PLA2G2F and MICOS10-NBL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLA2G2F	MICOS10-NBL1
Description		phospholipase A2 group IIF	MICOS10-NBL1 readthrough
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Membrane	Extracellular Region Extracellular Space
	Molecular Function	Phospholipase A2 Activity Calcium Ion Binding Protein Binding Phospholipid Binding Hydrolase Activity Metal Ion Binding Calcium-dependent Phospholipase A2 Activity	Protein Binding Morphogen Activity BMP Binding Identical Protein Binding Receptor Ligand Activity
	Biological Process	Immune System Process Lipid Metabolic Process Phospholipid Metabolic Process Lipid Catabolic Process Arachidonate Metabolic Process Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Negative Regulation Of T Cell Proliferation Innate Immune Response Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Arachidonate Secretion	Signal Transduction Nervous System Development Neuron Differentiation Negative Regulation Of BMP Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Sequestering Of BMP In Extracellular Matrix Sequestering Of BMP From Receptor Via BMP Binding Positive Regulation Of Neuron Differentiation Determination Of Dorsal Identity Neuron Projection Morphogenesis Negative Regulation Of Monocyte Chemotaxis
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA
Drugs
Diseases
GWAS		Group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471)
Interacting Genes		3 interacting genes: MICOS10-NBL1 NBL1 VENTX	11 interacting genes: DPEP2NB HPCAL1 KRTAP11-1 LRIG1 MEOX2 MRPL12 NCALD PLA2G2F SLPI UBQLN1 UBQLN2
Entrez ID		64600	100532736
HPRD ID		07499
Ensembl ID		ENSG00000158786	ENSG00000158747
Uniprot IDs		Q9BZM2	P41271
PDB IDs			4X1J 4YU8
Enriched GO Terms of Interacting Partners?		Sequestering Of BMP In Extracellular Matrix Sequestering Of BMP From Receptor Via BMP Binding Determination Of Dorsal Identity Morphogen Activity Negative Regulation Of Monocyte Chemotaxis Sequestering Of Extracellular Ligand From Receptor Extracellular Negative Regulation Of Signal Transduction BMP Binding Negative Regulation Of Leukocyte Chemotaxis Regulation Of Monocyte Chemotaxis Negative Regulation Of Mononuclear Cell Migration Negative Regulation Of Chemotaxis Negative Regulation Of Leukocyte Migration Maintenance Of Protein Location Dorsal/ventral Pattern Formation Negative Regulation Of BMP Signaling Pathway Maintenance Of Location Positive Regulation Of Neuron Differentiation Regulation Of BMP Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Receptor Ligand Activity Regulation Of Mononuclear Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Neuron Differentiation Regulation Of Chemotaxis Regulation Of Leukocyte Migration Neuron Projection Morphogenesis Regionalization Cell Projection Morphogenesis Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Motility Neuron Differentiation Negative Regulation Of Locomotion Pattern Specification Process Cell Differentiation Negative Regulation Of Immune System Process Nervous System Development Cellular Developmental Process Positive Regulation Of Cell Differentiation Regulation Of Cell Migration Regulation Of Cell Motility System Development Regulation Of Locomotion Cell Projection Organization Positive Regulation Of Developmental Process Negative Regulation Of Signal Transduction Anatomical Structure Morphogenesis Extracellular Space	Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress
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