NUDT12 and CAMK4

		NUDT12	CAMK4
Description		nudix hydrolase 12	calcium/calmodulin dependent protein kinase IV
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GO Annotations	Cellular Component	Nucleus Cytoplasm Peroxisome Peroxisomal Matrix	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Extracellular Exosome
	Molecular Function	NAD+ Diphosphatase Activity Magnesium Ion Binding Protein Binding Zinc Ion Binding NADPH Pyrophosphatase Activity Pyrophosphatase Activity Hydrolase Activity NADH Pyrophosphatase Activity Metal Ion Binding RNA NAD-cap (NMN-forming) Hydrolase Activity Catalytic Activity, Acting On RNA Phosphodiesterase Decapping Endonuclease Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	MRNA Catabolic Process NADP+ Catabolic Process MRNA Metabolic Process NAD+ Metabolic Process NAD+ Catabolic Process Circadian Regulation Of Gene Expression NAD+ Biosynthetic Process Via The Salvage Pathway Nucleobase-containing Compound Catabolic Process NAD-cap Decapping MRNA Methylguanosine-cap Decapping	Adaptive Immune Response Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Protein Phosphorylation Inflammatory Response Signal Transduction Long-term Memory Regulation Of T Cell Differentiation In Thymus Intracellular Signal Transduction Myeloid Dendritic Cell Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of DNA-templated Transcription
Pathways		Nicotinate metabolism	CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB Transcriptional activation of mitochondrial biogenesis CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Loss of phosphorylation of MECP2 at T308 Regulation of MECP2 expression and activity Negative regulation of NMDA receptor-mediated neuronal transmission
Drugs			K-00546 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one
Diseases
GWAS		Academic attainment (English) ( 33594131) Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Body size at age 10 ( 32376654) Depression (quantitative trait) ( 23290196) Fasting glucose change ( 31263163) Gut microbiota (functional units) ( 27694959) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Longevity ( 30294719) Mitochondrial DNA levels ( 25240745) Multiple sclerosis ( 31604244) Number of sexual partners ( 30643258) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Response to fenofibrate (total cholesterol levels) ( 27002377) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Triglyceride levels ( 32203549)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Allergy ( 27182965) Alzheimer's disease (cognitive decline) ( 23535033) Asthma ( 30929738 31959851 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Autoimmune thyroid disease ( 32581359) Blood pressure ( 17903302) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Medication use (thyroid preparations) ( 31015401) Motor coordination ( 34177493) Periodontitis (PAL4Q3) ( 24024966) Self-reported allergy ( 23817569) Type 1 diabetes ( 34012112)
Interacting Genes			10 interacting genes: CABIN1 CAMKK1 CAMKK2 CREBBP GAPDH HDAC4 NEDD4 NOS1 NOTCH1 RELA
Entrez ID		83594	814
HPRD ID		10123	07169
Ensembl ID		ENSG00000112874	ENSG00000152495
Uniprot IDs		Q9BQG2	Q16566
PDB IDs		6SCX	2W4O
Enriched GO Terms of Interacting Partners?		Myeloid Dendritic Cell Activation Regulation Of Dendritic Cell Cytokine Production Regulation Of T Cell Differentiation In Thymus Calcium/calmodulin-dependent Protein Kinase Activity Calcium-dependent Protein Serine/threonine Kinase Activity Nervous System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Myeloid Dendritic Cell Differentiation Positive Regulation Of Dendritic Cell Cytokine Production Protein Localization To Non-motile Cilium Photoreceptor Cell Cilium Long-term Memory Dendritic Cell Differentiation Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Photoreceptor Cell Development Eye Photoreceptor Cell Development	Peptidyl-cysteine S-nitrosylase Activity Chromatin DNA Binding Nucleus Nucleoplasm Cytosol Endocardial Cushion Development Negative Regulation Of Myotube Differentiation Response To Muramyl Dipeptide Calcium/calmodulin-dependent Protein Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Signal Transduction Response To UV Response To Stress Regulation Of Protein Sumoylation Negative Regulation Of Biosynthetic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Binding Regulation Of Gene Expression NADP Binding Calmodulin Binding Positive Regulation Of Glial Cell Differentiation Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Regulation Of Myotube Differentiation Rhythmic Process Transcription Coactivator Binding Negative Regulation Of Metabolic Process Immune System Process Positive Regulation Of Transcription By RNA Polymerase II Canonical NF-kappaB Signal Transduction Catabolic Process Mesenchyme Development Formation Of Structure Involved In A Symbiotic Process Cellular Response To Growth Factor Stimulus Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Venous Endothelial Cell Differentiation
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