TMTC1

Description		transmembrane O-mannosyltransferase targeting cadherins 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane
	Molecular Function	Mannosyltransferase Activity Dolichyl-phosphate-mannose-protein Mannosyltransferase Activity Protein Binding Transferase Activity
	Biological Process	RNA Processing Protein Glycosylation Protein O-linked Glycosylation Via Mannose
Pathways
Drugs
Diseases
GWAS		Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Beta blocker survival benefit in heart failure with reduced ejection fraction (time to all cause mortality x beta blocker interaction) ( 33012170) Colorectal or endometrial cancer ( 26621817) Compulsion score in obsessive compulsive disorder ( 32063569) Heart failure ( 20445134) Hippocampal volume ( 29860282) Schizophrenia ( 22885689 25056061 28991256 29483656 30285260)
Novel Interacting Genes		2 novel interacting genes: CCDC91 OVCH1
Interacting Genes		1 interacting genes: ZDHHC17
Entrez ID		83857
HPRD ID		12472
Ensembl ID		ENSG00000133687
Uniprot IDs		F8VTQ9 Q8IUR5
PDB IDs
Enriched GO Terms of Interacting Partners?		Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity Lipoprotein Transport Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein Palmitoylation Palmitoyltransferase Activity Regulation Of Modification Of Synaptic Structure Golgi-associated Vesicle Membrane Protein-cysteine S-palmitoyltransferase Activity Golgi To Vacuole Transport Golgi To Lysosome Transport Protein Lipidation
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