LEFTY2 and ACSS3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		LEFTY2	ACSS3
Description		left-right determination factor 2	acyl-CoA synthetase short chain family member 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Platelet Alpha Granule Lumen	Mitochondrion Mitochondrial Matrix
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Growth Factor Activity	Nucleotide Binding Acetate-CoA Ligase Activity Protein Binding ATP Binding Ligase Activity Medium-chain Fatty Acid-CoA Ligase Activity Propionate-CoA Ligase Activity
	Biological Process	Anterior/posterior Axis Specification BMP Signaling Pathway	Lipid Metabolic Process Ketone Body Biosynthetic Process
Pathways		Platelet degranulation Signaling by NODAL Regulation of signaling by NODAL	Synthesis of Ketone Bodies MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS			Age-related cataracts (age at onset) ( 25352737) Alcohol consumption ( 31358974) Bitter alcoholic beverage consumption ( 31046077) Lateral orbital frontal cortex volume ( 31530798) Medial orbital frontal cortex volume ( 31530798) Pars orbitalis volume ( 31530798) Plasma amyloid beta peptide concentrations (ABx-42) ( 24535457) Prudent dietary pattern ( 28644415) Response to antidepressant treatment (citalopram) ( 23726668) Walking pace ( 33128006)
Interacting Genes		3 interacting genes: ACSS3 MAPK8IP2 SNCA	1 interacting genes: LEFTY2
Entrez ID		7044	79611
HPRD ID		03526	13385
Ensembl ID		ENSG00000143768	ENSG00000111058
Uniprot IDs		O00292	A0A0B4J1R2 Q9H6R3
PDB IDs
Enriched GO Terms of Interacting Partners?		Kinesin Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Serotonin Uptake Propionate-CoA Ligase Activity Acetate-CoA Ligase Activity Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Ketone Body Biosynthetic Process Mitochondrial ATP Synthesis Coupled Electron Transport Generation Of Precursor Metabolites And Energy Cuprous Ion Binding Regulation Of Chaperone-mediated Autophagy Dopamine Uptake Involved In Synaptic Transmission Response To Iron(II) Ion Dopamine Biosynthetic Process Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Cellular Respiration Neuronal Cell Body Negative Regulation Of Oxidative Phosphorylation Signal Complex Assembly Nonassociative Learning Ketone Body Metabolic Process Medium-chain Fatty Acid-CoA Ligase Activity Regulation Of Membrane Potential Catecholamine Uptake Dopamine Uptake Regulation Of Acyl-CoA Biosynthetic Process Positive Regulation Of Inositol Phosphate Biosynthetic Process Supramolecular Fiber Mitochondrial Matrix JUN Kinase Binding SNARE Complex Assembly Cellular Response To Epinephrine Stimulus MAP-kinase Scaffold Activity Positive Regulation Of Receptor Recycling Regulation Of SNARE Complex Assembly Negative Regulation Of Microtubule Polymerization Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway ATP Synthesis Coupled Electron Transport	Transforming Growth Factor Beta Receptor Binding Anterior/posterior Axis Specification Platelet Alpha Granule Lumen BMP Signaling Pathway Axis Specification Growth Factor Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cytokine Activity Pattern Specification Process Extracellular Matrix
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