SH3BGRL3 and TNFRSF8

		SH3BGRL3	TNFRSF8
Description		SH3 domain binding glutamate rich protein like 3	TNF receptor superfamily member 8
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Body Ruffle Membrane Cell Projection Extracellular Exosome	Nucleoplasm Cytoplasm Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Glutathione Transferase Activity Protein Binding	Protease Binding Transmembrane Signaling Receptor Activity
	Biological Process	Cytoskeleton Organization	Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of TRAIL Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus
Pathways			TNFs bind their physiological receptors
Drugs			Iratumumab XmAb 2513 Brentuximab vedotin
Diseases
GWAS			Asthma ( 31959851 32296059 34103634) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Serum alkaline phosphatase levels ( 33339817) Sum eosinophil basophil counts ( 27863252) Tuberculosis ( 29036319)
Interacting Genes		5 interacting genes: APP CDC42 DDIT4L EGFR ERBB2	7 interacting genes: ALK TDP2 TNFSF8 TRAF1 TRAF2 TRAF3 TRAF5
Entrez ID		83442	943
HPRD ID		15332	01074
Ensembl ID		ENSG00000142669	ENSG00000120949
Uniprot IDs		Q9H299	A5D8T4 P28908
PDB IDs		1SJ6	1D01
Enriched GO Terms of Interacting Partners?		ERBB2-EGFR Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of Growth Receptor Complex Regulation Of MAPK Cascade Positive Regulation Of Cell Growth Positive Regulation Of Epithelial Cell Proliferation ERBB2 Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Population Proliferation Transmembrane Signaling Receptor Activity Positive Regulation Of Growth Positive Regulation Of Phosphate Metabolic Process Neuron Projection Organization Regulation Of ERK1 And ERK2 Cascade Intracellular Signaling Cassette Response To Growth Factor Cellular Response To Growth Factor Stimulus Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Cycle Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Glial Cell Development Regulation Of Epithelial Cell Proliferation Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane Regulation Of Cell Growth Positive Regulation Of Intracellular Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of MiRNA Transcription Amylin Binding Positive Regulation Of Toll Signaling Pathway ERBB Signaling Pathway Multivesicular Body, Internal Vesicle Lumen Cell Junction Organization Regulation Of MiRNA Metabolic Process Neuron Projection Development Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Mitotic Cell Cycle Ruffle Membrane Acetylcholine Receptor Activator Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Apoptotic Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Lipoprotein Particle	Tumor Necrosis Factor Receptor Binding Thioesterase Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Positive Regulation Of DNA-binding Transcription Factor Activity CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Ubiquitin Protein Ligase Binding Cytoplasmic Side Of Plasma Membrane Regulation Of Canonical NF-kappaB Signal Transduction Identical Protein Binding Cytokine-mediated Signaling Pathway Signal Transduction Neuron Development Signal Transduction Involved In Regulation Of Gene Expression Cell Surface Receptor Signaling Pathway Receptor Complex Apoptotic Process Response To Environmental Enrichment Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Death Notochord Cell Development Programmed Cell Death TORC2 Complex Disassembly MWP Complex 5'-tyrosyl-DNA Phosphodiesterase Activity Tyrosyl-RNA Phosphodiesterase Activity Tyrosyl-DNA Phosphodiesterase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process MRNA Stabilization Swimming Behavior Axial Mesoderm Formation Response To Ketamine TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of RNA Metabolic Process Receptor Signaling Protein Tyrosine Kinase Activator Activity Core-binding Factor Complex Negative Regulation Of Lymphangiogenesis Notochord Formation I-kappaB Phosphorylation Negative Regulation Of Male Germ Cell Proliferation Protein Phosphorylation
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