MKKS and TMX4

		MKKS	TMX4
Description		MKKS centrosomal shuttling protein	thioredoxin related transmembrane protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Motile Cilium Ciliary Basal Body Kinociliary Basal Body	Nucleus Nuclear Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Unfolded Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Disulfide Oxidoreductase Activity
	Biological Process	Heart Looping Developmental Process Involved In Reproduction Protein Folding Spermatid Development Determination Of Left/right Symmetry Heart Development Visual Perception Sensory Perception Of Smell Gonad Development Gene Expression Negative Regulation Of Gene Expression Artery Smooth Muscle Contraction Striatum Development Hippocampus Development Cerebral Cortex Development Negative Regulation Of Actin Filament Polymerization Melanosome Transport Developmental Process Leptin-mediated Signaling Pathway Social Behavior Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of Multicellular Organism Growth Vasodilation Response To Leptin Fat Cell Differentiation Photoreceptor Cell Maintenance Negative Regulation Of Blood Pressure Intracellular Transport Animal Organ Development System Development Brain Morphogenesis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Chaperone-mediated Protein Complex Assembly Cartilage Development Regulation Of Stress Fiber Assembly Pigment Granule Aggregation In Cell Center Convergent Extension Involved In Gastrulation Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Face Development Response To Inositol Non-motile Cilium Assembly
Pathways		BBSome-mediated cargo-targeting to cilium
Drugs
Diseases		46,XX disorders of sex development (Other), including: Mullerian aplasia and hyperandrogenism; McKusick-Kaufman syndrome Bardet-Biedl syndrome (BBS)
GWAS			Chronic kidney disease ( 26420894) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535)
Interacting Genes		4 interacting genes: APP CDR2 PTN ZBED1
Entrez ID		8195	56255
HPRD ID		05356	11128
Ensembl ID		ENSG00000125863	ENSG00000125827
Uniprot IDs		B7Z3W9 Q9NPJ1	Q9H1E5
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Long-term Synaptic Potentiation Response To Auditory Stimulus Molecular Function Activator Activity Dendrite Membrane Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Dendrite Development Phospholipase C-activating Endothelin Receptor Signaling Pathway Protein Autosumoylation Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Leukocyte Chemotaxis Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Interleukin-15 Receptor Activity Interleukin-2 Binding Interleukin-2 Receptor Activity Interleukin-2 Receptor Complex Dendrite Regeneration Ossification Involved In Bone Remodeling Selenium Compound Metabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Memory Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Modulation Of Chemical Synaptic Transmission Axon Midline Choice Point Recognition Recycling Endosome Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Positive Regulation Of Chemotaxis	Pigment Granule Localization Establishment Of Melanosome Localization Regulation Of Response To Food Chaperone-mediated Protein Complex Assembly Tonic Smooth Muscle Contraction Artery Smooth Muscle Contraction Regulation Of Cilium Beat Frequency Negative Regulation Of Appetite Melanosome Localization Response To Leptin Pigment Granule Aggregation In Cell Center Kinociliary Basal Body Vascular Associated Smooth Muscle Contraction Brain Morphogenesis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Convergent Extension Striatum Development Convergent Extension Involved In Gastrulation Melanosome Transport Leptin-mediated Signaling Pathway Face Development Response To Inositol Pigment Granule Transport Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Regulation Of Appetite Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Detection Of Mechanical Stimulus Involved In Sensory Perception Vasoconstriction Positive Regulation Of Multicellular Organism Growth Regulation Of Response To Nutrient Levels Regulation Of Cilium Movement Photoreceptor Cell Maintenance Detection Of Mechanical Stimulus Negative Regulation Of Blood Pressure Non-motile Cilium Assembly Regulation Of Microtubule-based Movement Vasodilation Social Behavior Negative Regulation Of Actin Filament Polymerization Smooth Muscle Contraction Heart Looping Regulation Of Multicellular Organism Growth Embryonic Heart Tube Morphogenesis Hippocampus Development Sensory Perception Of Smell Cerebral Cortex Development Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Regulation Of Stress Fiber Assembly Cartilage Development
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