EIF4H and LAT2

		EIF4H	LAT2
Description		eukaryotic translation initiation factor 4H	linker for activation of T cells family member 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm	Plasma Membrane Membrane Membrane Raft Extracellular Exosome
	Molecular Function	Nucleic Acid Binding RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding RNA Strand Annealing Activity RNA Strand-exchange Activity Ribosomal Small Subunit Binding Cadherin Binding	Protein Binding SH2 Domain Binding
	Biological Process	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Sexual Reproduction Developmental Growth Eukaryotic Translation Initiation Factor 4F Complex Assembly	Adaptive Immune Response Immune System Process Immune Response-regulating Signaling Pathway Calcium-mediated Signaling Intracellular Signal Transduction B Cell Activation Mast Cell Degranulation B Cell Receptor Signaling Pathway
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization
Drugs
Diseases
GWAS			Systemic lupus erythematosus ( 29848360)
Interacting Genes		8 interacting genes: C11orf68 CEBPA DDIT4L DLG3 FBXO17 LNX1 PICK1 SPG21	7 interacting genes: CBL GAB1 GRB2 PLCG1 PLCG2 SOS1 UBQLN4
Entrez ID		7458	7462
HPRD ID		11940	09304
Ensembl ID		ENSG00000106682	ENSG00000086730
Uniprot IDs		Q15056	Q9GZY6
PDB IDs			3MAZ
Enriched GO Terms of Interacting Partners?			Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc-epsilon Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Protein Kinase Binding Phosphotyrosine Residue Binding B Cell Receptor Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Insulin Receptor Signaling Pathway Immune Response-activating Signaling Pathway SH3 Domain Binding Phospholipase C Activity Immune Response-regulating Signaling Pathway Activation Of Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Schwann Cell Development Phosphatidylinositol-mediated Signaling Cell Surface Receptor Signaling Pathway Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Ephrin Receptor Binding Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Cytosol Epidermal Growth Factor Receptor Binding COP9 Signalosome Insulin-like Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Immune Response Protein Tyrosine Kinase Binding Phospholipid Catabolic Process Perinuclear Region Of Cytoplasm Positive Regulation Of Epithelial Cell Migration Phosphoric Diester Hydrolase Activity Positive Regulation Of Receptor-mediated Endocytosis Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Intracellular Signaling Cassette Glial Cell Development Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Epithelial Cell Migration Guanyl-nucleotide Exchange Factor Adaptor Activity Regulation Of ERBB Signaling Pathway Intracellular Signal Transduction Regulation Of Immune Response
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