HAPLN3

Description		hyaluronan and proteoglycan link protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Synapse Perineuronal Net
	Molecular Function	Hyaluronic Acid Binding
	Biological Process	Skeletal System Development Cell Adhesion Central Nervous System Development
Pathways
Drugs		Hyaluronic acid
Diseases
GWAS		Appendicular lean mass ( 33097823) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Lung cancer in ever smokers ( 28604730) Multiple keratinocyte cancers ( 28081215) Waist circumference adjusted for body mass index ( 34021172)
Novel Interacting Genes		1 novel interacting genes: CRTC3
Interacting Genes
Entrez ID		145864
HPRD ID		13629
Ensembl ID		ENSG00000140511
Uniprot IDs		A8K7T8 H3BTH8 Q96S86
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway CAMP Response Element Binding Protein Binding Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Lipid Catabolic Process Protein Homotetramerization Regulation Of Lipid Catabolic Process Macrophage Activation Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Cellular Response To CAMP Energy Homeostasis Response To CAMP Protein Tetramerization Negative Regulation Of Lipid Metabolic Process Myeloid Leukocyte Activation Response To Purine-containing Compound Regulation Of G Protein-coupled Receptor Signaling Pathway
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