METTL16 and RNU6-1

Number of citations of the paper that reports this interaction (PubMedID 28525753)
64

Data Source:
BioGRID (unspecified method)

		METTL16	RNU6-1
Description		methyltransferase 16, RNA N6-adenosine	RNA, U6 small nuclear 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	U6 SnRNP U4/U6 X U5 Tri-snRNP Complex
	Molecular Function	MRNA M(6)A Methyltransferase Activity RNA Binding Methyltransferase Activity Transferase Activity U6 SnRNA 3'-end Binding RNA Stem-loop Binding U6 SnRNA (adenine-(43)-N(6))-methyltransferase Activity	U4 SnRNA Binding
	Biological Process	RNA Methylation MRNA Processing MRNA Catabolic Process S-adenosylmethionine Biosynthetic Process RNA Modification Post-transcriptional Regulation Of Gene Expression Methylation Regulation Of MRNA Stability Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Catabolic Process MRNA Destabilization RRNA Base Methylation SnRNA (adenine-N6)-methylation Negative Regulation Of 3'-UTR-mediated MRNA Stabilization	Spliceosomal Tri-snRNP Complex Assembly Formation Of Quadruple SL/U4/U5/U6 SnRNP
Pathways
Drugs
Diseases
GWAS		Feeling miserable ( 29500382) Hip circumference adjusted for BMI ( 34021172) Red blood cell count ( 32888494)	Cognitive performance ( 20125193) Cryptococcosis in HIV infection ( 33269293)
Interacting Genes		2 interacting genes: APP RNU6-1	4 interacting genes: METTL16 RBM22 SND1 USB1
Entrez ID		79066	26827
HPRD ID		14556
Ensembl ID		ENSG00000127804	ENSG00000206625
Uniprot IDs		B7Z3X7 Q86W50
PDB IDs		2H00 6B91 6B92 6DU4 6DU5 6GFK 6GFN 6GT5 6M1U
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Formation Of Quadruple SL/U4/U5/U6 SnRNP Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition U4 SnRNA Binding Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion U6 SnRNP Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel High-density Lipoprotein Particle	RNA Metabolic Process SnRNA Processing SnRNA Metabolic Process RNAi Effector Complex Nucleic Acid Metabolic Process MRNA Metabolic Process SnRNA (adenine-N6)-methylation U6 SnRNA (adenine-(43)-N(6))-methyltransferase Activity Poly(U)-specific Exoribonuclease Activity, Producing 3' Uridine Cyclic Phosphate Ends Nuclease Activity MRNA Catabolic Process Nucleobase-containing Compound Metabolic Process RNA Processing U6 SnRNA 3'-end Binding U6 SnRNA 3'-end Processing Regulation Of RNA Splicing MRNA M(6)A Methyltransferase Activity RNA Catabolic Process S-adenosylmethionine Biosynthetic Process RISC Complex Binding Dense Body SnRNA Modification Negative Regulation Of 3'-UTR-mediated MRNA Stabilization RRNA Base Methylation RNA Binding Nucleobase-containing Compound Catabolic Process MiRNA Catabolic Process RNA Splicing U2-type Catalytic Step 1 Spliceosome S-adenosylmethionine Metabolic Process U6 SnRNA Binding Prp19 Complex MRNA Cis Splicing, Via Spliceosome MRNA Processing RNA Stem-loop Binding Pre-mRNA Binding Positive Regulation Of Protein Export From Nucleus MiRNA Metabolic Process RRNA Methylation SnRNA 3'-end Processing Macromolecule Metabolic Process Nucleic Acid Binding U2-type Catalytic Step 2 Spliceosome 3'-5'-RNA Exonuclease Activity RRNA Modification RNA Endonuclease Activity Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of RNA Splicing Regulation Of Protein Import Into Nucleus
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