MARCO and NAT14

		MARCO	NAT14
Description		macrophage receptor with collagenous structure	N-acetyltransferase 14 (putative)
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Collagen Trimer Cytoplasm Plasma Membrane Membrane Endocytic Vesicle Membrane	Nucleus Membrane
	Molecular Function	Amyloid-beta Binding G Protein-coupled Receptor Binding Transmembrane Signaling Receptor Activity Cargo Receptor Activity Pattern Recognition Receptor Activity	DNA Binding Protein Binding N-acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups
	Biological Process	Immune System Process Endocytosis Receptor-mediated Endocytosis Phagocytosis, Engulfment Cell Surface Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Apoptotic Cell Clearance Innate Immune Response Positive Regulation Of ERK1 And ERK2 Cascade Amyloid-beta Clearance	DNA-templated Transcription Initiation Positive Regulation Of DNA-templated Transcription
Pathways		Scavenging by Class A Receptors Scavenging by Class A Receptors
Drugs		Titanium dioxide Silicon dioxide
Diseases
GWAS		Lung function (FVC) ( 30061609) Medication use (adrenergics, inhalants) ( 31015401) Triglyceride levels ( 32203549)	Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		3 interacting genes: SCGB3A1 SCGB3A2 SNCA	7 interacting genes: ADRB2 CCR4 F2RL1 HTR2B JUN RABAC1 YAE1
Entrez ID		8685	57106
HPRD ID		05337	10036
Ensembl ID		ENSG00000019169	ENSG00000090971
Uniprot IDs		Q4ZG40 Q9UEW3	Q8WUY8
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Dopamine Uptake Involved In Synaptic Transmission Mitochondrial ATP Synthesis Coupled Electron Transport Cuprous Ion Binding Regulation Of Chaperone-mediated Autophagy Response To Iron(II) Ion Dopamine Biosynthetic Process Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Phosphorylation Regulation Of Acyl-CoA Biosynthetic Process Supramolecular Fiber Catecholamine Uptake Dopamine Uptake Positive Regulation Of Inositol Phosphate Biosynthetic Process Positive Regulation Of Neurotransmitter Secretion Regulation Of SNARE Complex Assembly Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Microtubule Polymerization SNARE Complex Assembly Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway ATP Synthesis Coupled Electron Transport Platelet Alpha Granule Membrane Dynein Complex Binding Synaptic Vesicle Priming Extracellular Space Dopamine Transport Inclusion Body Positive Regulation Of Receptor Recycling Neurotransmitter Reuptake Catecholamine Biosynthetic Process Cellular Response To Epinephrine Stimulus Response To Magnesium Ion Behavioral Response To Cocaine Phospholipase Binding Regulation Of Neurotransmitter Uptake	G Protein-coupled Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Modulation Of Process Of Another Organism Blood Vessel Diameter Maintenance G Protein-coupled Receptor Activity Regulation Of Tube Size G-protein Alpha-subunit Binding Positive Regulation Of Protein-containing Complex Disassembly Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Mini Excitatory Postsynaptic Potential Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Vasodilation Smooth Muscle Contraction Positive Regulation Of Intracellular Signal Transduction Vascular Process In Circulatory System Beta2-adrenergic Receptor Activity Proteinase-activated Receptor Activity Positive Regulation Of Eosinophil Degranulation Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Leading Edge Cell Differentiation Behavioral Response To Starvation Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Early Endosome Amyloid-beta Binding Beta-adrenergic Receptor Activity Circulatory System Process Positive Regulation Of Glomerular Filtration Regulation Of Renin Secretion Into Blood Stream Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process Cellular Response To Anisomycin Positive Regulation Of Endothelial Cell Proliferation
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