KLF7 and FBXO38

Number of citations of the paper that reports this interaction (PubMedID 14729953)
38

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		KLF7	FBXO38
Description		KLF transcription factor 7	F-box protein 38
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Nucleus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Axonogenesis Axon Guidance Glucose Homeostasis Regulation Of Epidermal Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Dendrite Morphogenesis Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Adipose Tissue Development	Adaptive Immune Response Immune System Process Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of Neuron Projection Development Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Protein K48-linked Ubiquitination
Pathways
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Childhood asthma exacerbations in long-acting beta2-agonist treatment ( 33706416) Chromosomal aberration frequency (chromatid type) in genotoxic compound exposure ( 31586183) Diastolic blood pressure ( 30224653) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Lachrymal/Salivary gland lesion in type 1 autoimmune pancreatitis ( 25985088) Pediatric central nervous system tumors (pleiotropy) ( 33226468) Platelet distribution width ( 32888494) Red blood cell count ( 27863252 32888494) Self-rated health ( 27864402) Smoking status (ever vs never smokers) ( 30643258) Urinary albumin excretion (no hypertensive medication) ( 30220432)	Chronic obstructive pulmonary disease ( 33909500) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Lung function (FEV1/FVC) ( 31453325) Lung function (FEV1/FVC) variance ( 31453325) Mean reticulocyte volume ( 32888494) Periodontal microbiota ( 22699663) Zinc levels ( 26025379)
Interacting Genes		2 interacting genes: APP FBXO38	9 interacting genes: ABL2 APP CREBBP KLF7 PPM1G RING1 SOX30 SUMO2 USP7
Entrez ID		8609	81545
HPRD ID		07279	09775
Ensembl ID		ENSG00000118263	ENSG00000145868
Uniprot IDs		O75840	Q6AZE0 Q6PIJ6
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization IMP Dehydrogenase Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Peptidase Activator Activity Positive Regulation Of Cell Activation Regulation Of Proteolysis Regulation Of Protein Catabolic Process Cellular Response To Manganese Ion Immune System Process Heparan Sulfate Binding Signaling Receptor Activator Activity GTP Biosynthetic Process 'de Novo' XMP Biosynthetic Process Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle	Protein Modification Process Positive Regulation Of T Cell Migration Positive Regulation Of Lymphocyte Migration Regulation Of Lymphocyte Migration Regulation Of T Cell Migration Negative Regulation Of Cell Communication Protein Metabolic Process Negative Regulation Of Signaling Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of RNA Metabolic Process Chromatin Remodeling Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Regulation Of DNA-templated Transcription Amylin Binding Regulation Of RNA Biosynthetic Process Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Post-translational Protein Modification P53 Binding Positive Regulation Of RNA Biosynthetic Process Regulation Of Protein Catabolic Process Regulation Of Protein Localization Positive Regulation Of DNA-templated Transcription Nuclear Body Nucleoplasm Regulation Of Proteolysis Acetylcholine Receptor Activator Activity Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Lipoprotein Particle Positive Regulation Of Protein Import Histone H3K27 Acetyltransferase Activity Proacrosomal Vesicle Fusion Positive Regulation Of Mononuclear Cell Migration Regulation Of Metabolic Process PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of RNA Metabolic Process
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