REXO5 and IGBP1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		REXO5	IGBP1
Description		RNA exonuclease 5	immunoglobulin binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Extracellular Exosome	Cytoplasm Cytosol
	Molecular Function	Nucleic Acid Binding RNA Binding Nuclease Activity Exonuclease Activity Hydrolase Activity	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase 2A Binding
	Biological Process	RRNA 3'-end Processing	Negative Regulation Of Transcription By RNA Polymerase II Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Stress-activated MAPK Cascade Response To Tumor Necrosis Factor Regulation Of Dephosphorylation Intracellular Signal Transduction B Cell Activation Regulation Of Microtubule-based Movement Response To Interleukin-1
Pathways
Drugs
Diseases			Corpus callosum, agenesis of, with mental retardation, ocular coloboma and micrognathia
GWAS
Interacting Genes		1 interacting genes: IGBP1	12 interacting genes: APP HSPB1 LINC01257 MID1 MID2 PPP2CA PPP4C PPP6C PYGM REXO5 S100A13 SHOX
Entrez ID		81691	3476
HPRD ID		17433	02140
Ensembl ID		ENSG00000005189	ENSG00000089289
Uniprot IDs		Q96IC2	P78318
PDB IDs			4IYP
Enriched GO Terms of Interacting Partners?		Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Protein Phosphatase Regulator Activity Regulation Of Stress-activated Protein Kinase Signaling Cascade Protein Phosphatase 2A Binding Regulation Of Dephosphorylation Inner Dynein Arm 9+2 Motile Cilium Dynein Intermediate Chain Binding Axonemal Dynein Complex Assembly Minus-end-directed Microtubule Motor Activity Inner Dynein Arm Assembly Dynein Light Intermediate Chain Binding Axonemal Dynein Complex Dynein Complex Regulation Of Microtubule-based Movement Microtubule Motor Activity	Positive Regulation Of Interleukin-1 Production RAGE Receptor Binding Protein Serine/threonine Phosphatase Activity Protein Localization To Microtubule Response To Lead Ion Regulation Of Interleukin-1 Production Protein Homodimerization Activity Phosphoprotein Phosphatase Activity Regulation Of Intracellular Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Protein Kinase C Signaling Protein Localization To Cytoskeleton Phosphoprotein Binding RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Positive Regulation Of Interleukin-1 Beta Production Regulation Of Carbohydrate Catabolic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of ATP Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Axo-dendritic Transport Regulation Of Signal Transduction Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Regulation Of Supramolecular Fiber Organization Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Extracellular Exosome Regulation Of Interleukin-1 Beta Production Protein Kinase C Inhibitor Activity Regulation Of Canonical NF-kappaB Signal Transduction Cytoskeleton Protein Dephosphorylation RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Glycogen Phosphorylase Activity Regulation Of Microtubule Polymerization Or Depolymerization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
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