ZNF503 and SAMD8

		ZNF503	SAMD8
Description		zinc finger protein 503	sterile alpha motif domain containing 8
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Transferase Activity Phosphotransferase Activity, For Other Substituted Phosphate Groups Sphingomyelin Synthase Activity Ceramide Cholinephosphotransferase Activity
	Biological Process	Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Neural Precursor Cell Proliferation G1 To G0 Transition Involved In Cell Differentiation	Lipid Metabolic Process Sphingolipid Metabolic Process Sphingomyelin Biosynthetic Process Ceramide Biosynthetic Process Regulation Of Ceramide Biosynthetic Process
Pathways			Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Mild obesity-related type 2 diabetes ( 34737425) Triglyceride levels ( 32203549) Type 2 diabetes ( 30718926)	Heel bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		10 interacting genes: ARID5A ATN1 DTX2 FOXH1 KRTAP19-1 KRTAP3-3 KRTAP6-2 PROP1 TENT5B TLE5	1 interacting genes: TGFBR1
Entrez ID		84858	142891
HPRD ID		15811	18014
Ensembl ID		ENSG00000165655	ENSG00000156671
Uniprot IDs		Q96F45	Q96LT4 V9HVY4
PDB IDs			8IJQ 8IJR 8W9W 8W9Y
Enriched GO Terms of Interacting Partners?		Transcription Corepressor Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Androgen Receptor Binding Intermediate Filament Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process	Positive Regulation Of Mesenchymal Stem Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Myofibroblast Differentiation Activin Receptor Complex Activin Receptor Activity, Type I Type II Transforming Growth Factor Beta Receptor Binding Ventricular Compact Myocardium Morphogenesis Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Parathyroid Gland Development Positive Regulation Of Tight Junction Disassembly Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Germ Cell Migration Positive Regulation Of Extracellular Matrix Assembly Vascular Endothelial Cell Proliferation Transforming Growth Factor Beta Receptor Activity Epicardium Morphogenesis Trophoblast Cell Migration Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endothelial Cell Activation Transforming Growth Factor Beta Receptor Activity, Type I Transforming Growth Factor Beta Ligand-receptor Complex G1 To G0 Transition Involved In Cell Differentiation Coronary Vasculature Morphogenesis Activin Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Ventricular Trabecula Myocardium Morphogenesis G1 To G0 Transition I-SMAD Binding K63-linked Deubiquitinase Activity Pharyngeal System Development Heart Trabecula Morphogenesis Transforming Growth Factor Beta Binding Serine/threonine Protein Kinase Complex Regulation Of Extracellular Matrix Assembly Filopodium Assembly Negative Regulation Of Cell Population Proliferation Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of Extracellular Matrix Organization Response To Cholesterol Positive Regulation Of Filopodium Assembly Cell Population Proliferation Negative Regulation Of Chondrocyte Differentiation Blastocyst Development Activin Receptor Signaling Pathway Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Cartilage Development Endothelial Cell Proliferation Regulation Of Cardiac Muscle Cell Proliferation
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