RPS6KL1 and LIN52

		RPS6KL1	LIN52
Description		ribosomal protein S6 kinase like 1	lin-52 DREAM MuvB core complex component
Image		No pdb structure
GO Annotations	Cellular Component	Ribosome Ribonucleoprotein Complex	Nucleoplasm DRM Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein Binding
	Biological Process		Regulation Of DNA-templated Transcription
Pathways			Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 Polo-like kinase mediated events Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin A:Cdk2-associated events at S phase entry
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depression ( 29700475) HDL cholesterol levels ( 32203549) Mood instability ( 29187730) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Chronotype ( 30696823) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278) Waist-hip ratio ( 28552196)
Interacting Genes			4 interacting genes: DYRK1A EPM2AIP1 MAGEA6 RBL2
Entrez ID		83694	91750
HPRD ID		18004	18708
Ensembl ID		ENSG00000198208	ENSG00000205659
Uniprot IDs		B4DSP6 Q9Y6S9	B3KN83 Q52LA3
PDB IDs			4YOO 6C48
Enriched GO Terms of Interacting Partners?		DRM Complex	Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Histone H3T45 Kinase Activity
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