TMTC1 and OVCH1

		TMTC1	OVCH1
Description		transmembrane O-mannosyltransferase targeting cadherins 1	ovochymase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane	Extracellular Region
	Molecular Function	Mannosyltransferase Activity Dolichyl-phosphate-mannose-protein Mannosyltransferase Activity Protein Binding Transferase Activity	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	RNA Processing Protein Glycosylation Protein O-linked Glycosylation Via Mannose	Proteolysis Fertilization
Pathways
Drugs
Diseases
GWAS		Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Beta blocker survival benefit in heart failure with reduced ejection fraction (time to all cause mortality x beta blocker interaction) ( 33012170) Colorectal or endometrial cancer ( 26621817) Compulsion score in obsessive compulsive disorder ( 32063569) Heart failure ( 20445134) Hippocampal volume ( 29860282) Schizophrenia ( 22885689 25056061 28991256 29483656 30285260)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Metabolite levels ( 23823483)
Interacting Genes		1 interacting genes: ZDHHC17	1 interacting genes: USP7
Entrez ID		83857	341350
HPRD ID		12472	07138
Ensembl ID		ENSG00000133687	ENSG00000187950
Uniprot IDs		F8VTQ9 Q8IUR5
PDB IDs
Enriched GO Terms of Interacting Partners?		Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity Lipoprotein Transport Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein Palmitoylation Palmitoyltransferase Activity Regulation Of Modification Of Synaptic Structure Golgi-associated Vesicle Membrane Protein-cysteine S-palmitoyltransferase Activity Golgi To Vacuole Transport Golgi To Lysosome Transport Protein Lipidation	Symbiont-mediated Disruption Of Host Cell PML Body Wax Biosynthetic Process Alcohol-forming Very Long-chain Fatty Acyl-CoA Reductase Activity Alcohol-forming Long-chain Fatty Acyl-CoA Reductase Activity Dolichyl-phosphate-mannose-protein Mannosyltransferase Activity Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Retrograde Transport, Endosome To Golgi Monoubiquitinated Protein Deubiquitination DNA Alkylation Repair Protein O-linked Glycosylation Via Mannose Mannosyltransferase Activity Transcription-coupled Nucleotide-excision Repair Regulation Of Telomere Capping Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation K48-linked Deubiquitinase Activity Negative Regulation Of Gluconeogenesis Deubiquitinase Activity Long-chain Fatty-acyl-CoA Metabolic Process
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