USB1 and RNU6-1

Number of citations of the paper that reports this interaction (PubMedID 23022480)
0

Data Source:
BioGRID (enzymatic study)

		USB1	RNU6-1
Description		U6 snRNA biogenesis phosphodiesterase 1	RNA, U6 small nuclear 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Intercellular Bridge	U6 SnRNP U4/U6 X U5 Tri-snRNP Complex
	Molecular Function	3'-5'-RNA Exonuclease Activity Nuclease Activity Protein Binding Hydrolase Activity Lyase Activity Poly(U)-specific Exoribonuclease Activity, Producing 3' Uridine Cyclic Phosphate Ends	U4 SnRNA Binding
	Biological Process	RNA Splicing SnRNA 3'-end Processing U6 SnRNA 3'-end Processing	Spliceosomal Tri-snRNP Complex Assembly Formation Of Quadruple SL/U4/U5/U6 SnRNP
Pathways
Drugs
Diseases		Poikiloderma with neutropenia
GWAS			Cognitive performance ( 20125193) Cryptococcosis in HIV infection ( 33269293)
Interacting Genes		2 interacting genes: RNU6-1 SMAD4	4 interacting genes: METTL16 RBM22 SND1 USB1
Entrez ID		79650	26827
HPRD ID		07815
Ensembl ID		ENSG00000103005	ENSG00000206625
Uniprot IDs		H3BN52 H3BNM8 Q9BQ65
PDB IDs		4H7W 5V1M 6D2Z 6D30 6D31
Enriched GO Terms of Interacting Partners?		Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Gonad Morphogenesis Negative Regulation Of Cardiac Myofibril Assembly Nephrogenic Mesenchyme Morphogenesis Metanephric Mesenchyme Morphogenesis Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Formation Of Quadruple SL/U4/U5/U6 SnRNP SMAD Protein Complex Positive Regulation Of Luteinizing Hormone Secretion Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Atrioventricular Valve Formation Sebaceous Gland Development Heteromeric SMAD Protein Complex Formation Of Anatomical Boundary Brainstem Development Mesendoderm Development Sulfate Binding Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Transforming Growth Factor Beta2 Production Endocardial Cell Differentiation U4 SnRNA Binding Atrioventricular Canal Development Somite Rostral/caudal Axis Specification Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Cardiac Muscle Cell Differentiation Endothelial Cell Activation U6 SnRNP Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Negative Regulation Of Cardiocyte Differentiation Secondary Palate Development Filamin Binding Neural Crest Cell Differentiation Heart Valve Formation Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cardiac Muscle Cell Apoptotic Process I-SMAD Binding Cardiac Conduction System Development Interleukin-6-mediated Signaling Pathway Gastrulation With Mouth Forming Second Regulation Of Cell Proliferation Involved In Heart Morphogenesis Spliceosomal Tri-snRNP Complex Assembly Regulation Of Cardiac Muscle Cell Differentiation Seminiferous Tubule Development Regulation Of Hair Follicle Development Regulation Of Extracellular Matrix Assembly Uterus Development Female Gonad Development	RNA Metabolic Process SnRNA Processing SnRNA Metabolic Process RNAi Effector Complex Nucleic Acid Metabolic Process MRNA Metabolic Process SnRNA (adenine-N6)-methylation U6 SnRNA (adenine-(43)-N(6))-methyltransferase Activity Poly(U)-specific Exoribonuclease Activity, Producing 3' Uridine Cyclic Phosphate Ends Nuclease Activity MRNA Catabolic Process Nucleobase-containing Compound Metabolic Process RNA Processing U6 SnRNA 3'-end Binding U6 SnRNA 3'-end Processing Regulation Of RNA Splicing MRNA M(6)A Methyltransferase Activity RNA Catabolic Process S-adenosylmethionine Biosynthetic Process RISC Complex Binding Dense Body SnRNA Modification Negative Regulation Of 3'-UTR-mediated MRNA Stabilization RRNA Base Methylation RNA Binding Nucleobase-containing Compound Catabolic Process MiRNA Catabolic Process RNA Splicing U2-type Catalytic Step 1 Spliceosome S-adenosylmethionine Metabolic Process U6 SnRNA Binding Prp19 Complex MRNA Cis Splicing, Via Spliceosome MRNA Processing RNA Stem-loop Binding Pre-mRNA Binding Positive Regulation Of Protein Export From Nucleus MiRNA Metabolic Process RRNA Methylation SnRNA 3'-end Processing Macromolecule Metabolic Process Nucleic Acid Binding U2-type Catalytic Step 2 Spliceosome 3'-5'-RNA Exonuclease Activity RRNA Modification RNA Endonuclease Activity Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of RNA Splicing Regulation Of Protein Import Into Nucleus
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