiation Cardiac Muscle Contraction Lung Alveolus Development Negative Regulation Of Protein Binding Lysosome Organization Thymus Development Neural Tube Patterning Regulation Of Protein Tyrosine Kinase Activity Heart Contraction Tissue Development T Cell Activation Involved In Immune Response Developmental Pigmentation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Protein Localization Somitogenesis Striated Muscle Contraction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Protein Stabilization Hair Follicle Development Hair Cycle Process Cell Fate Specification Somite Development Negative Regulation Of Binding Ephrin Receptor Signaling Pathway Vacuole Organization Hair Cycle
Tagcloud ?			abnormal ad appear appsw brains damaged excessive find gtpases happ hippocampal impair mfn1 mfn2 mitochondria mitochondrial mitofusin morphology neurogenesis obscure pathogenesis plaque preventive propose prp sh swedish sy5y theanine
Tagcloud (Difference) ?			abnormal ad appear appsw brains damaged excessive find gtpases happ hippocampal impair mfn1 mfn2 mitochondria mitochondrial mitofusin morphology neurogenesis obscure pathogenesis plaque preventive propose prp sh swedish sy5y theanine
Tagcloud (Intersection) ?