MRPL45 and FKBP10

		MRPL45	FKBP10
Description		mitochondrial ribosomal protein L45	FKBP prolyl isomerase 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Large Ribosomal Subunit Ribosome Ribonucleoprotein Complex	Mitochondrial Intermembrane Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Calcium Ion Binding Protein Binding FK506 Binding Isomerase Activity Metal Ion Binding
	Biological Process	Mitochondrial Translation	In Utero Embryonic Development Protein Folding Collagen Fibril Organization Aorta Morphogenesis Wound Healing Extracellular Matrix Assembly
Pathways
Drugs
Diseases			Bruck syndrome
GWAS		Ovarian cancer ( 23535730)	Appendicular lean mass ( 33097823) Eosinophil count ( 32888494)
Interacting Genes		6 interacting genes: CAVIN1 EMD PFDN5 PLEKHA3 PRKN TRIM23	4 interacting genes: CDC42 ELN OGT SLC2A4
Entrez ID		84311	60681
HPRD ID		14764	09522
Ensembl ID		ENSG00000278845	ENSG00000141756
Uniprot IDs		A0A087WU62 A0A087X2D5 B4DEF8	Q8NAG5 Q96AY3
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Amyloid Fibril Formation Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway TMEM240-body Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Glucokinase Activity Regulation Protein Catabolic Process At Presynapse Negative Regulation Of Intralumenal Vesicle Formation Mitochondrion To Lysosome Vesicle-mediated Transport Mitochondrion-derived Vesicle F-box Domain Binding Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Hydrogen Sulfide Negative Regulation Of Spontaneous Neurotransmitter Secretion Response To Curcumin RNA Polymerase III Assembly RNA Polymerase I Assembly RNA Polymerase II Core Complex Assembly Termination Of RNA Polymerase I Transcription RRNA Primary Transcript Binding Positive Regulation Of Intracellular Transport Golgi Membrane Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Fusion Cellular Response To L-glutamine Response To Hydrogen Sulfide Negative Regulation Of Exosomal Secretion Endoplasmic Reticulum Negative Regulation Of Supramolecular Fiber Organization Positive Regulation Of Autophagy Lewy Body Regulation Of Spontaneous Synaptic Transmission Type 2 Mitophagy Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Mitochondrial Fission Regulation Of Endosome Organization Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Positive Regulation Of Neurotransmitter Uptake Regulation Of Synaptic Vesicle Transport Free Ubiquitin Chain Polymerization Cellular Response To Dopamine Negative Regulation Of Mitochondrial Fusion Protein-containing Complex Negative Regulation Of Neurotransmitter Secretion Regulation Of Retrograde Transport, Endosome To Golgi	Circulatory System Process Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly
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