NUDT12

Description		nudix hydrolase 12
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Peroxisome Peroxisomal Matrix
	Molecular Function	NAD+ Diphosphatase Activity Magnesium Ion Binding Protein Binding Zinc Ion Binding NADPH Pyrophosphatase Activity Pyrophosphatase Activity Hydrolase Activity NADH Pyrophosphatase Activity Metal Ion Binding RNA NAD-cap (NMN-forming) Hydrolase Activity Catalytic Activity, Acting On RNA Phosphodiesterase Decapping Endonuclease Activity
	Biological Process	MRNA Catabolic Process NADP+ Catabolic Process MRNA Metabolic Process NAD+ Metabolic Process NAD+ Catabolic Process Circadian Regulation Of Gene Expression NAD+ Biosynthetic Process Via The Salvage Pathway Nucleobase-containing Compound Catabolic Process NAD-cap Decapping MRNA Methylguanosine-cap Decapping
Pathways		Nicotinate metabolism
Drugs
Diseases
GWAS		Academic attainment (English) ( 33594131) Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Body size at age 10 ( 32376654) Depression (quantitative trait) ( 23290196) Fasting glucose change ( 31263163) Gut microbiota (functional units) ( 27694959) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Longevity ( 30294719) Mitochondrial DNA levels ( 25240745) Multiple sclerosis ( 31604244) Number of sexual partners ( 30643258) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Response to fenofibrate (total cholesterol levels) ( 27002377) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Triglyceride levels ( 32203549)
Novel Interacting Genes		2 novel interacting genes: CAMK4 RPGR
Interacting Genes
Entrez ID		83594
HPRD ID		10123
Ensembl ID		ENSG00000112874
Uniprot IDs		Q9BQG2
PDB IDs		6SCX
Enriched GO Terms of Interacting Partners?		Myeloid Dendritic Cell Activation Regulation Of Dendritic Cell Cytokine Production Regulation Of T Cell Differentiation In Thymus Calcium/calmodulin-dependent Protein Kinase Activity Calcium-dependent Protein Serine/threonine Kinase Activity Nervous System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Myeloid Dendritic Cell Differentiation Positive Regulation Of Dendritic Cell Cytokine Production Protein Localization To Non-motile Cilium Photoreceptor Cell Cilium Long-term Memory Dendritic Cell Differentiation Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Photoreceptor Cell Development Eye Photoreceptor Cell Development
Tagcloud ?